PLK1
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/07/30 03:59 UTC 版)
PLK1（polo-like kinase 1）またはSTPK13（serine/threonine protein kinase 13）は、ヒトではPLK1遺伝子によってコードされる酵素（プロテインキナーゼ）である[5]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000166851 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030867 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors”. Proceedings of the National Academy of Sciences of the United States of America 91 (5): 1736–40. (March 1994). Bibcode: 1994PNAS...91.1736H. doi:10.1073/pnas.91.5.1736. PMC 43238. PMID 8127874.
- ^ “The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex”. The EMBO Journal 22 (21): 5757–68. (November 2003). doi:10.1093/emboj/cdg558. PMC 275415. PMID 14592974.
- ^ “Self-regulated mechanism of Plk1 localization to kinetochores: lessons from the Plk1-PBIP1 interaction”. Cell Division 3: 4. (January 2008). doi:10.1186/1747-1028-3-4. PMC 2263035. PMID 18215321.
- ^ “Polo-like kinases: a team in control of the division”. Cell Cycle 5 (8): 853–64. (April 2006). doi:10.4161/cc.5.8.2692. PMID 16627997.
- ^ Lee, Brian H.; Amon, Angelika (2003-04-18). “Role of Polo-like kinase CDC5 in programming meiosis I chromosome segregation”. Science (New York, N.Y.) 300 (5618): 482–486. doi:10.1126/science.1081846. ISSN 1095-9203. PMID 12663816.
- ^ “Cell cycle kinases in cancer”. Current Opinion in Genetics & Development 17 (1): 60–5. (February 2007). doi:10.1016/j.gde.2006.12.008. PMID 17208431.
- ^ “Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells”. Proceedings of the National Academy of Sciences of the United States of America 100 (10): 5789–94. (May 2003). Bibcode: 2003PNAS..100.5789L. doi:10.1073/pnas.1031523100. PMC 156279. PMID 12732729.
- ^ Downward, Julian (2009-08-27). “Finding the weakness in cancer”. The New England Journal of Medicine 361 (9): 922–924. doi:10.1056/NEJMcibr0905242. ISSN 1533-4406. PMID 19710492.
- ^ “A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene”. Cell 137 (5): 835–48. (May 2009). doi:10.1016/j.cell.2009.05.006. PMC 2768667. PMID 19490893.
- ^ “Spotlight on Volasertib: Preclinical and Clinical Evaluation of a Promising Plk1 Inhibitor”. Medicinal Research Reviews 36 (4): 749–86. (July 2016). doi:10.1002/med.21392. PMID 27140825.
- ^ “Polo-like kinase 1 inhibition diminishes acquired resistance to epidermal growth factor receptor inhibition in non-small cell lung cancer with T790M mutations”. Oncotarget 7 (30): 47998–48010. (July 2016). doi:10.18632/oncotarget.10332. PMC 5216995. PMID 27384992.
- ^ “Mutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell-cycle inhibitors”. Cancer Letters 392: 71–82. (April 2017). doi:10.1016/j.canlet.2017.01.024. PMC 5404895. PMID 28126323.
- ^ a b “Non-canonical cMet regulation by vimentin mediates Plk1 inhibitor-induced apoptosis”. EMBO Molecular Medicine 11 (5). (May 2019). doi:10.15252/emmm.201809960. PMC 6505578. PMID 31040125.
- ^ “Preclinical pharmacokinetic and pharmacodynamic evaluation of novel anticancer agents, ON01910.Na (Rigosertib, Estybon™) and ON013105, for brain tumor chemotherapy”. Pharmaceutical Research 29 (9): 2499–511. (September 2012). doi:10.1007/s11095-012-0780-y. PMID 22678771.
- ^ “Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody”. The Journal of Biological Chemistry 278 (10): 8468–75. (March 2003). doi:10.1074/jbc.M211202200. PMID 12493754.
- ^ “A role for Plk1 phosphorylation of NudC in cytokinesis”. Developmental Cell 5 (1): 127–38. (July 2003). doi:10.1016/s1534-5807(03)00186-2. PMID 12852857.
- ^ “The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins”. Genes & Development 12 (5): 706–20. (March 1998). doi:10.1101/gad.12.5.706. PMC 316589. PMID 9499405.
- ^ “Function of WW domains as phosphoserine- or phosphothreonine-binding modules”. Science 283 (5406): 1325–8. (February 1999). Bibcode: 1999Sci...283.1325L. doi:10.1126/science.283.5406.1325. PMID 10037602.
- ^ “Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression”. Oncogene 23 (4): 865–72. (January 2004). doi:10.1038/sj.onc.1207223. PMID 14647413.
- ^ “M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex”. The Journal of Biological Chemistry 278 (38): 35979–87. (September 2003). doi:10.1074/jbc.M210659200. PMID 12815053.
- ^ a b c d “Polo-like kinase interacts with proteasomes and regulates their activity”. Cell Growth & Differentiation 12 (1): 29–37. (January 2001). PMID 11205743.
- ^ “Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner”. Human Molecular Genetics 15 (2): 287–97. (January 2006). doi:10.1093/hmg/ddi444. PMID 16339216.
- ^ “Polo-like Kinase 1 Regulates Vimentin Phosphorylation at Ser-56 and Contraction in Smooth Muscle”. The Journal of Biological Chemistry 291 (45): 23693–23703. (November 2016). doi:10.1074/jbc.M116.749341. PMC 5095422. PMID 27662907.
- ^ “Computational analysis of phosphopeptide binding to the polo-box domain of the mitotic kinase PLK1 using molecular dynamics simulation”. PLOS Computational Biology 6 (8): e1000880. (August 2010). Bibcode: 2010PLSCB...6E0880H. doi:10.1371/journal.pcbi.1000880. PMC 2920843. PMID 20711360.
[続きの解説]
- PLK1のページへのリンク
