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MDC1

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/04/15 15:16 UTC 版)

MDC1（mediator of DNA damage checkpoint 1）は、ヒトでは6番染色体（英語版）短腕（p）に位置するMDC1遺伝子にコードされる、2080アミノ酸からなるタンパク質である^[5]^[6]^[7]。MDC1はS期内チェックポイントとG₂/M期チェックポイントの調節因子であり、DNA損傷部位へ修復タンパク質をリクルートする。また、がん抑制タンパク質p53と結合し、細胞生存運命の決定にも関与する。このタンパク質はNFBD1（nuclear factor with BRCT domain 1）という別名でも知られる。

出典

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000224587、ENSG00000237095、ENSG00000137337、ENSG00000206481、ENSG00000234012、ENSG00000231135、ENSG00000228575、ENSG00000225589 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061607 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain”. DNA Cell Biol 19 (8): 475–485. (Sep 2000). doi:10.1089/10445490050128403. PMID 10975465.
^ ^a ^b “MDC1 is a mediator of the mammalian DNA damage checkpoint”. Nature 421 (6926): 961–966. (Feb 2003). Bibcode: 2003Natur.421..961S. doi:10.1038/nature01446. PMID 12607005.
^ “Entrez Gene: MDC1 mediator of DNA damage checkpoint 1”. 2023年4月15日閲覧。
^ “The DNA damage response: putting checkpoints in perspective”. Nature 408 (6811): 433–439. (Nov 2000). Bibcode: 2000Natur.408..433Z. doi:10.1038/35044005. PMID 11100718.
^ ^a ^b ^c ^d ^e ^f “MDC1: The art of keeping things in focus”. Chromosoma 119 (4): 337–349. (Aug 2010). doi:10.1007/s00412-010-0266-9. PMID 20224865.
^ ^a ^b “MDC1 regulates DNA-PK autophosphorylation in response to DNA damage”. J Biol Chem 279 (45): 46359–62. (Nov 2004). doi:10.1074/jbc.c400375200. PMID 15377652.
^ ^a ^b ^c ^d “NFBD1/MDC1 associates with p53 and regulates its function at the crossroad between cell survival and death in response to DNA damage.”. J Biol Chem 282 (31): 22993–3004. (Aug 2007). doi:10.1074/jbc.m611412200. PMID 17535811.
^ “MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways”. Nature 421 (6926): 957–61. (Feb 2003). Bibcode: 2003Natur.421..957L. doi:10.1038/nature01447. PMID 12607004.
^ ^a ^b “NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors”. FASEB J. 17 (13): 1842–8. (Oct 2003). doi:10.1096/fj.03-0310com. PMID 14519663.
^ “Serial interactome capture of the human cell nucleus”. Nature Communications 7: 11212. (2016-01-01). Bibcode: 2016NatCo...711212C. doi:10.1038/ncomms11212. PMC 4822031. PMID 27040163.
^ “Human Rad50/Mre11 is a flexible complex that can tether DNA ends”. Mol Cell 8 (5): 1129–1135. (Nov 2001). doi:10.1016/s1097-2765(01)00381-1. PMID 11741547.
^ “Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks”. J Cell Biol 173 (2): 195–206. (Apr 2006). doi:10.1083/jcb.200510130. PMC 2063811. PMID 16618811.
^ “MDC1 is required for the intra-S- phase DNA damage checkpoint”. Nature 421 (6926): 952–956. (Feb 2003). Bibcode: 2003Natur.421..952G. doi:10.1038/nature01445. PMID 12607003.
^ “Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX- dependent chromatin retention”. EMBO J 23 (13): 2674–2683. (Jul 2004). doi:10.1038/sj.emboj.7600269. PMC 449779. PMID 15201865.
^ “MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals”. Mol Cell 21 (2): 187–200. (Jan 2006). doi:10.1016/j.molcel.2005.11.025. PMID 16427009.
^ “The DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosome”. J Biol Chem 282 (44): 32053–32064. (Sep 2007). doi:10.1074/jbc.m705890200. PMID 17827148.
^ “Topoisomerase IIalpha controls the decatenation checkpoint”. Nat Cell Biol 11 (2): 204–210. (Feb 2009). doi:10.1038/ncb1828. PMC 2712943. PMID 19098900.
^ “MicroRNA-22 Suppresses DNA Repair and Promotes Genomic Instability through Targeting of MDC1”. Cancer Research 75 (7): 1298–1310. (Apr 2015). doi:10.1158/0008-5472.CAN-14-2783. PMID 25627978.
^ “Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis”. J Cell Biol 181 (5): 727–735. (Jun 2008). doi:10.1083/jcb.200801083. PMC 2396806. PMID 18504301.
^ “DNA damage response mediators MDC1 and 53BP1: constitu- tive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours”. Oncogene 26 (53): 7414–7422. (Jun 2007). doi:10.1038/sj.onc.1210553. PMID 17546051.
^ “Growth inhibition, morphology change, and cell cycle alterations in NFBD1-depleted human esophageal cancer cells”. Mol Cell Biochem 342 (1–2): 1–6. (Sep 2010). doi:10.1007/s11010-010-0460-3. PMID 20364298.
^ “NFBD1/MDC1 is a protein of oncogenic potential in human cervical cancer”. Mol Cell Biochem 359 (1–2): 333–46. (Jan 2010). doi:10.1007/s11010-011-1027-7. PMID 21853275.

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