Corynebacterium glutamicumとは？わかりやすく解説

Corynebacterium glutamicum
分類
学名
	Corynebacterium glutamicum; (Kinoshita et al. 1958)
シノニム
	Brevibacterium divaricatum Su and Yamada 1960 (Approved Lists 1980); "Brevibacterium flavum" Okumura et al. 1962; Corynebacterium lilium Lee and Good 1963 (Approved Lists 1980); "Micrococcus glutamicus" Kinoshita et al. 1958;

Corynebacterium glutamicum は、アミノ酸^[3]^[4]のグルタミン酸とリジン^[5]の工業生産に利用されているグラム陽性菌である。コリネ菌、グルタミン酸生産菌とも呼ばれる。もともとはL-グルタミン酸を分泌する生物のスクリーニングで発見されたが、他の様々なアミノ酸やアミノ酸誘導体を産生する変異体も発見されている^[6]。

産業上の重要性から、C. glutamicumの複数のクローンが業界および学術グループによってシークエンシングされている^[5]。さらに、C. glutamicum ATCC 13032株のRNAシーケンスによって小分子RNA（英語版）データが得られている^[7]。この菌株の代謝は再構築されており、ゲノムスケールの代謝モデルの形で利用可能である^[8]。

出典

^ Tatsumi, Nami; Inui, Masayuki (14 August 2012). Corynebacterium glutamicum: Biology and Biotechnology. Springer Science & Business Media. p. 336. ISBN 978-3-642-29857-8
^ Lv, Yangyong; Juanjun, Liao; Wu, Zhanhong et al. (February 2012). “Genome Sequence of Corynebacterium glutamicum ATCC 14067, Which Provides Insight into Amino Acid Biosynthesis in Coryneform Bacteria”. Journal of Bacteriology 194 (3): 742–743. doi:10.1128/JB.06514-11. PMC 3264075. PMID 22247536.
^ Kinoshita, Shukuo; Udaka, Shigezo; Shimono, Masakazu (1957), “Studies on the amino acid fermentation. Part 1. Production of L-glutamic acid by various microorganisms”, Journal of General and Applied Microbiology 3 (3): 193–205, doi:10.2323/jgam.3.193, PMID 15965888
^ Udaka, Shigezo (1960), “Screening method for microorganisms accumulating metabolites and its use in the isolation of Micrococcus glutamicus”, Journal of Bacteriology 79 (5): 754–755, doi:10.1128/jb.79.5.754-755.1960, PMC 278770, PMID 13840150
^ ^a ^b Kalinowski, J; Bathe, B; Bartels, D et al. (4 September 2003). “The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of l-aspartate-derived amino acids and vitamins”. Journal of Biotechnology 104 (1–3): 5–25. doi:10.1016/S0168-1656(03)00154-8. PMID 12948626.
^ Zahoor A; Lindner SN; Wendisch VF (October 2012). “Metabolic Engineering of Corynebacterium glutamicum Aimed at Alternative Carbon Sources and New Products”. Computational and Structural Biotechnology Journal 3 (4): e201210004. doi:10.5936/csbj.201210004. PMC 3962153. PMID 24688664.
^ Mentz, Almut; Neshat, Armin; Pfeifer-Sancar, Katharina et al. (2013-10-19). “Comprehensive discovery and characterization of small RNAs in Corynebacterium glutamicum ATCC 13032”. BMC Genomics 14 (1): 714. doi:10.1186/1471-2164-14-714. ISSN 1471-2164. PMC 4046766. PMID 24138339.
^ Feierabend, Martina; Renz, Alina; Zelle, Elisabeth et al. (2021). “High-Quality Genome-Scale Reconstruction of Corynebacterium glutamicum ATCC 13032”. Frontiers in Microbiology 12 (10): 3432. doi:10.3389/fmicb.2021.750206. ISSN 1664-302X. PMC 8634658. PMID 34867870.

外部リンク

[1] Tatsumi, Nami; Inui, Masayuki (14 August 2012). Corynebacterium glutamicum: Biology and Biotechnology. Springer Science & Business Media. p. 336. ISBN 978-3-642-29857-8

[2] Lv, Yangyong; Juanjun, Liao; Wu, Zhanhong et al. (February 2012). “Genome Sequence of Corynebacterium glutamicum ATCC 14067, Which Provides Insight into Amino Acid Biosynthesis in Coryneform Bacteria”. Journal of Bacteriology 194 (3): 742–743. doi:10.1128/JB.06514-11. PMC 3264075. PMID 22247536.

[JGAM_1957-3] Kinoshita, Shukuo; Udaka, Shigezo; Shimono, Masakazu (1957), “Studies on the amino acid fermentation. Part 1. Production of L-glutamic acid by various microorganisms”, Journal of General and Applied Microbiology 3 (3): 193–205, doi:10.2323/jgam.3.193, PMID 15965888

[JBacteriol_1960-4] Udaka, Shigezo (1960), “Screening method for microorganisms accumulating metabolites and its use in the isolation of Micrococcus glutamicus”, Journal of Bacteriology 79 (5): 754–755, doi:10.1128/jb.79.5.754-755.1960, PMC 278770, PMID 13840150

[Kalinowski2003-5] Kalinowski, J; Bathe, B; Bartels, D et al. (4 September 2003). “The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of l-aspartate-derived amino acids and vitamins”. Journal of Biotechnology 104 (1–3): 5–25. doi:10.1016/S0168-1656(03)00154-8. PMID 12948626.

[Zahoor-6] Zahoor A; Lindner SN; Wendisch VF (October 2012). “Metabolic Engineering of Corynebacterium glutamicum Aimed at Alternative Carbon Sources and New Products”. Computational and Structural Biotechnology Journal 3 (4): e201210004. doi:10.5936/csbj.201210004. PMC 3962153. PMID 24688664.

[7] Mentz, Almut; Neshat, Armin; Pfeifer-Sancar, Katharina et al. (2013-10-19). “Comprehensive discovery and characterization of small RNAs in Corynebacterium glutamicum ATCC 13032”. BMC Genomics 14 (1): 714. doi:10.1186/1471-2164-14-714. ISSN 1471-2164. PMC 4046766. PMID 24138339.

[8] Feierabend, Martina; Renz, Alina; Zelle, Elisabeth et al. (2021). “High-Quality Genome-Scale Reconstruction of Corynebacterium glutamicum ATCC 13032”. Frontiers in Microbiology 12 (10): 3432. doi:10.3389/fmicb.2021.750206. ISSN 1664-302X. PMC 8634658. PMID 34867870.

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Corynebacterium glutamicumとは？わかりやすく解説

Corynebacterium glutamicum

出典

関連項目

外部リンク

「Corynebacterium glutamicum」の関連用語

Corynebacterium glutamicumとは？ わかりやすく解説

Corynebacterium glutamicum

出典

関連項目

外部リンク

急上昇のことば

「Corynebacterium glutamicum」の関連用語

Corynebacterium glutamicumとは？わかりやすく解説