α‐リポ酸
分子式: | C8H14O2S2 |
その他の名称: | α-リポ酸、d-チオクト酸、α-Lipoic acid、d-Thioctic acid、[R,(+)]-1,2-Dithiolane-3-pentanoic acid、チオクト酸、Lipoic acid、Thioctic acid、リポ酸、(R)-チオクト酸、(R)-Thioctic acid、(R)-リポ酸、(R)-Lipoic acid、(R)-α-Lipoic acid、(R)-α-リポ酸、リポアラン、Lypoaran、(R)-(+)-α-リポ酸 |
体系名: | (R)-1,2-ジチオラン-3α-ペンタン酸、(R)-1,2-ジチオラン-3-ペンタン酸、[R,(+)]-1,2-ジチオラン-3-ペンタン酸 |
αリポ酸
α-リポ酸
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2023/12/07 20:48 UTC 版)
リポ酸(lipoic acid、別名:α-リポ酸、チオクト酸)は、多数の酵素の補助因子として欠かせない光学活性のある有機化合物である。抗酸化物質。カルボキシル基と環状のジスルフィドを含んでいる。生物学上で重要なのはR体である。リポ酸の酸化体はβ-リポ酸、還元体はジヒドロリポ酸である。
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- ^ a b “Alpha-lipoic acid supplement in obesity treatment: A systematic review and meta-analysis of clinical trials”. Clin Nutr 37 (2): 419–428. (April 2018). doi:10.1016/j.clnu.2017.06.002. PMID 28629898.
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- ^ Perham RN (2000). “Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions”. Annu Rev Biochem 69: 961-1004. PMID 10966480. [1]
- ^ a b “The protective effect of lipoic acid on selected cardiovascular diseases caused by age-related oxidative stress”. Oxid Med Cell Longev 2015: 313021. (2015). doi:10.1155/2015/313021. PMC 4407629. PMID 25949771 .
- ^ Levtova, Alina; Waters, Paula J.; Buhas, Daniela; Lévesque, Sébastien; Auray‐Blais, Christiane; Clarke, Joe T.R.; Laframboise, Rachel; Maranda, Bruno et al. (2019-01). “Combined malonic and methylmalonic aciduria due to ACSF3 mutations: Benign clinical course in an unselected cohort” (英語). Journal of Inherited Metabolic Disease 42 (1): 107–116. doi:10.1002/jimd.12032. ISSN 0141-8955 .
- ^ a b c Wehbe, Zeinab; Behringer, Sidney; Alatibi, Khaled; Watkins, David; Rosenblatt, David; Spiekerkoetter, Ute; Tucci, Sara (2019-11). “The emerging role of the mitochondrial fatty-acid synthase (mtFASII) in the regulation of energy metabolism” (英語). Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1864 (11): 1629–1643. doi:10.1016/j.bbalip.2019.07.012 .
- ^ Hiltunen, J. Kalervo; Autio, Kaija J.; Schonauer, Melissa S.; Kursu, V.A. Samuli; Dieckmann, Carol L.; Kastaniotis, Alexander J. (2010-06). “Mitochondrial fatty acid synthesis and respiration” (英語). Biochimica et Biophysica Acta (BBA) - Bioenergetics 1797 (6-7): 1195–1202. doi:10.1016/j.bbabio.2010.03.006 .
- ^ Beitner H (October 2003). “Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin”. Br. J. Dermatol. (4): 841–9. PMID 14616378.
- ^ Perricone, N (2000). “Topical 5% alpha lipoic acid cream in the treatment of cutaneous rhytids”. Aesthetic Surgery Journal 20 (3): 218–222. doi:10.1016/S1090-820X(00)70020-3 .
- ^ α-リポ酸(チオクト酸) - 素材情報データベース<有効性情報>(国立健康・栄養研究所)
- 1 α-リポ酸とは
- 2 α-リポ酸の概要
- 3 役割
- 4 安全性
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