c-Fosとは - わかりやすく解説 Weblio辞書

c-Fos

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/01/01 08:08 UTC 版)

c-Fosは、レトロウイルスのがん遺伝子v-fosのホモログであるがん原遺伝子（ヒトではFOS）にコードされるタンパク質である^[5]。c-Fosはラット線維芽細胞において、FBJ MSV（Finkel–Biskis–Jinkins murine osteogenic sarcoma virus）と呼ばれるウイルスの形質転換遺伝子との類似性から発見された^[6]。c-FosはFosファミリーの転写因子であり、Fosファミリーには他にFosB（英語版）、Fra-1（英語版）、Fra-2（英語版）が含まれる^[7]。c-Fosはc-Jun（英語版）とヘテロ二量体を形成してAP-1複合体となり、標的遺伝子のプロモーターやエンハンサー領域のAP-1特異的部位のDNAに結合することで、細胞外のシグナルを遺伝子発現の変化へと変換する^[8]。c-Fosは多くの細胞機能で重要な役割を果たしており、さまざまながんで過剰発現していることが知られている。

出典

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170345 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021250 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
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