トレオース核酸
(threose nucleic acid から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/03/20 15:30 UTC 版)
トレオース核酸（Threose nucleic acid、TNA）は、天然のRNAに存在する5炭素のリボースが4炭素のトレオースに置き換えられた人工の核酸ポリマーである[1]。TNAはアルバート・エッシェンモーザーによって、RNAの化学的起源を探索する研究の一部として作成された[2]。TNAは相補的なDNAやRNAの配列と効率的に塩基対を形成することができるため、人工の遺伝的ポリマー（XNA）として重要なものとなった[1]。DNAやRNAとは異なり、TNAはヌクレアーゼによる分解に対して完全な耐性を持つため、治療や診断用途で有望な核酸アナログとなっている[3]。
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- ^ a b Schöning, K.; Scholz, P.; Guntha, S.; Wu, X.; Krishnamurthy, R.; Eschenmoser, A. (2000-11-17). “Chemical etiology of nucleic acid structure: the alpha-threofuranosyl-(3'-->2') oligonucleotide system”. Science (New York, N.Y.) 290 (5495): 1347–1351. doi:10.1126/science.290.5495.1347. ISSN 0036-8075. PMID 11082060.
- ^ Eschenmoser, A. (1999-06-25). “Chemical etiology of nucleic acid structure”. Science (New York, N.Y.) 284 (5423): 2118–2124. doi:10.1126/science.284.5423.2118. ISSN 0036-8075. PMID 10381870.
- ^ Culbertson, Michelle C.; Temburnikar, Kartik W.; Sau, Sujay P.; Liao, Jen-Yu; Bala, Saikat; Chaput, John C. (2016-05-15). “Evaluating TNA stability under simulated physiological conditions”. Bioorganic & Medicinal Chemistry Letters 26 (10): 2418–2421. doi:10.1016/j.bmcl.2016.03.118. ISSN 1464-3405. PMID 27080186.
- ^ Sau, Sujay P.; Fahmi, Nour Eddine; Liao, Jen-Yu; Bala, Saikat; Chaput, John C. (2016-03-18). “A Scalable Synthesis of α-L-Threose Nucleic Acid Monomers”. The Journal of Organic Chemistry 81 (6): 2302–2307. doi:10.1021/acs.joc.5b02768. ISSN 1520-6904. PMID 26895480.
- ^ Larsen, Andrew C.; Dunn, Matthew R.; Hatch, Andrew; Sau, Sujay P.; Youngbull, Cody; Chaput, John C. (2016-04-05). “A general strategy for expanding polymerase function by droplet microfluidics”. Nature Communications 7: 11235. doi:10.1038/ncomms11235. ISSN 2041-1723. PMC: 4822039. PMID 27044725.
- ^ Nikoomanzar, Ali; Vallejo, Derek; Chaput, John C. (2019-06-21). “Elucidating the Determinants of Polymerase Specificity by Microfluidic-Based Deep Mutational Scanning”. ACS synthetic biology 8 (6): 1421–1429. doi:10.1021/acssynbio.9b00104. ISSN 2161-5063. PMID 31081325.
- ^ Yu, Hanyang; Zhang, Su; Chaput, John C. (2012-01-10). “Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor”. Nature Chemistry 4 (3): 183–187. doi:10.1038/nchem.1241. ISSN 1755-4349. PMID 22354431.
- ^ Mei, Hui; Liao, Jen-Yu; Jimenez, Randi M.; Wang, Yajun; Bala, Saikat; McCloskey, Cailen; Switzer, Christopher; Chaput, John C. (2018-05-02). “Synthesis and Evolution of a Threose Nucleic Acid Aptamer Bearing 7-Deaza-7-Substituted Guanosine Residues”. Journal of the American Chemical Society 140 (17): 5706–5713. doi:10.1021/jacs.7b13031. ISSN 1520-5126. PMID 29667819.
- ^ Rangel, Alexandra E.; Chen, Zhe; Ayele, Tewoderos M.; Heemstra, Jennifer M. (2018-09-19). “In vitro selection of an XNA aptamer capable of small-molecule recognition”. Nucleic Acids Research 46 (16): 8057–8068. doi:10.1093/nar/gky667. ISSN 1362-4962. PMC: 6144807. PMID 30085205.
- ^ Pinheiro, Vitor B.; Taylor, Alexander I.; Cozens, Christopher; Abramov, Mikhail; Renders, Marleen; Zhang, Su; Chaput, John C.; Wengel, Jesper et al. (2012-04-20). “Synthetic genetic polymers capable of heredity and evolution”. Science (New York, N.Y.) 336 (6079): 341–344. doi:10.1126/science.1217622. ISSN 1095-9203. PMC: 3362463. PMID 22517858.
- ^ Chim, Nicholas; Shi, Changhua; Sau, Sujay P.; Nikoomanzar, Ali; Chaput, John C. (2017-11-27). “Structural basis for TNA synthesis by an engineered TNA polymerase”. Nature Communications 8 (1): 1810. doi:10.1038/s41467-017-02014-0. ISSN 2041-1723. PMC: 5703726. PMID 29180809.
- ^ Jackson, Lynnette N.; Chim, Nicholas; Shi, Changhua; Chaput, John C. (2019-07-26). “Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase”. Nucleic Acids Research 47 (13): 6973–6983. doi:10.1093/nar/gkz513. ISSN 1362-4962. PMC: 6649750. PMID 31170294.
- ^ Orgel, L. (2000-11-17). “Origin of life. A simpler nucleic acid”. Science (New York, N.Y.) 290 (5495): 1306–1307. doi:10.1126/science.290.5495.1306. ISSN 0036-8075. PMID 11185405.
- ^ Yu, Hanyang; Zhang, Su; Chaput, John C. (2012-01-10). “Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor”. Nature Chemistry 4 (3): 183–187. doi:10.1038/nchem.1241. ISSN 1755-4349. PMID 22354431.
- ^ Liu, Ling Sum; Leung, Hoi Man; Tam, Dick Yan; Lo, Tsz Wan; Wong, Sze Wing; Lo, Pik Kwan (2018-03-21). “α-l-Threose Nucleic Acids as Biocompatible Antisense Oligonucleotides for Suppressing Gene Expression in Living Cells”. ACS applied materials & interfaces 10 (11): 9736–9743. doi:10.1021/acsami.8b01180. ISSN 1944-8252. PMID 29473733.
[続きの解説]
「トレオース核酸」の続きの解説一覧
- 1 トレオース核酸とは
- 2 トレオース核酸の概要
- 3 関連文献
- threose nucleic acidのページへのリンク
