MiRNA-21とは - わかりやすく解説 Weblio辞書

MiRNA-21

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/09/18 09:35 UTC 版)

マイクロRNA-21(=miR-21、has-mir-21、miRNA21)(*以下、miR-21と表記)とは、MIR21遺伝子によってコードされている哺乳類のマイクロRNAである。^[3] miR-21は哺乳類におけるマイクロRNAでもごく初期に同定されたマイクロRNAのうちのひとつである。成熟miR-21の配列は進化の過程で強く保存されている。ヒトmiR-21遺伝子は液胞膜タンパクと呼ばれるTMEM49遺伝子によって、第17番染色体長腕(17q23.2)の正鎖に存在している。miR-21はコード遺伝子の転写方向におけるイントロン領域に存在している。にもかかわらず、自身のプロモーター領域を有しており、pri-miR-21と呼ばれる約3400塩基の独自の初期転写産物を生成する。ステムループ構造を有する前駆体miR-21(pre-miR-21)はpri-miR-21の2445～2516番の塩基に存在している。

脚注

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000284190 - Ensembl, May 2017
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