NFAT5
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/05/12 02:55 UTC 版)
NFAT5（nuclear factor of activated T-cells 5）またはTonEBP（tonicity-responsive enhancer binding protein）は、浸透圧ストレスに関与する遺伝子の発現を調節する転写因子であり、ヒトではNFAT5遺伝子にコードされる[5]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000102908 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003847 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ a b “Entrez Gene: NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive”. 2022年4月2日閲覧。
- ^ “TonEBP stimulates multiple cellular pathways for adaptation to hypertonic stress: Organic osmolyte-dependent and -independent pathways”. AJP: Renal Physiology 300 (3): F707–F715. (2011). doi:10.1152/ajprenal.00227.2010. PMC 3064130. PMID 21209002.
- ^ “Tonicity-responsive enhancer binding protein, a Rel-like protein that stimulates transcription in response to hypertonicity”. Proc Natl Acad Sci USA 96 (5): 2538–2542. (1999). Bibcode: 1999PNAS...96.2538M. doi:10.1073/pnas.96.5.2538. PMC 26820. PMID 10051678.
- ^ a b c d “NFAT5 induction and its role in hyperosmolar stressed human limbal epithelial cells”. Invest. Ophthalmol. Vis. Sci. 49 (5): 1827–1835. (2008). doi:10.1167/iovs.07-1142. PMID 18436816.
- ^ a b “Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression”. Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2392–7. (February 2004). Bibcode: 2004PNAS..101.2392L. doi:10.1073/pnas.0308703100. PMC 356961. PMID 14983020.
- ^ “Transgenic mice expressing dominant-negative osmotic-response element-binding protein (OREBP) in lens exhibit fiber cell elongation defect associated with increased DNA breaks”. J. Biol. Chem. 280 (20): 19986–91. (May 2005). doi:10.1074/jbc.M501689200. PMID 15774462.
- ^ a b “NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun”. Proc. Natl. Acad. Sci. U.S.A. 96 (13): 7214–9. (June 1999). Bibcode: 1999PNAS...96.7214L. doi:10.1073/pnas.96.13.7214. PMC 22056. PMID 10377394.
- ^ a b c “Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5”. Sci Signal 2 (57): ra5. (2009). doi:10.1126/scisignal.2000081. PMC 2856329. PMID 19211510.
- ^ “Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways”. Mol. Cell. Biol. 25 (7): 2733–43. (April 2005). doi:10.1128/MCB.25.7.2733-2743.2005. PMC 1061651. PMID 15767678.
[続きの解説]
「NFAT5」の続きの解説一覧
- 1 NFAT5とは
- 2 NFAT5の概要
- 3 浸透圧ストレス
- 4 構造
- 5 関連文献
- 6 外部リンク
- NFAT5のページへのリンク
