インテグリン結合キナーゼ
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/10/09 14:37 UTC 版)
インテグリン結合キナーゼまたはインテグリン連結キナーゼ（インテグリンけつごう/れんけつキナーゼ、英: integrin-linked kinase、略称: ILK）は、ヒトではILK遺伝子にコードされるタンパク質であり、インテグリンを介したシグナル伝達に関与している。ILK遺伝子の変異は、心筋症と関係している[5][6]。59 kDaのタンパク質であり、インテグリンβ1をベイトタンパク質とした酵母ツーハイブリッド法によって同定された[7]。ILKは、細胞遊走、増殖、接着など複数の細胞機能と関係していることが知られている。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000166333 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030890 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ Brodehl, Andreas; Rezazadeh, Saman; Williams, Tatjana; Munsie, Nicole M.; Liedtke, Daniel; Oh, Tracey; Ferrier, Raechel; Shen, Yaoqing et al. (2019-02-15). “Mutations in ILK, encoding integrin-linked kinase, are associated with arrhythmogenic cardiomyopathy”. Translational Research 208: 15–29. doi:10.1016/j.trsl.2019.02.004. ISSN 1878-1810. PMC 7412573. PMID 30802431.
- ^ Knöll, Ralph; Postel, Ruben; Wang, Jianming; Krätzner, Ralph; Hennecke, Gerrit; Vacaru, Andrei M.; Vakeel, Padmanabhan; Schubert, Cornelia et al. (2007-07-31). “Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells”. Circulation 116 (5): 515–525. doi:10.1161/CIRCULATIONAHA.107.689984. ISSN 1524-4539. PMID 17646580.
- ^ a b c “Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase”. Nature 379 (6560): 91–6. (1996). Bibcode: 1996Natur.379...91H. doi:10.1038/379091a0. PMID 8538749.
- ^ a b “Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling”. Trends in Cell Biology 9 (8): 319–23. (1999). doi:10.1016/s0962-8924(99)01612-8. PMID 10407411.
- ^ a b c d e f g “Integrin-linked kinase at a glance”. Journal of Cell Science 125 (Pt 8): 1839–43. (2012). doi:10.1242/jcs.093864. PMID 22637643.
- ^ a b c d e “Insights into the Structure, Function, and Ion-Mediated Signaling Pathways Transduced by Plant Integrin-Linked Kinases”. Frontiers in Plant Science 8: 376. (2017). doi:10.3389/fpls.2017.00376. PMC 5376563. PMID 28421082.
- ^ “Entrez Gene: ILK integrin-linked kinase”. 2021年8月29日閲覧。
- ^ “Integrin-linked kinase is an adaptor with essential functions during mouse development”. Nature 461 (7266): 1002–6. (October 2009). Bibcode: 2009Natur.461.1002L. doi:10.1038/nature08468. PMID 19829382.
- ^ “The pseudoactive site of ILK is essential for its binding to alpha-Parvin and localization to focal adhesions”. Molecular Cell 36 (5): 819–30. (December 2009). doi:10.1016/j.molcel.2009.11.028. PMC 2796127. PMID 20005845.
- ^ “ILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling”. Current Opinion in Cell Biology 24 (5): 607–13. (October 2012). doi:10.1016/j.ceb.2012.06.003. PMC 3467332. PMID 22763012.
- ^ “Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization”. The Journal of Cell Biology 180 (4): 681–9. (February 2008). doi:10.1083/jcb.200710074. PMC 2265580. PMID 18283114.
- ^ “Large-scale mapping of human protein-protein interactions by mass spectrometry”. Molecular Systems Biology 3: 89. (2007). doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- ^ “Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI”. The Journal of Biological Chemistry 277 (15): 12874–8. (April 2002). doi:10.1074/jbc.M200482200. PMID 11825911.
- ^ “Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase”. Proceedings of the National Academy of Sciences of the United States of America 95 (19): 11211–6. (September 1998). Bibcode: 1998PNAS...9511211D. doi:10.1073/pnas.95.19.11211. PMC 21621. PMID 9736715.
- ^ “Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343”. The Journal of Biological Chemistry 276 (29): 27462–9. (July 2001). doi:10.1074/jbc.M102940200. PMID 11313365.
- ^ “Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1”. The EMBO Journal 20 (9): 2160–70. (May 2001). doi:10.1093/emboj/20.9.2160. PMC 125446. PMID 11331582.
- ^ “The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells”. Molecular and Cellular Biology 19 (3): 2425–34. (March 1999). doi:10.1128/mcb.19.3.2425. PMC 84035. PMID 10022929.
- ^ “Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration”. The Journal of Biological Chemistry 277 (41): 38328–38. (October 2002). doi:10.1074/jbc.M205576200. PMID 12167643.
- ^ a b c d e f g h i Brauer, Elizabeth (June 2016). “The Raf-like Kinsase ILK1 and the High Affinity K+ Transporter HAK5 Are Required for Innate Immunity and Abiotic Stress Response”. Plant Physiology 171 (2): 1470–1484. doi:10.1104/pp.16.00035. PMC 4902592. PMID 27208244.
- ^ “Root K(+) acquisition in plants: the Arabidopsis thaliana model”. Plant & Cell Physiology 52 (9): 1603–12. (2011). doi:10.1093/pcp/pcr096. PMID 21771865.
- ^ a b “Regulation of potassium transport and signaling in plants”. Current Opinion in Plant Biology 39: 123–128. (October 2017). doi:10.1016/j.pbi.2017.06.006. PMID 28710919.
[続きの解説]
「インテグリン結合キナーゼ」の続きの解説一覧
- 1 インテグリン結合キナーゼとは
- 2 インテグリン結合キナーゼの概要
- 3 主な特徴
- 4 関連文献
- インテグリン結合キナーゼのページへのリンク
