プロゲステロン受容体
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/12/11 15:05 UTC 版)
プロゲステロン受容体（Progesterone receptor；PR）は、NR3C3（核内受容体サブファミリー3、グループC、メンバー3）とも呼ばれる、細胞内に存在するタンパク質である。ステロイドホルモンであるプロゲステロンによって活性化される。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000082175 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031870 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA”. Biochemical and Biophysical Research Communications 143 (2): 740–8. (March 1987). doi:10.1016/0006-291X(87)91416-1. PMID 3551956.
- ^ “The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2”. Proceedings of the National Academy of Sciences of the United States of America 84 (9): 2877–81. (May 1987). Bibcode: 1987PNAS...84.2877L. doi:10.1073/pnas.84.9.2877. PMC 304763. PMID 3472240.
- ^ “Ensembl genome browser 54: H.sapiens - Gene summary - Gene: PGR (ENSG00000082175)”. may2009.archive.ensembl.org. 2022年1月5日閲覧。
- ^ “Progesterone receptors: various forms and functions in reproductive tissues”. Frontiers in Bioscience 10 (1–3): 2118–30. (2005). doi:10.2741/1685. PMID 15970482.
- ^ Kase, Nathan G.; Speroff, Leon; Glass, Robert L. (1999). Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 978-0-683-30379-7
- ^ Fritz, Marc A.; Speroff, Leon (2005). Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 978-0-7817-4795-0
- ^ Falcone, Tommaso; Hurd, William W. (22 May 2013). Clinical Reproductive Medicine and Surgery: A Practical Guide. Springer Science & Business Media. pp. 39–. ISBN 978-1-4614-6837-0
- ^ “Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B”. The EMBO Journal 9 (5): 1603–14. (May 1990). doi:10.1002/j.1460-2075.1990.tb08280.x. PMC 551856. PMID 2328727.
- ^ “Genetic variation in the progesterone receptor gene and ovarian cancer risk”. American Journal of Epidemiology 161 (5): 442–51. (March 2005). doi:10.1093/aje/kwi064. PMC 1380205. PMID 15718480.
- ^ “A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk”. Proceedings of the National Academy of Sciences of the United States of America 99 (19): 12263–8. (September 2002). Bibcode: 2002PNAS...9912263D. doi:10.1073/pnas.192172299. PMC 129433. PMID 12218173.
- ^ “No association between the progesterone receptor gene +331G/A polymorphism and breast cancer”. Cancer Epidemiology, Biomarkers & Prevention 13 (6): 1084–5. (June 2004). PMID 15184270.
- ^ “No association between progesterone receptor gene +331G/A polymorphism and endometrial cancer”. Cancer Epidemiology, Biomarkers & Prevention 15 (7): 1415–6. (July 2006). doi:10.1158/1055-9965.EPI-06-0215. PMID 16835347.
- ^ Rockwell, L. C.; Rowe, E. J.; Arnson, K.; Jackson, F.; Froment, A.; Ndumbe, P.; Seck, B.; Jackson, R. et al. (2012). “Worldwide distribution of allelic variation at the progesterone receptor locus and the incidence of female reproductive cancers”. American Journal of Human Biology 24 (1): 42–51. doi:10.1002/ajhb.21233. PMID 22121098.
- ^ “Mammary gland development”. Wiley Interdisciplinary Reviews. Developmental Biology 1 (4): 533–57. (2012). doi:10.1002/wdev.35. PMC 3404495. PMID 22844349.
- ^ “Minireview: Progesterone Regulation of Proliferation in the Normal Human Breast and in Breast Cancer: A Tale of Two Scenarios?”. Molecular Endocrinology 29 (9): 1230–42. (September 2015). doi:10.1210/me.2015-1152. PMC 5414684. PMID 26266959.
- ^ “Amphiregulin mediates progesterone-induced mammary ductal development during puberty”. Breast Cancer Research 15 (3): R44. (May 2013). doi:10.1186/bcr3431. PMC 3738150. PMID 23705924.
- ^ a b c “Progesterone Receptor Expression in the Developing Mesocortical Dopamine Pathway: Importance for Complex Cognitive Behavior in Adulthood”. Neuroendocrinology 103 (3–4): 207–22. (2016). doi:10.1159/000434725. PMC 4675705. PMID 26065828.
- ^ a b “Exposure to the Synthetic Progestin, 17α-Hydroxyprogesterone Caproate During Development Impairs Cognitive Flexibility in Adulthood”. Endocrinology 157 (1): 77–82. (January 2016). doi:10.1210/en.2015-1775. PMC 4701880. PMID 26556535.
- ^ a b “Tracking progesterone receptor-mediated actions in breast cancer”. Pharmacology & Therapeutics 142 (1): 114–25. (April 2014). doi:10.1016/j.pharmthera.2013.11.010. PMC 3943696. PMID 24291072.
- ^ “Selective interactions of Kruppel-like factor 9/basic transcription element-binding protein with progesterone receptor isoforms A and B determine transcriptional activity of progesterone-responsive genes in endometrial epithelial cells”. The Journal of Biological Chemistry 278 (24): 21474–82. (June 2003). doi:10.1074/jbc.M212098200. PMID 12672823.
- ^ “The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding”. Molecular and Cellular Biology 20 (9): 3102–15. (May 2000). doi:10.1128/MCB.20.9.3102-3115.2000. PMC 85605. PMID 10757795.
- ^ “The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily”. Molecular and Cellular Biology 19 (2): 1182–9. (February 1999). doi:10.1128/mcb.19.2.1182. PMC 116047. PMID 9891052.
[続きの解説]
「プロゲステロン受容体」の続きの解説一覧
- 1 プロゲステロン受容体とは
- 2 プロゲステロン受容体の概要
- 3 機序
- 4 動物研究
- 5 リガンド
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