ポロ様キナーゼ
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/05/25 22:30 UTC 版)
ポロ様キナーゼ（ポロようキナーゼ、英: Polo-like kinase、略称: Plk）は細胞周期を調節するセリン/スレオニンキナーゼであり、有糸分裂の開始、終結、紡錘体の形成、細胞質分裂、減数分裂に関与する[1]。Plkはショウジョウバエ、出芽酵母、分裂酵母のゲノムには1つしかコードされていないが（それぞれPolo、Cdc5、Plo1）、脊椎動物ではPlk1（ツメガエルではPlx1）、Plk2/Snk（Plx2）、Plk3/Prk/FnK（Plx3）、Plk4/Sak、Plk5を含む、多数のPlkファミリーのメンバーが存在する[1]。Plkファミリーのメンバーの中では、哺乳類のPlk1が最も広く研究されている。有糸分裂と細胞質分裂の間、Plkは中心体、キネトコア、中央紡錘体を含むいくつかの構造体と結合している。
- ^ a b c d e Barr, Francis A.; Silljé, Herman H. W.; Nigg, Erich A. (2004-06). “Polo-like kinases and the orchestration of cell division”. Nature Reviews. Molecular Cell Biology 5 (6): 429–440. doi:10.1038/nrm1401. ISSN 1471-0072. PMID 15173822.
- ^ Fenton, Brian; Glover, David M. (1993). “A conserved mitotic kinase active at late anaphase—telophase in syncytial Drosophila embryos”. Nature 363 (6430): 637–40. Bibcode: 1993Natur.363..637F. doi:10.1038/363637a0. PMID 8510757.
- ^ a b c Archambault, Vincent; Glover, David M. (2009-04). “Polo-like kinases: conservation and divergence in their functions and regulation”. Nature Reviews. Molecular Cell Biology 10 (4): 265–275. doi:10.1038/nrm2653. ISSN 1471-0080. PMID 19305416.
- ^ Qian, Y. W.; Erikson, E.; Maller, J. L. (1998-11-27). “Purification and cloning of a protein kinase that phosphorylates and activates the polo-like kinase Plx1”. Science (New York, N.Y.) 282 (5394): 1701–1704. doi:10.1126/science.282.5394.1701. ISSN 0036-8075. PMID 9831560.
- ^ Elia, Andrew E. H.; Cantley, Lewis C.; Yaffe, Michael B. (2003-02-21). “Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates”. Science (New York, N.Y.) 299 (5610): 1228–1231. doi:10.1126/science.1079079. ISSN 1095-9203. PMID 12595692.
- ^ Shirayama, M.; Zachariae, W.; Ciosk, R.; Nasmyth, K. (1998-03-02). “The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae”. The EMBO journal 17 (5): 1336–1349. doi:10.1093/emboj/17.5.1336. ISSN 0261-4189. PMC: 1170482. PMID 9482731.
- ^ Kumagai, A.; Dunphy, W. G. (1996-09-06). “Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts”. Science (New York, N.Y.) 273 (5280): 1377–1380. doi:10.1126/science.273.5280.1377. ISSN 0036-8075. PMID 8703070.
- ^ Toyoshima-Morimoto, Fumiko; Taniguchi, Eri; Nishida, Eisuke (2002-04). “Plk1 promotes nuclear translocation of human Cdc25C during prophase”. EMBO reports 3 (4): 341–348. doi:10.1093/embo-reports/kvf069. ISSN 1469-221X. PMC: 1084057. PMID 11897663.
- ^ McNally, Karen Perry; Buster, Dan; McNally, Francis J. (2002-12). “Katanin-mediated microtubule severing can be regulated by multiple mechanisms”. Cell Motility and the Cytoskeleton 53 (4): 337–349. doi:10.1002/cm.10080. ISSN 0886-1544. PMID 12378543.
- ^ Yarm, Frederic R. (2002-09). “Plk phosphorylation regulates the microtubule-stabilizing protein TCTP”. Molecular and Cellular Biology 22 (17): 6209–6221. doi:10.1128/mcb.22.17.6209-6221.2002. ISSN 0270-7306. PMC: 134017. PMID 12167714.
- ^ Budde, P. P.; Kumagai, A.; Dunphy, W. G.; Heald, R. (2001-04-02). “Regulation of Op18 during spindle assembly in Xenopus egg extracts”. The Journal of Cell Biology 153 (1): 149–158. doi:10.1083/jcb.153.1.149. ISSN 0021-9525. PMC: 2185528. PMID 11285281.
- ^ Hansen, David V.; Loktev, Alexander V.; Ban, Kenneth H.; Jackson, Peter K. (2004-12). “Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1”. Molecular Biology of the Cell 15 (12): 5623–5634. doi:10.1091/mbc.e04-07-0598. ISSN 1059-1524. PMC: PMC532041. PMID 15469984.
- ^ Alexandru, G.; Uhlmann, F.; Mechtler, K.; Poupart, M. A.; Nasmyth, K. (2001-05-18). “Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast”. Cell 105 (4): 459–472. doi:10.1016/s0092-8674(01)00362-2. ISSN 0092-8674. PMID 11371343.
- ^ Clyne, Rosemary K.; Katis, Vittorio L.; Jessop, Lea; Benjamin, Kirsten R.; Herskowitz, Ira; Lichten, Michael; Nasmyth, Kim (2003-05). “Polo-like kinase Cdc5 promotes chiasmata formation and cosegregation of sister centromeres at meiosis I”. Nature Cell Biology 5 (5): 480–485. doi:10.1038/ncb977. ISSN 1465-7392. PMID 12717442.
- ^ Mulvihill, D. P.; Petersen, J.; Ohkura, H.; Glover, D. M.; Hagan, I. M. (1999-08). “Plo1 kinase recruitment to the spindle pole body and its role in cell division in Schizosaccharomyces pombe”. Molecular Biology of the Cell 10 (8): 2771–2785. doi:10.1091/mbc.10.8.2771. ISSN 1059-1524. PMC: PMC25513. PMID 10436027.
- ^ Bähler, J.; Steever, A. B.; Wheatley, S.; Wang, Y. l; Pringle, J. R.; Gould, K. L.; McCollum, D. (1998-12-14). “Role of polo kinase and Mid1p in determining the site of cell division in fission yeast”. The Journal of Cell Biology 143 (6): 1603–1616. doi:10.1083/jcb.143.6.1603. ISSN 0021-9525. PMC: 2132972. PMID 9852154.
- ^ Neef, Rüdiger; Preisinger, Christian; Sutcliffe, Josephine; Kopajtich, Robert; Nigg, Erich A.; Mayer, Thomas U.; Barr, Francis A. (2003-09-01). “Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis”. The Journal of Cell Biology 162 (5): 863–875. doi:10.1083/jcb.200306009. ISSN 0021-9525. PMC: 2172827. PMID 12939256.
- ^ Yoshida, Satoshi; Kono, Keiko; Lowery, Drew M.; Bartolini, Sara; Yaffe, Michael B.; Ohya, Yoshikazu; Pellman, David (2006-07-07). “Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis”. Science (New York, N.Y.) 313 (5783): 108–111. doi:10.1126/science.1126747. ISSN 1095-9203. PMID 16763112.
[続きの解説]
「ポロ様キナーゼ」の続きの解説一覧
- 1 ポロ様キナーゼとは
- 2 ポロ様キナーゼの概要
- 3 細胞質分裂
- ポロ様キナーゼのページへのリンク
