グルタミン酸ラセマーゼとは - わかりやすく解説 Weblio辞書

ウィキペディア

索引トップ用語の索引ランキングカテゴリー

グルタミン酸ラセマーゼ

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2013/03/02 12:03 UTC 版)

グルタミン酸ラセマーゼ(Glutamate racemase、MurI、EC 5.1.1.3)は、以下の化学反応を触媒する酵素である。

出典

^ ^a ^b ^c ^d ^e Kim KH, Bong YJ, Park JK, Shin KJ, Hwang KY, Kim EE (September 2007). “Structural basis for glutamate racemase inhibition”. J. Mol. Biol. 372 (2): 434-43. doi:10.1016/j.jmb.2007.05.003. PMID 17658548.
^ ^a ^b ^c ^d ^e ^f ^g ^h Sengupta S, Ghosh S, Nagaraja V (September 2008). “Moonlighting function of glutamate racemase from Mycobacterium tuberculosis: racemization and DNA gyrase inhibition are two independent activities of the enzyme”. Microbiology (Reading, Engl.) 154 (Pt 9): 2796-803. doi:10.1099/mic.0.2008/020933-0. PMID 18757813.
^ ^a ^b Reece RJ, Maxwell A (1991). “DNA gyrase: structure and function”. Crit. Rev. Biochem. Mol. Biol. 26 (3-4): 335-75. doi:10.3109/10409239109114072. PMID 1657531.
^ PDB 2OHV; Kim KH, Bong YJ, Park JK, Shin KJ, Hwang KY, Kim EE (September 2007). “Structural basis for glutamate racemase inhibition”. J. Mol. Biol. 372 (2): 434–43. doi:10.1016/j.jmb.2007.05.003. PMID 17658548.
^ ^a ^b Hwang KY, Cho CS, Kim SS, Sung HC, Yu YG, Cho Y (May 1999). “Structure and mechanism of glutamate racemase from Aquifex pyrophilus”. Nat. Struct. Biol. 6 (5): 422-6. doi:10.1038/8223. PMID 10331867.
^ ^a ^b ^c ^d ^e Ruzheinikov SN, Taal MA, Sedelnikova SE, Baker PJ, Rice DW (November 2005). “Substrate-induced conformational changes in Bacillus subtilis glutamate racemase and their implications for drug discovery”. Structure 13 (11): 1707-13. doi:10.1016/j.str.2005.07.024. PMID 16271894.
^ Schleifer KH, Kandler O (December 1972). “Peptidoglycan types of bacterial cell walls and their taxonomic implications”. Bacteriol Rev 36 (4): 407-77. PMC 408328. PMID 4568761.
^ ^a ^b Glavas S, Tanner ME (May 2001). “Active site residues of glutamate racemase”. Biochemistry 40 (21): 6199-204. doi:10.1021/bi002703z. PMID 11371180.
^ Lundqvist T, Fisher SL, Kern G, Folmer RH, Xue Y, Newton DT, Keating TA, Alm RA, de Jonge BL (June 2007). “Exploitation of structural and regulatory diversity in glutamate racemases”. Nature 447 (7146): 817-22. doi:10.1038/nature05689. PMID 17568739.
^ Sengupta S, Shah M, Nagaraja V (2006). “Glutamate racemase from Mycobacterium tuberculosis inhibits DNA gyrase by affecting its DNA-binding”. Nucleic Acids Res. 34 (19): 5567-76. doi:10.1093/nar/gkl704. PMC 1635304. PMID 17020913.
^ ^a ^b ^c ^d Sengupta S, Nagaraja V (February 2008). “Inhibition of DNA gyrase activity by Mycobacterium smegmatis MurI”. FEMS Microbiol. Lett. 279 (1): 40-7. doi:10.1111/j.1574-6968.2007.01005.x. PMID 18177305.
^ T. Selwood and E. K. Jaffe. (2011). “Dynamic dissociating homo-oligomers and the control of protein function.”. Arch. Biochem. Biophys. 519 (2): 131-43. doi:10.1016/j.abb.2011.11.020. PMC 3298769. PMID 22182754.