インターロイキン-1β
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/03/21 20:55 UTC 版)
インターロイキン-1β（英: interleukin 1 beta、略称: IL-1β）はヒトではIL1B遺伝子にコードされるサイトカインで、leukocytic pyrogen、leukocytic endogenous mediator、mononuclear cell factor、lymphocyte activating factorなどの名称でも知られていた[5][6][7][8]。インターロイキン-1（IL-1）には2つの遺伝子が存在し、それぞれIL-1αとIL-1βをコードしている。IL-1β前駆体は細胞質のカスパーゼ1によって切断され、成熟したIL-1βが形成される。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000125538 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027398 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
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- ^ Rosenwasser, L. J.; Dinarello, C. A.; Rosenthal, A. S. (1979-09-19). “Adherent cell function in murine T-lymphocyte antigen recognition. IV. Enhancement of murine T-cell antigen recognition by human leukocytic pyrogen”. The Journal of Experimental Medicine 150 (3): 709–714. doi:10.1084/jem.150.3.709. ISSN 0022-1007. PMC 2185642. PMID 314491.
- ^ “Entrez Gene: IL1B interleukin 1, beta”. 2020年5月2日閲覧。
- ^ Sutton, Caroline E.; Lalor, Stephen J.; Sweeney, Cheryl M.; Brereton, Corinna F.; Lavelle, Ed C.; Mills, Kingston H. G. (2009-08-21). “Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity”. Immunity 31 (2): 331–341. doi:10.1016/j.immuni.2009.08.001. ISSN 1097-4180. PMID 19682929.
- ^ “NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases”. Redox Biology 4: 296–307. (April 2015). doi:10.1016/j.redox.2015.01.008. PMC 4315937. PMID 25625584.
- ^ “Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*)”. Annual Review of Immunology 27: 621–68. (2009). doi:10.1146/annurev.immunol.25.022106.141627. PMC 2996236. PMID 19302049.
- ^ “Dietary modulation of the microbiome affects autoinflammatory disease”. Nature 516 (7530): 246–9. (December 2014). Bibcode: 2014Natur.516..246L. doi:10.1038/nature13788. PMC 4268032. PMID 25274309.
- ^ “New Insights into the Role of IL-1β in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis”. Journal of Immunology 198 (12): 4553–4560. (June 2017). doi:10.4049/jimmunol.1700263. PMC 5509030. PMID 28583987.
- ^ “Role of the NLRP3 inflammasome in cancer”. Molecular Cancer 17 (1): 158. (November 2018). doi:10.1186/s12943-018-0900-3. PMC 6240225. PMID 30447690.
- ^ Milosevic, Vladan; Kopecka, Joanna; Salaroglio, Iris C.; Libener, Roberta; Napoli, Francesca; Izzo, Stefania; Orecchia, Sara; Ananthanarayanan, Preeta et al. (2020-01). “Wnt/IL‐1β/IL‐8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5” (英語). International Journal of Cancer 146 (1): 192–207. doi:10.1002/ijc.32419. ISSN 0020-7136.
- ^ Rébé, Cédric; Ghiringhelli, François (2020-07). “Interleukin-1β and Cancer” (英語). Cancers 12 (7): 1791. doi:10.3390/cancers12071791. ISSN 2072-6694. PMC PMC7408158. PMID 32635472.
- ^ “Distinct CD40L receptors mediate inflammasome activation and secretion of IL-1β and MCP-1 in cultured human retinal pigment epithelial cells”. Experimental Eye Research 170: 29–39. (May 2018). doi:10.1016/j.exer.2018.02.014. PMC 5924621. PMID 29454857.
- ^ “NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration”. Investigative Ophthalmology & Visual Science 54 (1): 110–20. (January 2013). doi:10.1167/iovs.12-10655. PMC 3544415. PMID 23221073.
- ^ “IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases”. Frontiers in Immunology 10: 1618. (2019-07-16). doi:10.3389/fimmu.2019.01618. PMC 6646526. PMID 31379825.
[続きの解説]
「インターロイキン-1β」の続きの解説一覧
- 1 インターロイキン-1βとは
- 2 インターロイキン-1βの概要
- 3 機能
- 4 性質
- 5 関連文献
- 6 関連項目
- インターロイキン-1βのページへのリンク
