辻彰
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/06/28 02:04 UTC 版)
辻 彰（つじ あきら、1942年8月6日 - 2016年5月18日）は、日本の薬剤学者、金沢大学大学院自然科学研究科薬学系名誉教授。一般社団法人医薬品開発支援機構代表理事。細胞膜における物質輸送担体（トランスポーター）研究の第一人者として国際的に高い評価を得ている。
- ^ 博士論文書誌データベース
- ^ Tsuji A, Nakashima E, Kagami I, Honjo N, and Yamana T (1977). “Effect of dose-concentration on the absorption of amoxicillin and ampicillin from the rat intestine”. J. Pharm. Pharmcol. 29: 707-708. doi:10.1111/j.2042-7158.1977.tb11443.x. PMID 22611.
- ^ Tsuji A, Hirooka H, Tamai I, and Terasaki T (1986). “Evidence for a carrier-mediated transport system in the small intestine available for FK089, a new cephalosporin antibiotic without an amino group”. J. Antibiot. 39: 1592-1597. doi:10.7164/antibiotics.39.1592. PMID 3689491.
- ^ Sai Y, Tamai I, Sumikawa H, Hayashi K, Nakanishi T, Amano O, Numata M, Iseki S, and A.Tsuji (1996). “Immunolocalization and pharmacological relevance of oligopeptide transporter PepT1 in intestinal absorption of β-lactam antibiotics”. FEBS Lett. 392: 25-29. doi:10.1016/0014-5793(96)00778-8. PMID 8769308.
- ^ Tsuji A, Takanaga H, Tamai I, and Terasaki T (1994). “Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism”. Pharm. Res. 11: 30-37. doi:10.1023/A:1018933324914. PMID 8140053.
- ^ Levi VA (1980). “Relationships of octanol/water partition coefficient and molecular weight to rat brain capillary permeability”. J. Med. Chem. 23: 682-684. doi:10.1021/jm00180a022. PMID 7392035.
- ^ Tsuji A, Terasaki T, Takabatake Y, Tenda Y, Tamai I, Yamashita T, Moritani S, Tsuruno T and Yamashita J (1992). “P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells”. Life Sci. 51: 1427-1437. doi:10.1016/0024-3205(92)90537-Y. PMID 1357522.
- ^ Sakata A, Tamai I, Kawazu K, Deguchi Y, Ohnishi T, Sahei A, and Tsuji A (1994). “In vivo evidence for ATP-dependent P-glycoprotein mediated transport of cyclosporin A at the blood-brain barrier.”. Biochem. Pharmacol. 48: 1989-1992. doi:10.1016/0006-2952(94)90601-7. PMID 7986214.
- ^ Schinkel AH, Smit JJM, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CAAM, van der Valk MA, Robanus-Maandag EC, te Riele HPJ, Berns A, and Borst JMP (1994). “Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs”. Cell 77: 491-502. doi:10.1016/0092-8674(94)90212-7. PMID 7910522.
- ^ 大槻純男, 堀里子, 寺崎哲也「血液脳関門の薬物透過と排出の分子機構」『日薬理誌』第122巻、2003年、55-64頁、doi:10.1254/fpj.122.55。
- ^ Sun H, Dai H, Shaik N, and Elmquist WE (2003). “Drug efflux transporters in the CNS”. Adv. Drug Delivery Rev. 55: 83-105. doi:10.1016/S0169-409X(02)00172-2. PMID 12535575.
- ^ Tamai I, Nakanishi T, Kobayashi D, China K, Kosugi Y, Nezu J, Sai Y, and Tsuji A (2004). “Involvment of OCTN1 (SLC22A4) in pH-dependent transport of organic cations”. Mol. Pharm. 1: 57-66. doi:10.1021/mp0340082. PMID 15832501.
- ^ Tamai I, Ohashi R, Nezu JI, Yabuuchi H, Oku A, Shimane M, Sai Y, and Tsuji A (2000). “Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2”. J. Biol. Chem. 273: 20378-20382. doi:10.1074/jbc.273.32.20378. PMID 9685390.
- ^ Nezu J, Tamai I, Oku A, Ohashi R, Yabuuchi H, Hashimoto N, Nikaido H, Sai Y, Koizumi A, Shoji Y, Takada G, Matsuishi T, Yoshino M, Kato H, Ohura T, Tsujimoto G, Hayakawa J, Shimane M, and Tsuji A (1999). “Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter”. Nat. Genet. 21: 91-94. doi:10.1038/5030. PMID 9916797.
- ^ American Pharmacists Association (ed) (2011). “Akira Tsuji Dedicated Issue”. J. Pharm. Sci. 100 (9): 3541-4043.
- ^ Sugiura T, Kato Y, Kubo Y, and Tsuji A (2006). “Mutation in an Adaptor Protein PDZK1 Affects Transport Activity of Organic Cation Transporter OCTNs and Oligopeptide Transporter PEPT2”. Drug Metab. Pharmacokinet. 21: 375-383. doi:10.2133/dmpk.21.375. PMID 17072090.
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