長鎖散在反復配列
(Long interspersed nuclear element から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/09/18 09:28 UTC 版)
長鎖散在反復配列（ちょうささんざいはんぷくはいれつ、英: long interspersed nuclear element, LINE）とは、非LTR型レトロトランスポゾンの一群である。多くの真核生物のゲノムに広く見られ[1][2]、ヒトゲノムでは全体のおよそ21.1%を占める[3][4][5]。それぞれの長さはおおよそ7000塩基対程度である。mRNAへ転写されたのち、逆転写酵素活性を持つタンパク質へと翻訳される。この逆転写酵素によりLINE RNAからコピーされたDNAのゲノム上における新しいサイトへの組み込みが可能となる。
- ^ “SINEs and LINEs: highly repeated short and long interspersed sequences in mammalian genomes”. Cell 28 (3): 433–4. (March 1982). doi:10.1016/0092-8674(82)90194-5. PMID 6280868.
- ^ Jurka, J. (1998). “Repeats in genomic DNA: Mining and meaning”. Current Opinion in Structural Biology 8 (3): 333–337. doi:10.1016/S0959-440X(98)80067-5. PMID 9666329.
- ^ “Genome sequence, comparative analysis and haplotype structure of the domestic dog”. Nature 438 (7069): 803–19. (December 2005). Bibcode: 2005Natur.438..803L. doi:10.1038/nature04338. PMID 16341006.
- ^ Unique functions of repetitive transcriptomes. International Review of Cell and Molecular Biology. 285. (2010-01-01). pp. 115–88. doi:10.1016/B978-0-12-381047-2.00003-7. ISBN 9780123810472. PMID 21035099
- ^ a b c “Initial sequencing and analysis of the human genome”. Nature 409 (6822): 860–921. (February 2001). Bibcode: 2001Natur.409..860L. doi:10.1038/35057062. PMID 11237011.
- ^ “Reading between the LINEs: human genomic variation induced by LINE-1 retrotransposition”. Genome Research 10 (10): 1496–508. (October 2000). doi:10.1101/gr.149400. PMC 310943. PMID 11042149.
- ^ “A family of long reiterated DNA sequences, one copy of which is next to the human beta globin gene”. Nucleic Acids Research 8 (24): 6113–28. (December 1980). doi:10.1093/nar/8.24.6113. PMC 328076. PMID 6258162.
- ^ a b “Simple and fast classification of non-LTR retrotransposons based on phylogeny of their RT domain protein sequences”. Gene 448 (2): 207–13. (December 2009). doi:10.1016/j.gene.2009.07.019. PMC 2829327. PMID 19651192.
- ^ “Evolutionary dynamics and evolutionary history in the RTE clade of non-LTR retrotransposons”. Molecular Biology and Evolution 18 (10): 1849–63. (October 2001). doi:10.1093/oxfordjournals.molbev.a003727. PMID 11557792.
- ^ “BNR - a LINE family from Beta vulgaris - contains a RRM domain in open reading frame 1 and defines a L1 sub-clade present in diverse plant genomes”. The Plant Journal 59 (6): 872–82. (September 2009). doi:10.1111/j.1365-313x.2009.03923.x. PMID 19473321.
- ^ “Two-step regulation and continuous retrotransposition of the rice LINE-type retrotransposon Karma”. The Plant Cell 15 (8): 1934–44. (August 2003). doi:10.1105/tpc.011809. PMC 167180. PMID 12897263.
- ^ “Profiling of extensively diversified plant LINEs reveals distinct plant-specific subclades”. The Plant Journal 79 (3): 385–97. (August 2014). doi:10.1111/tpj.12565. PMID 24862340.
- ^ “Acquisition of an Archaea-like ribonuclease H domain by plant L1 retrotransposons supports modular evolution”. Proceedings of the National Academy of Sciences of the United States of America 110 (50): 20140–5. (December 2013). Bibcode: 2013PNAS..11020140S. doi:10.1073/pnas.1310958110. PMC 3864347. PMID 24277848.
- ^ “Non-LTR retrotransposons in fungi”. Functional & Integrative Genomics 9 (1): 27–42. (February 2009). doi:10.1007/s10142-008-0093-8. PMID 18677522.
- ^ “The age and evolution of non-LTR retrotransposable elements”. Molecular Biology and Evolution 16 (6): 793–805. (June 1999). doi:10.1093/oxfordjournals.molbev.a026164. PMID 10368957.
- ^ “Genome analysis of the platypus reveals unique signatures of evolution”. Nature 453 (7192): 175–83. (May 2008). Bibcode: 2008Natur.453..175W. doi:10.1038/nature06936. PMC 2803040. PMID 18464734.
- ^ “The genome sizes of megabats (Chiroptera: Pteropodidae) are remarkably constrained”. Biology Letters 5 (3): 347–51. (June 2009). doi:10.1098/rsbl.2009.0016. PMC 2679926. PMID 19324635.
- ^ Kapitonov, Vladimir V.; Pavlicek, Adam; Jurka, Jerzy (2006-01-01). Anthology of Human Repetitive DNA. Wiley-VCH Verlag GmbH & Co. KGaA. doi:10.1002/3527600906.mcb.200300166. ISBN 9783527600908
- ^ “Evolutionary dynamics in a novel L2 clade of non-LTR retrotransposons in Deuterostomia”. Molecular Biology and Evolution 18 (12): 2213–24. (December 2001). doi:10.1093/oxfordjournals.molbev.a003768. PMID 11719571.
- ^ Malik, HS; Eickbush, TH (September 1998). “The RTE class of non-LTR retrotransposons is widely distributed in animals and is the origin of many SINEs.”. Molecular Biology and Evolution 15 (9): 1123–34. doi:10.1093/oxfordjournals.molbev.a026020. PMID 9729877.
- ^ “Sequencing, identification and mapping of primed L1 elements (SIMPLE) reveals significant variation in full length L1 elements between individuals”. BMC Genomics 16 (220): 220. (March 2015). doi:10.1186/s12864-015-1374-y. PMC 4381410. PMID 25887476.
- ^ “Increased l1 retrotransposition in the neuronal genome in schizophrenia”. Neuron 81 (2): 306–13. (January 2014). doi:10.1016/j.neuron.2013.10.053. PMID 24389010.
- ^ “L1 integration in a transgenic mouse model”. Genome Research 16 (2): 240–50. (February 2006). doi:10.1101/gr.4571606. PMC 1361720. PMID 16365384.
- ^ “Sequence patterns indicate an enzymatic involvement in integration of mammalian retroposons”. Proceedings of the National Academy of Sciences of the United States of America 94 (5): 1872–7. (March 1997). Bibcode: 1997PNAS...94.1872J. doi:10.1073/pnas.94.5.1872. PMC 20010. PMID 9050872.
- ^ “Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition”. Cell 72 (4): 595–605. (February 1993). doi:10.1016/0092-8674(93)90078-5. PMID 7679954.
- ^ “L1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells”. Nature Structural & Molecular Biology 13 (9): 763–71. (September 2006). doi:10.1038/nsmb1141. PMID 16936727.
- ^ “Loss of Karma transposon methylation underlies the mantled somaclonal variant of oil palm”. Nature 525 (7570): 533–7. (September 2015). Bibcode: 2015Natur.525..533O. doi:10.1038/nature15365. PMC 4857894. PMID 26352475.
- ^ “Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity”. Nucleic Acids Research 42 (1): 396–416. (January 2014). doi:10.1093/nar/gkt898. PMC 3874205. PMID 24101588.
- ^ “Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man”. Nature 332 (6160): 164–6. (March 1988). Bibcode: 1988Natur.332..164K. doi:10.1038/332164a0. PMID 2831458.
- ^ “Mobile elements in the human genome: implications for disease”. Genome Medicine 4 (2): 12. (February 2012). doi:10.1186/gm311. PMC 3392758. PMID 22364178.
- ^ “L1 retrotransposons, cancer stem cells and oncogenesis”. The FEBS Journal 281 (1): 63–73. (January 2014). doi:10.1111/febs.12601. PMC 4160015. PMID 24286172.
- ^ “Long interspersed nuclear element-1 hypomethylation in cancer: biology and clinical applications”. Clinical Epigenetics 2 (2): 315–30. (August 2011). doi:10.1007/s13148-011-0032-8. PMC 3365388. PMID 22704344.
- ^ “LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability”. PLOS ONE 2 (5): e399. (May 2007). Bibcode: 2007PLoSO...2..399E. doi:10.1371/journal.pone.0000399. PMC 1851990. PMID 17476321.
- ^ “Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer”. PLOS Genetics 6 (4): e1000917. (April 2010). doi:10.1371/journal.pgen.1000917. PMC 2858672. PMID 20421991.
- ^ “A LINE-1-encoded reverse transcriptase-dependent regulatory mechanism is active in embryogenesis and tumorigenesis”. Annals of the New York Academy of Sciences 1341 (1): 164–71. (April 2015). Bibcode: 2015NYASA1341..164S. doi:10.1111/nyas.12637. PMID 25586649.
- ^ “Regulation of L1 expression and retrotransposition by melatonin and its receptor: implications for cancer risk associated with light exposure at night”. Nucleic Acids Research 42 (12): 7694–707. (July 2014). doi:10.1093/nar/gku503. PMC 4081101. PMID 24914052.
[続きの解説]
「長鎖散在反復配列」の続きの解説一覧
- 1 長鎖散在反復配列とは
- 2 長鎖散在反復配列の概要
- 3 伝播
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