アデノ随伴ウイルスとは？ わかりやすく解説

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アデノ随伴ウイルス

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/02/27 14:55 UTC 版)

アデノ随伴ウイルス(英: Adeno-associated virus:AAV)とはヒトや霊長目の動物に感染する小型(20nm程度)の、パルボウイルス科ディペンドウイルス属に分類されるヘルパー依存型のエンベロープを持たないウイルスである。非常に弱い免疫反応しか引き起こさず、病原性は現在の所確認されていない。分裂期にある細胞にもそうでない細胞にもゲノムを送り込むことができ、宿主細胞にゲノムを送り込まずとも染色体外で生存することができる [1]。そのような特色があるためにベクターウイルスを用いた遺伝子治療やヒトの疾患モデル細胞の作成などに用いられる[2]。1型から5型まである。


引用文献
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  78. ^ Duan D, Sharma P, Yang J, et al. (November 1, 1998). “Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue”. Journal of Virology 72 (11): 8568–77. PMC 110267. PMID 9765395. http://jvi.asm.org/cgi/pmidlookup?view=long&pmid=9765395. 

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