eIF4A
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/01/18 15:36 UTC 版)
eIF4A（eukaryotic initiation factor 4A）ファミリーは、3種類の密接に関連したタンパク質、eIF4A1、eIF4A2、eIF4A3からなる。しかしながらeIF4A3は他の2つとは異なる機能を持ち、一般的に「eIF4A」という場合にはeIF4A1ならびにeIF4A2を指すことが多い。eIF4Aはリボソーム40SサブユニットがmRNAに結合するために必要であり、また二本鎖RNAを巻き戻すヘリカーゼとしても機能する[1][2]。
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- ^ “Crystal structure of the yeast eIF4A-eIF4G complex: an RNA-helicase controlled by protein-protein interactions”. Proceedings of the National Academy of Sciences of the United States of America 105 (28): 9564–9. (Jul 2008). Bibcode: 2008PNAS..105.9564S. doi:10.1073/pnas.0800418105. PMC 2474498. PMID 18606994.
- ^ “eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation”. Annual Review of Biochemistry 68 (1): 913–63. (June 1999). doi:10.1146/annurev.biochem.68.1.913. PMID 10872469.
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- ^ “The activity of ribosomes of sea urchin eggs in response to fertilization”. Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis 179 (2): 381–8. (Apr 1969). doi:10.1016/0005-2787(69)90046-X. PMID 5814313.
- ^ “Age-dependent decrease in the activity of protein-synthesis initiation factors in rat brain”. Mechanisms of Ageing and Development 21 (2): 183–91. (Feb 1983). doi:10.1016/0047-6374(83)90073-8. PMID 6865504.
- ^ “Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo”. The Journal of Biological Chemistry 276 (31): 29111–5. (Aug 2001). doi:10.1074/jbc.C100284200. PMID 11408474.
- ^ “Genetic regulatory mechanisms in the synthesis of proteins”. Journal of Molecular Biology 3 (3): 318–56. (Jun 1961). doi:10.1016/S0022-2836(61)80072-7. PMID 13718526.
- ^ Hershey JW Merrick WC (2000). “Pathway and mechanism of initiation of protein synthesis”. Translational control of gene expression. Plainview, N.Y: Cold Spring Harbor Laboratory Press. pp. 33–88. ISBN 978-0-87969-568-2
- ^ “Structure of the hepatitis C virus RNA helicase domain”. Nature Structural Biology 4 (6): 463–7. (Jun 1997). doi:10.1038/nsb0697-463. PMID 9187654.
- ^ “Interaction between the NH2-terminal domain of eIF4A and the central domain of eIF4G modulates RNA-stimulated ATPase activity”. The Journal of Biological Chemistry 280 (3): 1872–81. (Jan 2005). doi:10.1074/jbc.M406168200. PMID 15528191.
- ^ “Wheat germ translation initiation factor eIF4B affects eIF4A and eIFiso4F helicase activity by increasing the ATP binding affinity of eIF4A”. Biochemistry 39 (19): 5758–65. (May 2000). doi:10.1021/bi992322p. PMID 10801326.
- ^ “Nucleotide sequence of human cDNA encoding eukaryotic initiation factor 4AI”. Nucleic Acids Research 21 (8): 2012. (Apr 1993). doi:10.1093/nar/21.8.2012. PMC 309447. PMID 8493113.
- ^ “The linked human elongation initiation factor 4A1 (EIF4A1) and CD68 genes map to chromosome 17p13”. Genomics 53 (2): 248–50. (Oct 1998). doi:10.1006/geno.1998.5515. PMID 9790779.
- ^ “Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2”. Cytogenetics and Cell Genetics 71 (4): 385–8. (1995). doi:10.1159/000134145. PMID 8521730.
- ^ “A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A”. Biochemical and Biophysical Research Communications 267 (1): 339–44. (Jan 2000). doi:10.1006/bbrc.1999.1973. PMID 10623621.
- ^ “eIF4A3 is a novel component of the exon junction complex”. RNA 10 (2): 200–9. (Feb 2004). doi:10.1261/rna.5230104. PMC 1370532. PMID 14730019.
- ^ “Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A”. The EMBO Journal 11 (7): 2643–54. (Jul 1992). doi:10.1002/j.1460-2075.1992.tb05330.x. PMC 556740. PMID 1378397.
- ^ “Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase”. Proceedings of the National Academy of Sciences of the United States of America 97 (24): 13080–5. (Nov 2000). Bibcode: 2000PNAS...9713080C. doi:10.1073/pnas.97.24.13080. PMC 27181. PMID 11087862.
- ^ “Translational control by a small RNA: dendritic BC1 RNA targets the eukaryotic initiation factor 4A helicase mechanism”. Molecular and Cellular Biology 28 (9): 3008–19. (May 2008). doi:10.1128/MCB.01800-07. PMC 2293081. PMID 18316401.
- ^ “The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A”. The Journal of Biological Chemistry 268 (8): 5566–73. (Mar 1993). doi:10.1016/S0021-9258(18)53358-5. PMID 8449919.
- ^ “Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation”. Proceedings of the National Academy of Sciences of the United States of America 102 (30): 10460–5. (Jul 2005). Bibcode: 2005PNAS..10210460B. doi:10.1073/pnas.0504249102. PMC 1176247. PMID 16030146.
[続きの解説]
「eIF4A」の続きの解説一覧
- 1 eIF4Aとは
- 2 eIF4Aの概要
- 3 遺伝子
- 4 関連項目
- EIF4Aのページへのリンク
