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遺伝性非ポリポーシス大腸癌
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出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2022/06/15 15:35 UTC 版)
遺伝性非ポリポーシス大腸癌(いでんせい・ひポリポーシス・だいちょうがん、英: Hereditary nonpolyposis colorectal cancer、HNPCC )とは常染色体優性の遺伝的素因による大腸癌である[1]。子宮癌、卵巣癌、胃癌、小腸腫瘍、胆嚢癌、尿管癌、脳腫瘍、皮膚癌など、他臓器における発癌もしばしばみられる。これらの発癌リスクの上昇はDNAミスマッチ修復酵素の変異による。
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- ^ Vasen HF, et al. Guideline fo the clinical management of Lynch syndrome(hereditary non-polyposis cancer). J Med Gnet 2007;44:353-62
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- ^ http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim
- ^ Fishel R, Lescoe M, Rao M, Copeland N, Jenkins N, Garber J, Kane M, Kolodner R (1993). “The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer”. Cell 75 (5): 1027–38. doi:10.1016/0092-8674(93)90546-3. PMID 8252616.
- ^ Papadopoulos N, Nicolaides N, Wei Y, Ruben S, Carter K, Rosen C, Haseltine W, Fleischmann R, Fraser C, Adams M (1994). “Mutation of a mutL homolog in hereditary colon cancer”. Science 263 (5153): 1625–9. doi:10.1126/science.8128251. PMID 8128251.
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- ^ http://grj.umin.jp/grj/hnpcc.htm
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- ^ Burn J, Bishop DT, Mecklin JP, et al. (December 2008). “Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome”. N. Engl. J. Med. 359 (24): 2567–78. doi:10.1056/NEJMoa0801297. PMID 19073976 .
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- ^ Jasperson KW et al. Hereditary and familial colon cancer. Gastroenterology 2010;138(6):2044-58.
- ^ Cannard G, et al. Screening for Lynch syndrome in colorectal cancer: are we doing enough? Ann Surg Oncol. 2012;19(3):809-16.
- ^ Le DT, et al. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N Engl J Med. 2015 Jun 25;372(26):2509-20. doi: 10.1056/NEJMoa1500596. Epub 2015 May 30.
- ^ http://www.ono.co.jp/jpnw/PDF/n17_0803.pdf
- ^ 野水整、権田憲士他「わが国における遺伝性非ポリポーシス大腸癌の臨床的検討 -文献的考察-」『家族性腫瘍』第4巻第1号、2004年、 p.p.42-48、 ISSN 1346-1052。
- ^ 冨田尚裕 (2008年6月11日). “遺伝性非ポリポーシス大腸癌”. MyMed医療電子教科書. 2010年8月21日閲覧。
- ^ The Abramson Cancer Center of the University of Pennsylvania (2002年1月6日). “OncoLink eNews: On the Forefront of Colorectal Cancer, Winter 2002”. OncoLink. 2010年8月21日閲覧。
- 1 遺伝性非ポリポーシス大腸癌とは
- 2 遺伝性非ポリポーシス大腸癌の概要
- 3 スクリーニング検査
- 4 疫学
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