トロポミオシン受容体キナーゼC
(Tropomyosin receptor kinase C から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/08/30 04:22 UTC 版)
トロポミオシン受容体キナーゼC（トロポミオシンじゅようたいキナーゼC、英: tropomyosin receptor kinase C、略称: TrkC）[5]またはNTRK3（neurotrophic receptor tyrosine kinase 3）は、ヒトではNTRK3遺伝子にコードされるタンパク質である[6]。TrkCは神経栄養因子NT-3（ニューロトロフィン3）に対する高親和性の酵素共役型受容体であり、神経の分化や生存など、この神経栄養因子の複数の効果を媒介する。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000140538 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059146 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Chapter 8: Atypical neurotransmitters”. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York: McGraw-Hill Medical. (2009). ISBN 978-0-07-148127-4. "Another common feature of neurotrophins is that they produce their physiologic effects by means of the tropomyosin receptor kinase (Trk) receptor family (also known as the tyrosine receptor kinase family). ... Try receptors. All neurotrophins bind to a class of highly homologous receptor tyrosine kinases known as Trk receptors, of which three types are known: TrkA, TrkB, and TrkC. These transmembrane receptors are glycoproteins whose molecular masses range from 140 to 145 kDa. Each type of Trk receptor tends to bind specific neurotrophins: TrkA is the receptor for NGF, TrkB the receptor for BDNF and NT-4, and TrkC the receptor for NT-3.However, some overlap in the specificity of these receptors has been noted."
- ^ “Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant”. Genomics 22 (2): 267–72. (July 1994). doi:10.1006/geno.1994.1383. PMID 7806211.
- ^ Tsoulfas, P. (2018). “Signaling by NTRK3 (TRKC)”. Reactome - A Curated Knowledgebase of Biological Pathways 65. doi:10.3180/R-HSA-9034015.1.
- ^ “Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex”. Neuron 69 (2): 287–303. (January 2011). doi:10.1016/j.neuron.2010.12.024. PMC 3056349. PMID 21262467.
- ^ “TrkC isoforms with inserts in the kinase domain show impaired signaling responses”. The Journal of Biological Chemistry 271 (10): 5691–7. (March 1996). doi:10.1074/jbc.271.10.5691. PMID 8621434.
- ^ “Emerging roles of the neurotrophin receptor TrkC in synapse organization”. Neuroscience Research 116 (2017): 10–17. (March 2017). doi:10.1016/j.neures.2016.09.009. PMID 27697534.
- ^ “Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children”. The New England Journal of Medicine 378 (8): 731–739. (February 2018). doi:10.1056/NEJMoa1714448. PMC 5857389. PMID 29466156.
- ^ “Origin and evolution of the Trk family of neurotrophic receptors”. Molecular and Cellular Neurosciences 31 (2): 179–92. (February 2006). doi:10.1016/j.mcn.2005.09.007. PMID 16253518.
- ^ “Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosis”. The Journal of Clinical Investigation 120 (3): 850–8. (March 2010). doi:10.1172/jci41013. PMC 2827960. PMID 20160348.
- ^ “Neurotrophic factors and their receptors”. Current Opinion in Cell Biology 7 (2): 148–55. (April 1995). doi:10.1016/0955-0674(95)80022-0. PMID 7612265.
- ^ “Roles of TrkC Signaling in the Regulation of Tumorigenicity and Metastasis of Cancer”. Cancers 12 (1): 147. (January 2020). doi:10.3390/cancers12010147. PMC 7016819. PMID 31936239..
- ^ “Neuroprotection: Pro-survival and Anti-neurotoxic Mechanisms as Therapeutic Strategies in Neurodegeneration”. Frontiers in Cellular Neuroscience 13 (231): 231. (31 January 2019). doi:10.3389/fncel.2019.00231. PMC 6563757. PMID 31244606.
- ^ “Tropomyosin Receptor Kinase C Targeted Delivery of a Peptidomimetic Ligand-Photosensitizer Conjugate Induces Antitumor Immune Responses Following Photodynamic Therapy”. Scientific Reports 6 (37209): 37209. (November 2016). doi:10.1038/srep37209. PMC 5112560. PMID 27853305.
- ^ “Oncogenes in solid human tumours”. Nature 300 (5892): 539–42. (December 1982). Bibcode: 1982Natur.300..539P. doi:10.1038/300539a0. PMID 7144906.
- ^ “An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101”. Cancer Discovery 5 (10): 1049–57. (October 2015). doi:10.1158/2159-8290.CD-15-0443. PMC 4635026. PMID 26216294.
- ^ “TrkC plays an essential role in breast tumor growth and metastasis”. Carcinogenesis 31 (11): 1939–47. (November 2010). doi:10.1093/carcin/bgq180. PMID 20802235.
- ^ “Trk receptor expression and inhibition in neuroblastomas”. Clinical Cancer Research 15 (10): 3244–50. (May 2009). doi:10.1158/1078-0432.ccr-08-1815. PMC 4238907. PMID 19417027.
- ^ “β-Phenethyl isothiocyanate induces death receptor 5 to induce apoptosis in human oral cancer cells via p38”. Oral Diseases 18 (5): 513–9. (July 2012). doi:10.1111/j.1601-0825.2012.01905.x. PMID 22309674.
- ^ “TrkC expression predicts good clinical outcome in primitive neuroectodermal brain tumors”. Journal of Clinical Oncology 18 (5): 1027–35. (March 2000). doi:10.1200/jco.2000.18.5.1027. PMID 10694553.
- ^ “NTRK3 is a potential tumor suppressor gene commonly inactivated by epigenetic mechanisms in colorectal cancer”. PLOS Genetics 9 (7): e1003552. (2013-07-11). doi:10.1371/journal.pgen.1003552. PMC 3708790. PMID 23874207.
- ^ “Detection of aberrant methylated SEPT9 and NTRK3 genes in sporadic colorectal cancer patients as a potential diagnostic biomarker”. Oncology Letters 12 (6): 5335–5343. (December 2016). doi:10.3892/ol.2016.5327. PMC 5228494. PMID 28105243.
- ^ “Prognostic CpG methylation biomarkers identified by methylation array in esophageal squamous cell carcinoma patients”. International Journal of Medical Sciences 11 (8): 779–87. (2014). doi:10.7150/ijms.7405. PMC 4057483. PMID 24936140.
- ^ “Evaluating entrectinib as a treatment option for non-small cell lung cancer”. Expert Opinion on Pharmacotherapy 21 (16): 1935–1942. (November 2020). doi:10.1080/14656566.2020.1798932. PMID 32736487.
- ^ “FDA Approval Summary: Entrectinib for the Treatment of NTRK gene Fusion Solid Tumors”. Clinical Cancer Research 27 (4): 928–932. (February 2021). doi:10.1158/1078-0432.CCR-20-2771. PMID 32967940.
- ^ “Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis”. Nature Communications 5 (5209): 5209. (November 2014). doi:10.1038/ncomms6209. PMC 4239663. PMID 25385546.
- ^ Lamballe, L; Klein, R; Barbecid, M (6 September 1991). “TrkC, a new member of the TrkC family of tyrosine protein kinases, is a receptor for Neurotrophin-3”. Cell 66 (5): 967–979. doi:10.1016/0092-8674(91)90442-2. PMID 1653651.
- ^ Philo, J; Talvenheimo, J; Wen, J; Rosenfeld, R; Welcher, A; Arakawa, T (11 November 1994). “Interactions of Neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and the NT-3. BDNF heterodimer with the extracellular domains of the TrkB and TrkC receptors”. Journal of Biological Chemistry 269 (45): 27840–27846. doi:10.1016/S0021-9258(18)46863-9. PMID 7961713.
- ^ “TrkC isoforms with inserts in the kinase domain show impaired signaling responses”. The Journal of Biological Chemistry 271 (10): 5691–7. (March 1996). doi:10.1074/jbc.271.10.5691. PMID 8621434.
- ^ “Neurotrophins: roles in neuronal development and function”. Annual Review of Neuroscience 24: 677–736. (March 2001). doi:10.1146/annurev.neuro.24.1.677. PMC 2758233. PMID 11520916.
- ^ “Mutations in NTRK3 suggest a novel signaling pathway in human congenital heart disease”. Human Mutation 35 (12): 1459–68. (December 2014). doi:10.1002/humu.22688. PMC 4247247. PMID 25196463.
- ^ “TrkC binds to the type II TGF-beta receptor to suppress TGF-beta signaling”. Oncogene 26 (55): 7684–91. (December 2007). doi:10.1038/sj.onc.1210571. PMID 17546043.
- ^ “Dok5 is substrate of TrkB and TrkC receptors and involved in neurotrophin induced MAPK activation”. Cellular Signalling 18 (11): 1995–2003. (November 2006). doi:10.1016/j.cellsig.2006.03.007. PMID 16647839.
- ^ “TrkC binds to the bone morphogenetic protein type II receptor to suppress bone morphogenetic protein signaling”. Cancer Research 67 (20): 9869–77. (October 2007). doi:10.1158/0008-5472.CAN-07-0436. PMID 17942918.
- ^ “Neurotrophin-3 and brain-derived neurotrophic factor activate multiple signal transduction events but are not survival factors for hippocampal pyramidal neurons”. Journal of Neurochemistry 67 (3): 952–63. (September 1996). doi:10.1046/j.1471-4159.1996.67030952.x. PMID 8752100.
- ^ “Early BDNF, NT-3, and NT-4 signaling events”. Experimental Neurology 159 (1): 297–308. (September 1999). doi:10.1006/exnr.1999.7148. PMID 10486198.
- ^ “Selective small molecule peptidomimetic ligands of TrkC and TrkA receptors afford discrete or complete neurotrophic activities”. Chemistry & Biology 12 (9): 1015–28. (September 2005). doi:10.1016/j.chembiol.2005.06.015. PMID 16183026.
- ^ “A peptidomimetic of NT-3 acts as a TrkC antagonist”. Peptides 30 (10): 1833–9. (October 2009). doi:10.1016/j.peptides.2009.07.015. PMC 2755609. PMID 19647025.
[続きの解説]
「トロポミオシン受容体キナーゼC」の続きの解説一覧
- 1 トロポミオシン受容体キナーゼCとは
- 2 トロポミオシン受容体キナーゼCの概要
- 3 機能
- 4 がんにおける役割
- 5 相互作用
- トロポミオシン受容体キナーゼCのページへのリンク
