プソラレン
ソラレン
ソラレン
(psoralen から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/02/10 10:12 UTC 版)
ソラレン(Psoralen)は、直線型フラノクマリンとして知られる天然に存在する有機化合物の母核構造である。構造的には、クマリンにフラン環が融合しており、ウンベリフェロンの誘導体と考えることもできる。オランダビユ(Psoralea corylifolia)の種子に含まれる他、イチジクの葉、セロリ、パセリ、サンショウ、全ての柑橘類にも含まれる。乾癬、皮膚炎、尋常性白斑、皮膚T細胞性リンパ腫等の治療のためPUVA療法（ソラレンとUVAの併用）に広く用いられる。多くのフラノクマリンは魚類にとって猛毒で、インドネシアでは小川に投じて魚を捕まえるのに用いられる。
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- ^ https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm427111.htm
- ^ https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm427500.htm
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- ^ Wenle Xia; David Gooden; Leihua Liu; Sumin Zhao; Erik J. Soderblom; Eric J. Toone; Wayne F. Beyer Jr; Harold Walder et al. (February 14, 2014). Cheng, Jin. ed. “Photo-Activated Psoralen Binds the ErbB2 Catalytic Kinase Domain, Blocking ErbB2 Signaling and Triggering Tumor Cell Apoptosis”. PLoS ONE 9 (2): e88983. doi:10.1371/journal.pone.0088983. PMC 3925176. PMID 24551203.
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- ^ “Repair of psoralen-treated DNA by genetic recombination in human cells infected with herpes simplex virus”. Cancer Res. 41 (12 Pt 1): 5033-8. (1981). PMID 6272987.
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[続きの解説]
- psoralenのページへのリンク
