XIAP
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/07/14 02:01 UTC 版)
XIAP（X-linked inhibitor of apoptosis）、IAP3（inhibitor of apoptosis protein）またはBIRC4（baculoviral IAP repeat-containing protein 4）は、アポトーシスによる細胞死を停止するタンパク質である。ヒトでは、XIAPはX染色体に位置するXIAP遺伝子にコードされる[4][5]。
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025860 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ a b c d e f g “Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes”. Nature 379 (6563): 349–53. (January 1996). Bibcode: 1996Natur.379..349L. doi:10.1038/379349a0. PMID 8552191.
- ^ “A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors”. The EMBO Journal 15 (11): 2685–94. (June 1996). doi:10.1002/j.1460-2075.1996.tb00629.x. PMC 450204. PMID 8654366.
- ^ “Functional characterization of the X-linked inhibitor of apoptosis (XIAP) internal ribosome entry site element: role of La autoantigen in XIAP translation”. Molecular and Cellular Biology 20 (13): 4648–57. (July 2000). doi:10.1128/MCB.20.13.4648-4657.2000. PMC 85872. PMID 10848591.
- ^ a b c d e f g “Human IAP-like protein regulates programmed cell death downstream of Bcl-xL and cytochrome c”. Molecular and Cellular Biology 18 (1): 608–15. (January 1998). doi:10.1128/MCB.18.1.608. PMC 121528. PMID 9418907.
- ^ a b c d “IAP family proteins--suppressors of apoptosis”. Genes & Development 13 (3): 239–52. (February 1999). doi:10.1101/gad.13.3.239. PMID 9990849.
- ^ a b c “Upstream regulatory role for XIAP in receptor-mediated apoptosis”. Molecular and Cellular Biology 24 (16): 7003–14. (August 2004). doi:10.1128/MCB.24.16.7003-7014.2004. PMC 479745. PMID 15282301.
- ^ “Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain”. Cell 104 (5): 781–90. (March 2001). doi:10.1016/S0092-8674(01)00273-2. PMID 11257231.
- ^ “Conformational characterization of full-length X-chromosome-linked inhibitor of apoptosis protein (XIAP) through an integrated approach”. IUCrJ 6 (Pt 5): 948–957. (September 2019). doi:10.1107/S205225251901073X. PMC 6760453. PMID 31576227.
- ^ a b c “X-linked IAP is a direct inhibitor of cell-death proteases”. Nature 388 (6639): 300–4. (July 1997). Bibcode: 1997Natur.388..300D. doi:10.1038/40901. PMID 9230442.
- ^ a b c Gewies A (2003年). “Introduction to Apoptosis”. CellDeath.de. 2008年8月12日閲覧。
- ^ “Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family”. EMBO Reports 7 (10): 988–94. (October 2006). doi:10.1038/sj.embor.7400795. PMC 1618369. PMID 17016456.
- ^ “Targeting apoptosis in prostate cancer: focus on caspases and inhibitors of apoptosis proteins”. BJU International 96 Suppl 2: 30–4. (December 2005). doi:10.1111/j.1464-410X.2005.05944.x. PMID 16359436.
- ^ a b “Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease”. Genetics in Medicine 13 (3): 255–62. (March 2011). doi:10.1097/GIM.0b013e3182088158. PMID 21173700.
- ^ “OMIM Entry - # 300635 - LYMPHOPROLIFERATIVE SYNDROME, X-LINKED, 2; XLP2” (英語). omim.org. 2021年7月17日閲覧。
- ^ “XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome”. Nature 444 (7115): 110–4. (November 2006). Bibcode: 2006Natur.444..110R. doi:10.1038/nature05257. PMID 17080092.
- ^ a b “ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis”. The Journal of Biological Chemistry 277 (34): 30454–62. (August 2002). doi:10.1074/jbc.M203312200. PMID 12048196.
- ^ a b “Structural basis for the inhibition of caspase-3 by XIAP”. Cell 104 (5): 791–800. (March 2001). doi:10.1016/S0092-8674(01)00274-4. PMID 11257232.
- ^ a b “The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases”. The EMBO Journal 16 (23): 6914–25. (December 1997). doi:10.1093/emboj/16.23.6914. PMC 1170295. PMID 9384571.
- ^ a b “X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes”. The Journal of Biological Chemistry 276 (29): 27058–63. (July 2001). doi:10.1074/jbc.M102415200. PMID 11359776.
- ^ “Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death”. Proceedings of the National Academy of Sciences of the United States of America 98 (15): 8662–7. (July 2001). Bibcode: 2001PNAS...98.8662S. doi:10.1073/pnas.161506698. PMC 37492. PMID 11447297.
- ^ “The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites”. The Journal of Cell Biology 157 (1): 115–24. (April 2002). doi:10.1083/jcb.200108085. PMC 2173256. PMID 11927604.
- ^ “Towards a proteome-scale map of the human protein-protein interaction network”. Nature 437 (7062): 1173–8. (October 2005). Bibcode: 2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
- ^ a b “Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9”. The Journal of Biological Chemistry 279 (39): 40622–8. (September 2004). doi:10.1074/jbc.M405963200. PMID 15280366.
- ^ “IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases”. The EMBO Journal 17 (8): 2215–23. (April 1998). doi:10.1093/emboj/17.8.2215. PMC 1170566. PMID 9545235.
- ^ “Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family”. Molecular and Cellular Biology 21 (13): 4292–301. (July 2001). doi:10.1128/MCB.21.13.4292-4301.2001. PMC 87089. PMID 11390657.
- ^ a b “HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins”. The Journal of Biological Chemistry 277 (1): 445–54. (January 2002). doi:10.1074/jbc.M109891200. PMID 11604410.
- ^ “A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO”. The Journal of Biological Chemistry 278 (9): 7494–9. (February 2003). doi:10.1074/jbc.C200695200. PMID 12511567.
- ^ “Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis”. The Journal of Biological Chemistry 278 (25): 23130–40. (June 2003). doi:10.1074/jbc.M300957200. PMID 12660240.
- ^ “Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins”. Cell 102 (1): 43–53. (July 2000). doi:10.1016/S0092-8674(00)00009-X. PMID 10929712.
- ^ “The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein”. The Journal of Biological Chemistry 278 (40): 38699–706. (October 2003). doi:10.1074/jbc.M303179200. PMID 12865429.
- ^ “Neurotrophin receptor-interacting mage homologue is an inducible inhibitor of apoptosis protein-interacting protein that augments cell death”. The Journal of Biological Chemistry 276 (43): 39985–9. (October 2001). doi:10.1074/jbc.C100171200. PMID 11546791.
- ^ “XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2”. Cellular Signalling 20 (11): 2107–12. (November 2008). doi:10.1016/j.cellsig.2008.08.004. PMID 18761086.
- ^ “XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway”. The EMBO Journal 18 (1): 179–87. (January 1999). doi:10.1093/emboj/18.1.179. PMC 1171113. PMID 9878061.
- ^ “Identification of XAF1 as an antagonist of XIAP anti-Caspase activity”. Nature Cell Biology 3 (2): 128–33. (February 2001). doi:10.1038/35055027. PMID 11175744.
[続きの解説]
- XIAPのページへのリンク
