RNF8
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/07/29 04:15 UTC 版)
RNF8（ring finger protein 8）は、ヒトではRNF8遺伝子にコードされる酵素である[5][6][7]。RNF8は免疫系の機能[8]とDNA修復の双方に活性を有する。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000112130 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090083 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
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- ^ “Isolation, tissue expression, and chromosomal assignment of a novel human gene which encodes a protein with RING finger motif”. Journal of Human Genetics 43 (4): 272–4. (Jan 1999). doi:10.1007/s100380050088. PMID 9852682.
- ^ a b “Entrez Gene: RNF8 ring finger protein 8”. 2022年5月28日閲覧。
- ^ “The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination”. Proc. Natl. Acad. Sci. U.S.A. 107 (2): 809–14. (2010). Bibcode: 2010PNAS..107..809R. doi:10.1073/pnas.0913790107. PMC 2818930. PMID 20080757.
- ^ a b c “The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination”. J. Biol. Chem. 287 (52): 43984–94. (2012). doi:10.1074/jbc.M112.421545. PMC 3527981. PMID 23115235.
- ^ a b c “Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response”. J. Cell Biol. 186 (6): 835–47. (2009). doi:10.1083/jcb.200902150. PMC 2753161. PMID 19797077.
- ^ “The E3 ligase RNF8 regulates KU80 removal and NHEJ repair”. Nat. Struct. Mol. Biol. 19 (2): 201–6. (2012). doi:10.1038/nsmb.2211. PMC 3888515. PMID 22266820.
- ^ “DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture”. Molecular Cancer Research 6 (4): 517–24. (April 2008). doi:10.1158/1541-7786.MCR-08-0020. PMID 18403632.
- ^ a b “Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer”. J. Exp. Med. 207 (5): 983–97. (2010). doi:10.1084/jem.20092437. PMC 2867283. PMID 20385750.
- ^ “Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis”. PLOS Genet. 9 (1): e1003259. (2013). doi:10.1371/journal.pgen.1003259. PMC 3561120. PMID 23382699.
- ^ a b “DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139”. J. Biol. Chem. 273 (10): 5858–68. (1998). doi:10.1074/jbc.273.10.5858. PMID 9488723.
- ^ “RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins”. Cell 131 (5): 887–900. (2007). doi:10.1016/j.cell.2007.09.040. PMID 18001824.
- ^ “MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks”. Cell 123 (7): 1213–26. (2005). doi:10.1016/j.cell.2005.09.038. PMID 16377563.
- ^ “Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage”. EMBO Rep. 9 (8): 795–801. (2008). doi:10.1038/embor.2008.103. PMC 2442910. PMID 18583988.
- ^ “A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure”. EMBO J. 31 (11): 2511–27. (2012). doi:10.1038/emboj.2012.104. PMC 3365417. PMID 22531782.
- ^ “DNA End Resection: Facts and Mechanisms”. Genomics Proteomics Bioinformatics 14 (3): 126–30. (2016). doi:10.1016/j.gpb.2016.05.002. PMC 4936662. PMID 27240470.
- ^ “Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks”. FEBS Lett. 591 (6): 842–853. (2017). doi:10.1002/1873-3468.12596. PMID 28194753.
- ^ “RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment”. J. Biol. Chem. 291 (18): 9396–410. (2016). doi:10.1074/jbc.M116.715698. PMC 4850281. PMID 26903517.
- ^ “A Ku bridge over broken DNA”. Structure 9 (10): 881–4. (2001). doi:10.1016/s0969-2126(01)00658-x. PMID 11591342.
- ^ “Non-homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair process”. BioEssays 39 (3): 1600209. (2017). doi:10.1002/bies.201600209. PMID 28133776.
- ^ a b “Neddylation promotes ubiquitylation and release of Ku from DNA-damage sites”. Cell Rep 11 (5): 704–14. (2015). doi:10.1016/j.celrep.2015.03.058. PMC 4431666. PMID 25921528.
- ^ “Ku80 removal from DNA through double strand break-induced ubiquitylation”. J. Cell Biol. 182 (3): 467–79. (2008). doi:10.1083/jcb.200802146. PMC 2500133. PMID 18678709.
- ^ “Insight in DNA Repair of UV-induced Pyrimidine Dimers by Chromatographic Methods”. Photochem. Photobiol. 93 (1): 207–215. (2017). doi:10.1111/php.12685. PMID 27935042.
- ^ “RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage”. J. Biol. Chem. 283 (20): 13549–55. (2008). doi:10.1074/jbc.M710197200. PMID 18337245.
- ^ “The RING finger protein, RNF8, interacts with retinoid X receptor alpha and enhances its transcription-stimulating activity”. The Journal of Biological Chemistry 279 (18): 18926–34. (Apr 2004). doi:10.1074/jbc.M309148200. PMID 14981089.
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