サイクリンT1とは？わかりやすく解説

CCNT1
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	2PK2, 3BLH, 3BLQ, 3BLR, 3LQ5, 3MI9, 3MIA, 3MY1, 3TN8, 3TNH, 3TNI, 4BCF, 4BCG, 4BCH, 4BCI, 4BCJ, 4EC8, 4EC9, 4IMY, 4OGR, 4OR5
識別子
記号	CCNT1, CCNT, CYCT1, HIVE1, cyclin T1
外部ID	OMIM: 143055 MGI: 1328363 HomoloGene: 947 GeneCards: CCNT1
遺伝子の位置 (ヒト)
染色体	12番染色体 (ヒト)
終点	48,716,998 bp
遺伝子の位置 (マウス)
染色体	15番染色体 (マウス)
終点	98,468,804 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• DNA結合; • snRNA binding; • クロマチン結合; • 7SK snRNA binding; • cyclin-dependent protein serine/threonine kinase regulator activity; • 血漿タンパク結合; • RNA polymerase binding; • 転写因子結合; • protein serine/threonine kinase activity; • プロテインキナーゼ結合; • cyclin-dependent protein serine/threonine kinase activator activity;
細胞の構成要素	• 核質; • 核小体; • P-TEFb; • 細胞核; • cyclin-dependent protein kinase holoenzyme complex;
生物学的プロセス	• regulation of cyclin-dependent protein serine/threonine kinase activity; • negative regulation of mRNA polyadenylation; • regulation of transcription, DNA-templated; • transcription elongation from RNA polymerase II promoter; • transcription by RNA polymerase II; • 細胞分裂; • タンパク質リン酸化; • positive regulation of phosphorylation of RNA polymerase II C-terminal domain; • positive regulation of cyclin-dependent protein serine/threonine kinase activity; • positive regulation of viral transcription; • 細胞周期; • positive regulation of transcription by RNA polymerase II; • viral process; • transcription, DNA-templated; • snRNA transcription by RNA polymerase II; • regulation of transcription by RNA polymerase II; • positive regulation of DNA-templated transcription, elongation;
	出典:Amigo / QuickGO
オルソログ
	904
	12455
	ENSG00000129315
	ENSMUSG00000011960
	O60563
	Q9QWV9
	NM_001240; NM_001277842
	NM_009833; NM_001368702
	NP_001231; NP_001264771
	NP_033963; NP_001355631
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

サイクリンT1（英: cyclin T1）は、ヒトではCCNT1遺伝子にコードされるタンパク質である^[5]^[6]。

機能

CCNT1遺伝子にコードされるサイクリンT1タンパク質は、高度に保存されたサイクリンファミリーに属する。このファミリーのメンバーは、細胞周期を通じてそのタンパク質存在量に顕著な周期性がみられることで特徴づけられる。サイクリンはサイクリン依存性キナーゼ（CDK）の調節因子として機能する。サイクリンはそれぞれ異なる発現と分解のパターンを示し、有糸分裂の各イベントの時間的調整に寄与している。サイクリンT1はCDK9と強固に結合し、転写伸長因子P-TEFbの主要な構成要素であることが知られている。このP-TEFb複合体はHIV-1のTat（英語版）タンパク質と相互作用してそのコファクターとして機能し、ウイルス転写の完全な活性化に必要かつ十分な因子であることが示されている。このCDK複合体はRNAポリメラーゼIIの最大サブユニットのC末端ドメイン（CTD）のリン酸化と調節に関与していることも知られている^[7]。

相互作用

サイクリンT1は次に挙げる因子と相互作用することが示されている。

AHR^[8]
CDK9^[6]^[9]^[10]^[11]^[12]^[13]^[14]^[15]^[16]
GRN（英語版）^[10]
HEXIM1（英語版）^[9]
Myc^[17]
NUFIP1（英語版）^[11]
PML^[18]

出典

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129315 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000011960 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA”. Cell 92 (4): 451–62. (March 1998). doi:10.1016/S0092-8674(00)80939-3. PMID 9491887.
^ ^a ^b “Identification of multiple cyclin subunits of human P-TEFb”. Genes Dev. 12 (5): 755–62. (April 1998). doi:10.1101/gad.12.5.755. PMC 316581. PMID 9499409.
^ “Entrez Gene: CCNT1 cyclin T1”. 2023年9月16日閲覧。
^ “Interactions between the aryl hydrocarbon receptor and P-TEFb. Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at cyp1a1 promoter”. J. Biol. Chem. 278 (45): 44041–8. (November 2003). doi:10.1074/jbc.M306443200. PMID 12917420.
^ ^a ^b “MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner”. Mol. Cell. Biol. 23 (14): 4859–69. (July 2003). doi:10.1128/mcb.23.14.4859-4869.2003. PMC 162212. PMID 12832472.
^ ^a ^b “The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription”. Mol. Cell. Biol. 23 (5): 1688–702. (March 2003). doi:10.1128/mcb.23.5.1688-1702.2003. PMC 151712. PMID 12588988.
^ ^a ^b “BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II”. Oncogene 23 (31): 5316–29. (July 2004). doi:10.1038/sj.onc.1207684. PMID 15107825.
^ “The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription”. Mol. Cell. Biol. 23 (18): 6373–84. (September 2003). doi:10.1128/mcb.23.18.6373-6384.2003. PMC 193714. PMID 12944466.
^ “Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome”. Mol. Cell. Biol. 21 (23): 7956–70. (December 2001). doi:10.1128/MCB.21.23.7956-7970.2001. PMC 99964. PMID 11689688.
^ “Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation”. Oncogene 19 (3): 373–9. (January 2000). doi:10.1038/sj.onc.1203305. PMID 10656684.
^ “Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription”. J. Biol. Chem. 274 (49): 34527–30. (December 1999). doi:10.1074/jbc.274.49.34527. PMID 10574912.
^ “CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA”. Mol. Cell. Biol. 20 (18): 6958–69. (September 2000). doi:10.1128/mcb.20.18.6958-6969.2000. PMC 88771. PMID 10958691.
^ “c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis”. Oncogene 22 (36): 5707–11. (August 2003). doi:10.1038/sj.onc.1206800. PMID 12944920.
^ “Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein”. EMBO J. 22 (9): 2156–66. (May 2003). doi:10.1093/emboj/cdg205. PMC 156077. PMID 12727882.

関連文献

“Tat, Tat-associated kinase, and transcription”. J. Biomed. Sci. 5 (1): 24–7. (1998). doi:10.1007/BF02253352. PMID 9570510.
“Transcriptional control: Tat cofactors and transcriptional elongation”. Curr. Biol. 8 (13): R447-9. (1998). doi:10.1016/S0960-9822(98)70289-1. PMID 9651670.
“Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression”. J. Cell. Biochem. 75 (3): 357–68. (1999). doi:10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K. PMID 10536359.
“The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes”. J. Leukoc. Biol. 68 (3): 311–7. (2000). doi:10.1189/jlb.68.3.311. PMID 10985245.
“Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator”. IUBMB Life 51 (3): 175–81. (2001). doi:10.1080/152165401753544241. PMID 11547919.
“Multiple effects of HIV-1 trans-activator protein on the pathogenesis of HIV-1 infection”. Eur. J. Clin. Invest. 34 (1): 57–66. (2004). doi:10.1111/j.1365-2362.2004.01282.x. PMID 14984439.
“Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophages”. Curr. HIV Res. 1 (4): 395–404. (2003). doi:10.2174/1570162033485159. PMID 15049426.
“Multiple actions of the human immunodeficiency virus type-1 Tat protein on microglial cell functions”. Neurochem. Res. 29 (5): 965–78. (2004). doi:10.1023/B:NERE.0000021241.90133.89. PMID 15139295.
“Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1”. DNA Cell Biol. 23 (4): 193–205. (2004). doi:10.1089/104454904773819789. PMID 15142377. https://zenodo.org/record/1235217.
“HIV-1 infection and regulation of Tat function in macrophages”. Int. J. Biochem. Cell Biol. 36 (9): 1767–75. (2004). doi:10.1016/j.biocel.2004.02.018. PMID 15183343.
“A review of HIV-1 Tat protein biological effects”. Cell Biochem. Funct. 23 (4): 223–7. (2005). doi:10.1002/cbf.1147. PMID 15473004.
“HIV-1 TAR RNA: the target of molecular interactions between the virus and its host”. Curr. HIV Res. 3 (1): 61–71. (2005). doi:10.2174/1570162052772924. PMID 15638724.
“HIV-1 tat protein and cell proliferation and survival: a brief review”. New Microbiol. 28 (2): 95–109. (2005). PMID 16035254.
“The multiple functions of HIV-1 Tat: proliferation versus apoptosis”. Front. Biosci. 11: 708–717. (2006). doi:10.2741/1829. PMID 16146763. オリジナルの2019-02-24時点におけるアーカイブ。.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129315 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000011960 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[pmid9491887-5] “A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA”. Cell 92 (4): 451–62. (March 1998). doi:10.1016/S0092-8674(00)80939-3. PMID 9491887.

[pmid9499409-6] “Identification of multiple cyclin subunits of human P-TEFb”. Genes Dev. 12 (5): 755–62. (April 1998). doi:10.1101/gad.12.5.755. PMC 316581. PMID 9499409.

[7] “Entrez Gene: CCNT1 cyclin T1”. 2023年9月16日閲覧。

[pmid12917420-8] “Interactions between the aryl hydrocarbon receptor and P-TEFb. Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at cyp1a1 promoter”. J. Biol. Chem. 278 (45): 44041–8. (November 2003). doi:10.1074/jbc.M306443200. PMID 12917420.

[pmid12832472-9] “MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner”. Mol. Cell. Biol. 23 (14): 4859–69. (July 2003). doi:10.1128/mcb.23.14.4859-4869.2003. PMC 162212. PMID 12832472.

[pmid12588988-10] “The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription”. Mol. Cell. Biol. 23 (5): 1688–702. (March 2003). doi:10.1128/mcb.23.5.1688-1702.2003. PMC 151712. PMID 12588988.

[pmid15107825-11] “BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II”. Oncogene 23 (31): 5316–29. (July 2004). doi:10.1038/sj.onc.1207684. PMID 15107825.

[pmid12944466-12] “The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription”. Mol. Cell. Biol. 23 (18): 6373–84. (September 2003). doi:10.1128/mcb.23.18.6373-6384.2003. PMC 193714. PMID 12944466.

[pmid11689688-13] “Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome”. Mol. Cell. Biol. 21 (23): 7956–70. (December 2001). doi:10.1128/MCB.21.23.7956-7970.2001. PMC 99964. PMID 11689688.

[pmid10656684-14] “Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation”. Oncogene 19 (3): 373–9. (January 2000). doi:10.1038/sj.onc.1203305. PMID 10656684.

[pmid10574912-15] “Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription”. J. Biol. Chem. 274 (49): 34527–30. (December 1999). doi:10.1074/jbc.274.49.34527. PMID 10574912.

[pmid10958691-16] “CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA”. Mol. Cell. Biol. 20 (18): 6958–69. (September 2000). doi:10.1128/mcb.20.18.6958-6969.2000. PMC 88771. PMID 10958691.

[pmid12944920-17] “c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis”. Oncogene 22 (36): 5707–11. (August 2003). doi:10.1038/sj.onc.1206800. PMID 12944920.

[pmid12727882-18] “Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein”. EMBO J. 22 (9): 2156–66. (May 2003). doi:10.1093/emboj/cdg205. PMC 156077. PMID 12727882.

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サイクリンT1とは？ わかりやすく解説