DNAトポイソメラーゼI
TOP1
(DNAトポイソメラーゼI から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/09/25 07:10 UTC 版)
TOP1またはDNAトポイソメラーゼI（英: DNA topoisomerase I）は、ヒトではTOP1遺伝子にコードされる酵素である。DNAトポイソメラーゼであり、DNA一本鎖の一過的な切断と再結合を触媒する。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000198900 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070544 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ a b c d “Drugging topoisomerases: lessons and challenges”. ACS Chem. Biol. 8 (1): 82–95. (2013). doi:10.1021/cb300648v. PMC 3549721. PMID 23259582.
- ^ “Entrez Gene: TOP1 topoisomerase (DNA) I”. 2020年12月14日閲覧。
- ^ a b c “DNA topoisomerases: structure, function, and mechanism”. Annu. Rev. Biochem. 70: 369–413. (2001). doi:10.1146/annurev.biochem.70.1.369. PMID 11395412.
- ^ “A kinetic clutch governs religation by type IB topoisomerases and determines camptothecin sensitivity”. Proc. Natl. Acad. Sci. U.S.A. 109 (40): 16125–30. (2012). doi:10.1073/pnas.1206480109. PMC 3479559. PMID 22991469.
- ^ a b “Perspectives on biologically active camptothecin derivatives”. Med Res Rev 35 (4): 753–89. (2015). doi:10.1002/med.21342. PMC 4465867. PMID 25808858.
- ^ Nagy, Ádám; Pongor, Lőrinc Sándor; Szabó, András; Santarpia, Mariacarmela; Győrffy, Balázs (2017-02-15). “KRAS driven expression signature has prognostic power superior to mutation status in non-small cell lung cancer”. International Journal of Cancer 140 (4): 930–937. doi:10.1002/ijc.30509. ISSN 1097-0215. PMC 5299512. PMID 27859136.
- ^ a b c “Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer”. Proc. Natl. Acad. Sci. U.S.A. 103 (23): 8822–7. (2006). doi:10.1073/pnas.0600645103. PMC 1466544. PMID 16723399.
- ^ a b “MRE11-deficiency associated with improved long-term disease free survival and overall survival in a subset of stage III colon cancer patients in randomized CALGB 89803 trial”. PLOS ONE 9 (10): e108483. (2014). doi:10.1371/journal.pone.0108483. PMC 4195600. PMID 25310185.
- ^ a b “ATM expression predicts Veliparib and Irinotecan sensitivity in gastric cancer by mediating P53 independent regulation of cell cycle and apoptosis”. Mol. Cancer Ther. 15 (12): 3087–3096. (2016). doi:10.1158/1535-7163.MCT-15-1002. PMID 27638859.
- ^ a b “Identification of cetrimonium bromide and irinotecan as compounds with synthetic lethality against NDRG1 deficient prostate cancer cells”. Cancer Biol. Ther. 14 (5): 401–10. (2013). doi:10.4161/cbt.23759. PMC 3672184. PMID 23377825.
- ^ “mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice”. Aging Cell 16 (1): 52–60. (2016). doi:10.1111/acel.12525. PMC 5242303. PMID 27618784.
- ^ a b Subramanian, D.; Rosenstein, B. S.; Muller, M. T. (1998-03-01). “Ultraviolet-induced DNA damage stimulates topoisomerase I-DNA complex formation in vivo: possible relationship with DNA repair”. Cancer Research 58 (5): 976–984. ISSN 0008-5472. PMID 9500459.
- ^ “Interaction between the N-terminal domain of human DNA topoisomerase I and the arginine-serine domain of its substrate determines phosphorylation of SF2/ASF splicing factor”. Nucleic Acids Research 26 (12): 2955–62. (Jun 1998). doi:10.1093/nar/26.12.2955. PMC 147637. PMID 9611241.
- ^ “The RNA splicing factor ASF/SF2 inhibits human topoisomerase I mediated DNA relaxation”. Journal of Molecular Biology 322 (4): 677–86. (Sep 2002). doi:10.1016/s0022-2836(02)00815-x. PMID 12270705.
- ^ a b “Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I”. BMC Genomics 3: 1. (2002). doi:10.1186/1471-2164-3-1. PMC 64781. PMID 11818025.
- ^ “Interaction between the N-terminus of human topoisomerase I and SV40 large T antigen”. Nucleic Acids Research 26 (7): 1841–7. (Apr 1998). doi:10.1093/nar/26.7.1841. PMC 147454. PMID 9512561.
- ^ “Identification of a nucleolin binding site in human topoisomerase I”. The Journal of Biological Chemistry 271 (4): 1993–7. (Jan 1996). doi:10.1074/jbc.271.4.1993. PMID 8567649.
- ^ “The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53”. Proceedings of the National Academy of Sciences of the United States of America 96 (18): 10355–60. (Aug 1999). doi:10.1073/pnas.96.18.10355. PMC 17892. PMID 10468612.
- ^ “Subnuclear distribution of topoisomerase I is linked to ongoing transcription and p53 status”. Proceedings of the National Academy of Sciences of the United States of America 99 (3): 1235–40. (Feb 2002). doi:10.1073/pnas.022631899. PMC 122173. PMID 11805286.
- ^ “SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage”. Proceedings of the National Academy of Sciences of the United States of America 97 (8): 4046–51. (Apr 2000). doi:10.1073/pnas.080536597. PMC 18143. PMID 10759568.
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