シンシチン-1
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2024/03/21 15:18 UTC 版)
シンシチン-1(英: syncytin-1)はヒトやその他の霊長類に存在するタンパク質で、ERVW-1遺伝子(endogenous retrovirus group W envelope member 1)によってコードされる。Everinとしても知られる。シンシチン-1は細胞融合タンパク質であり、胎盤発生に関する機能が最もよく特徴づけられている[3][4]。胎盤は胚の子宮への付着を助け、栄養を供給する役割を果たす。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000242950 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ “From ancestral infectious retroviruses to bona fide cellular genes: role of the captured syncytins in placentation”. Placenta 33 (9): 663–71. (September 2012). doi:10.1016/j.placenta.2012.05.005. PMID 22695103.
- ^ “The role of syncytins in human reproduction and reproductive organ cancers”. Reproduction (Cambridge, England) 152 (5): R167–78. (2016). doi:10.1530/REP-16-0031. PMID 27486264.
- ^ “Phylogeny of a novel family of human endogenous retrovirus sequences, HERV-W, in humans and other primates”. AIDS Research and Human Retroviruses 15 (17): 1529–33. (November 1999). doi:10.1089/088922299309810. PMID 10580403.
- ^ “Paleovirology of 'syncytins', retroviral env genes exapted for a role in placentation”. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 368 (1626): 20120507. (September 2013). doi:10.1098/rstb.2012.0507. PMC 3758191. PMID 23938756 .
- ^ “The endogenous retroviral locus ERVWE1 is a bona fide gene involved in hominoid placental physiology”. Proceedings of the National Academy of Sciences of the United States of America 101 (6): 1731–6. (2004). doi:10.1073/pnas.0305763101. PMC 341840. PMID 14757826 .
- ^ a b c “Synthesis, assembly, and processing of the Env ERVWE1/syncytin human endogenous retroviral envelope”. Journal of Virology 79 (9): 5585–93. (May 2005). doi:10.1128/JVI.79.9.5585-5593.2005. PMC 1082723. PMID 15827173 .
- ^ “ERVW-1 endogenous retrovirus group W member 1 [Homo sapiens (human)]”. Gene - NCBI. 2016年11月23日閲覧。
- ^ “Chromosomal distribution and coding capacity of the human endogenous retrovirus HERV-W family”. AIDS Research and Human Retroviruses 16 (8): 731–40. (May 2000). doi:10.1089/088922200308738. PMID 10826480.
- ^ “Cell fusion induced by ERVWE1 or measles virus causes cellular senescence”. Genes & Development 27 (21): 2356–66. (November 2013). doi:10.1101/gad.227512.113. PMC 3828521. PMID 24186980 .
- ^ “Syncytin-1 modulates placental trophoblast cell proliferation by promoting G1/S transition”. Cellular Signalling 25 (4): 1027–35. (April 2013). doi:10.1016/j.cellsig.2013.01.008. PMC 4644426. PMID 23333240 .
- ^ “The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors”. Journal of Virology 76 (13): 6442–52. (July 2002). doi:10.1128/JVI.76.13.6442-6452.2002. PMC 136247. PMID 12050356 .
- ^ “An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor”. Journal of Virology 74 (7): 3321–9. (April 2000). doi:10.1128/jvi.74.7.3321-3329.2000. PMC 111833. PMID 10708449 .
- ^ “Receptor interference groups of 20 retroviruses plating on human cells”. Virology 176 (1): 58–69. (May 1990). doi:10.1016/0042-6822(90)90230-O. PMID 1691887.
- ^ “The envelope glycoprotein of human endogenous retrovirus HERV-W induces cellular resistance to spleen necrosis virus” (英語). Archives of Virology 148 (4): 659–75. (April 2003). doi:10.1007/s00705-002-0960-x. PMID 12664292.
- ^ a b c “Human Endogenous Retroviruses as Pathogenic Factors in the Development of Schizophrenia”. Frontiers in Psychiatry 6: 183. (January 2015). doi:10.3389/fpsyt.2015.00183. PMC 4707225. PMID 26793126 .
- ^ “Mapping of receptor binding domains in the envelope protein of spleen necrosis virus”. Journal of Virology 69 (7): 4339–46. (July 1995). doi:10.1128/JVI.69.7.4339-4346.1995. PMC 189174. PMID 7769695 .
- ^ “Mutational analysis of the envelope protein of spleen necrosis virus”. Journal of Virology 70 (9): 6036–43. (September 1996). doi:10.1128/JVI.70.9.6036-6043.1996. PMC 190624. PMID 8709226 .
- ^ “N-linked glycosylation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino acid transporters determine their retroviral receptor functions”. Journal of Virology 77 (5): 2936–45. (March 2003). doi:10.1128/JVI.77.5.2936-2945.2003. PMC 149750. PMID 12584318 .
- ^ “C-Terminal truncations of syncytin-1 (ERVWE1 envelope) that increase its fusogenicity”. Biological Chemistry 387 (8): 1113–20. (August 2006). doi:10.1515/BC.2006.137. PMID 16895482.
- ^ “Syncytin-1 and glial cells missing a: hypoxia-induced deregulated gene expression along with disordered cell fusion in primary term human trophoblasts”. Gynecologic and Obstetric Investigation 68 (1): 9–18. (2009-01-01). doi:10.1159/000209396. PMID 19321927 .
- ^ “Syncytin 1 in the human placenta”. Placenta 33 (6): 460–6. (June 2012). doi:10.1016/j.placenta.2012.02.012. PMID 22381536.
- ^ “Analysis of transcribed human endogenous retrovirus W env loci clarifies the origin of multiple sclerosis-associated retrovirus env sequences”. Retrovirology 6: 37. (April 2009). doi:10.1186/1742-4690-6-37. PMC 2672075. PMID 19368703 .
- ^ “HERV-W-related RNA detected in plasma from individuals with recent-onset schizophrenia or schizoaffective disorder”. Molecular Psychiatry 9 (1): 12–3. (January 2004). doi:10.1038/sj.mp.4001439. PMID 14571258.
- 1 シンシチン-1とは
- 2 シンシチン-1の概要
- 3 構造
- 4 外部リンク
- シンシチン-1のページへのリンク