SNAP-25とは - わかりやすく解説 Weblio辞書

SNAP25

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/04/30 17:57 UTC 版)

SNAP25（Synaptosomal-associated protein, 25kDa）は、ヒトではSNAP25遺伝子にコードされるt-SNAREタンパク質である^[5]。SNAP25はトランスSNARE複合体の構成要素であり、シナプス小胞と細胞膜との膜融合の特異性を担うとともに、緊密な複合体を形成することで両者の融合を実行する^[6]。

出典

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132639 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027273 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “Radiation hybrid mapping of SNAP, PCSK2, and THBD (human chromosome 20p)”. Mamm. Genome 7 (5): 400–1. (May 1996). doi:10.1007/s003359900120. PMID 8661740.
^ “Snares and Munc18 in synaptic vesicle fusion”. Nat Rev Neurosci 3 (8): 641–653. (2002). doi:10.1038/nrn898. PMID 12154365.
^ Georgiev, Danko D; James F . Glazebrook (2007). “Subneuronal processing of information by solitary waves and stochastic processes”. In Lyshevski, Sergey Edward. Nano and Molecular Electronics Handbook. Nano and Microengineering Series. CRC Press. pp. 17–1–17–41. doi:10.1201/9781420008142.ch17. ISBN 978-0-8493-8528-5
^ ^a ^b “SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils”. J. Biol. Chem. 269 (44): 27427–32. (1994). PMID 7961655.
^ “Specificity and regulation of a synaptic vesicle docking complex”. Neuron 13 (2): 353–61. (1994). doi:10.1016/0896-6273(94)90352-2. PMID 8060616.
^ “Protein-protein interactions contributing to the specificity of intracellular vesicular trafficking”. Science 263 (5150): 1146–9. (1994). Bibcode: 1994Sci...263.1146C. doi:10.1126/science.8108733. PMID 8108733.
^ “SNAP-25”. Int. J. Biochem. Cell Biol. 30 (10): 1069–73. (October 1998). doi:10.1016/S1357-2725(98)00079-X. PMID 9785471.
^ Chapman, Edwin R. (2002-07). “Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?”. Nature Reviews. Molecular Cell Biology 3 (7): 498–508. doi:10.1038/nrm855. ISSN 1471-0072. PMID 12094216.
^ “SNAP-25 modulation of calcium dynamics underlies differences in GABAergic and glutamatergic responsiveness to depolarization”. Neuron 41 (4): 599–610. (February 2004). doi:10.1016/S0896-6273(04)00077-7. PMID 14980208.
^ “Alternative splicing of SNAP-25 regulates secretion through nonconservative substitutions in the SNARE domain”. Mol. Biol. Cell 16 (12): 5675–85. (December 2005). doi:10.1091/mbc.E05-07-0595. PMC 1289412. PMID 16195346.
^ ^a ^b Bark, Christina (February 1995). “Differential expression of SNAP-25 protein isoforms during divergent vesicle fusion events of neural development”. Proceedings of the National Academy of Sciences 92 (5): 1510–1514. Bibcode: 1995PNAS...92.1510B. doi:10.1073/pnas.92.5.1510. PMC 42549. PMID 7878010.
^ “Synaptosomal-associated protein 25 (SNAP-25) and attention deficit hyperactivity disorder (ADHD): evidence of linkage and association in the Irish population”. Mol. Psychiatry 7 (8): 913–7. (2002). doi:10.1038/sj.mp.4001092. hdl:2262/36350. PMID 12232787.
^ “Association study of a SNAP-25 microsatellite and attention deficit hyperactivity disorder”. Am. J. Med. Genet. 114 (3): 269–71. (April 2002). doi:10.1002/ajmg.10253. PMID 11920846.
^ “Genome-wide association scan for five major dimensions of personality”. Mol. Psychiatry 15 (6): 647–56. (October 2008). doi:10.1038/mp.2008.113. PMC 2874623. PMID 18957941.
^ “Botulinum toxin type A and other botulinum toxin serotypes: a comparative review of biochemical and pharmacological actions”. Eur. J. Neurol. 8 Suppl 5: 21–9. (November 2001). doi:10.1046/j.1468-1331.2001.00035.x. PMID 11851731.
^ ^a ^b ^c “Three-dimensional structure of the complexin/SNARE complex”. Neuron 33 (3): 397–409. (January 2002). doi:10.1016/s0896-6273(02)00583-4. PMID 11832227.
^ “Action of complexin on SNARE complex”. J. Biol. Chem. 277 (44): 41652–6. (November 2002). doi:10.1074/jbc.M205044200. PMID 12200427.
^ “EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis?”. J. Biol. Chem. 274 (26): 18446–54. (June 1999). doi:10.1074/jbc.274.26.18446. PMID 10373452.
^ “The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23”. Biochemistry 41 (50): 14906–15. (Dec 2002). doi:10.1021/bi026417u. PMID 12475239.
^ ^a ^b “Snapin: a SNARE-associated protein implicated in synaptic transmission”. Nat. Neurosci. 2 (2): 119–24. (February 1999). doi:10.1038/5673. PMID 10195194.
^ ^a ^b “A human protein-protein interaction network: a resource for annotating the proteome”. Cell 122 (6): 957–68. (September 2005). doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
^ “Towards a proteome-scale map of the human protein-protein interaction network”. Nature 437 (7062): 1173–8. (October 2005). Bibcode: 2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
^ ^a ^b ^c ^d “A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic”. J. Biol. Chem. 270 (22): 13022–8. (June 1995). doi:10.1074/jbc.270.22.13022. PMID 7768895.
^ ^a ^b ^c ^d “Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues”. J. Biol. Chem. 271 (23): 13300–3. (June 1996). doi:10.1074/jbc.271.23.13300. PMID 8663154.
^ ^a ^b ^c “Three novel proteins of the syntaxin/SNAP-25 family”. J. Biol. Chem. 273 (51): 34171–9. (Dec 1998). doi:10.1074/jbc.273.51.34171. PMID 9852078.
^ “A conformational switch in syntaxin during exocytosis: role of munc18”. EMBO J. 18 (16): 4372–82. (August 1999). doi:10.1093/emboj/18.16.4372. PMC 1171512. PMID 10449403.
^ “Complexins: cytosolic proteins that regulate SNAP receptor function”. Cell 83 (1): 111–9. (October 1995). doi:10.1016/0092-8674(95)90239-2. PMID 7553862.
^ “Membrane localization and biological activity of SNAP-25 cysteine mutants in insulin-secreting cells”. J. Cell Sci. 113 (18): 3197–205. (September 2000). PMID 10954418.
^ ^a ^b ^c “Spring, a novel RING finger protein that regulates synaptic vesicle exocytosis”. J. Biol. Chem. 276 (44): 40824–33. (November 2001). doi:10.1074/jbc.M106141200. PMID 11524423.
^ “SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils”. J. Biol. Chem. 269 (44): 27427–32. (November 1994). PMID 7961655.
^ “Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion”. Blood 93 (8): 2617–26. (April 1999). doi:10.1182/blood.V93.8.2617. PMID 10194441.
^ “The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes”. J. Biol. Chem. 275 (9): 6328–36. (March 2000). doi:10.1074/jbc.275.9.6328. PMID 10692432.
^ “Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis”. Neuron 34 (4): 599–611. (May 2002). doi:10.1016/s0896-6273(02)00671-2. PMID 12062043.
^ “Effect of mutations in vesicle-associated membrane protein (VAMP) on the assembly of multimeric protein complexes”. J. Neurosci. 17 (5): 1596–603. (March 1997). doi:10.1523/JNEUROSCI.17-05-01596.1997. PMC 6573372. PMID 9030619.

「SNAP25」の続きの解説一覧

SNAP-25のページへのリンク

SNAP-25とは？わかりやすく解説

SNAP25

「SNAP-25」の関連用語

SNAP-25とは？ わかりやすく解説

SNAP25

急上昇のことば

「SNAP-25」の関連用語

SNAP-25とは？わかりやすく解説