AMP活性化プロテインキナーゼ
(AMPK から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/11/20 07:07 UTC 版)
AMP活性化プロテインキナーゼ（AMPかっせいかプロテインキナーゼ、英: 5' adenosine monophosphate-activated protein kinase、略称: AMPK）は、細胞のエネルギー状態の恒常性に関係する酵素（EC 2.7.11.31）で、細胞のエネルギーが低下しているときにグルコースと脂肪酸の取り込みと酸化を活性化する。高度に保存されたタンパク質ファミリーに属し、酵母のオルソログはSNF1、植物ではSnRK1と呼ばれる。AMPKは3つのタンパク質（サブユニット）によって機能的な酵素が構成されており、酵母からヒトまで保存されている。AMPKは、肝臓、脳、骨格筋など多数の組織で発現している。AMPとADPの結合に伴うAMPKの活性化によって、肝臓での脂肪酸の酸化の促進、ケトン生成、骨格筋での脂肪酸の酸化とグルコースの取り込みの促進、コレステロール合成の阻害、脂質生成、脂肪細胞での脂肪分解の阻害、膵臓のβ細胞でのインスリン分泌の調節が行われる[1]。
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[続きの解説]
「AMP活性化プロテインキナーゼ」の続きの解説一覧
- 1 AMP活性化プロテインキナーゼとは
- 2 AMP活性化プロテインキナーゼの概要
- 3 機能
- 4 臨床的意義
- 5 関連項目
- AMP活性化プロテインキナーゼのページへのリンク
