HP1
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/12/20 06:53 UTC 版)
HP1（heterochromatin protein 1）ファミリーは高度に保存されたタンパク質から構成され、細胞核で重要な機能を果たす。CBX（chromobox homolog）ファミリーとも呼ばれる。その機能は、ヘテロクロマチン形成による遺伝子発現抑制、転写活性化、セントロメアへの接着複合体の結合の調節、核周縁部への遺伝子の隔離、転写の一時停止、ヘテロクロマチンの完全性の維持、1ヌクレオソームレベルでの遺伝子の抑制、ユークロマチンのヘテロクロマチン化による遺伝子抑制、DNA修復など多岐にわたる。HP1タンパク質はヘテロクロマチンのパッケージングの基本的単位であり、ほぼすべての真核生物の染色体でセントロメアとテロメアに豊富に存在する。特筆すべき例外は出芽酵母であり、酵母特異的なサイレンシング複合体であるSIR（silent information regulatory）タンパク質が同様の機能を果たしている。HP1ファミリーのメンバーはN末端のクロモドメインとC末端のクロモシャドウドメインがヒンジ領域で隔てられていることで特徴づけられる。HP1はユークロマチン領域にも存在し、その結合は遺伝子の抑制と相関している。HP1は1986年にTharappel C. JamesとSarah Elginによって、キイロショウジョウバエDrosophila melanogasterで斑入り位置効果（position-effect variegation）と呼ばれる現象に関する因子として発見された[1][2]。
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- ^ “Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster”. Proceedings of the National Academy of Sciences of the United States of America 87 (24): 9923–7. (December 1990). Bibcode: 1990PNAS...87.9923E. doi:10.1073/pnas.87.24.9923. PMC 55286. PMID 2124708.
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- ^ “Arabidopsis TERMINAL FLOWER 2 gene encodes a heterochromatin protein 1 homolog and represses both FLOWERING LOCUS T to regulate flowering time and several floral homeotic genes”. Plant & Cell Physiology 44 (6): 555–64. (June 2003). doi:10.1093/pcp/pcg091. PMID 12826620.
- ^ “Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31”. The EMBO Journal 18 (7): 1923–38. (April 1999). doi:10.1093/emboj/18.7.1923. PMC 1171278. PMID 10202156.
- ^ “A mammalian homologue of Drosophila heterochromatin protein 1 (HP1) is a component of constitutive heterochromatin”. Cytogenetics and Cell Genetics 66 (2): 99–103. (1994). doi:10.1159/000133676. PMID 8287692.
- ^ “Human heterochromatin protein 1 isoforms HP1(Hsalpha) and HP1(Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiation”. Molecular and Cellular Biology 23 (22): 8363–76. (November 2003). doi:10.1128/MCB.23.22.8363-8376.2003. PMC 262350. PMID 14585993.
- ^ “Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context-dependent manner”. Nature Genetics 23 (4): 457–61. (December 1999). doi:10.1038/70579. PMID 10581035.
- ^ “Heterochromatin protein 1 (HP1): interactions with itself and chromatin components”. Biophysical Reviews 12 (2): 387–400. (April 2020). doi:10.1007/s12551-020-00663-y. PMC 7242596. PMID 32144738.
- ^ “Human origin recognition complex is essential for HP1 binding to chromatin and heterochromatin organization”. Proceedings of the National Academy of Sciences of the United States of America 107 (34): 15093–8. (August 2010). doi:10.1073/pnas.1009945107. PMC 2930523. PMID 20689044.
- ^ “MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation”. Nucleic Acids Research 35 (16): 5402–8. (August 2007). doi:10.1093/nar/gkm599. PMC 2018631. PMID 17698499.
- ^ “In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation”. Molecular and Cellular Biology 25 (11): 4552–64. (June 2005). doi:10.1128/mcb.25.11.4552-4564.2005. PMID 15899859.
- ^ “Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins”. Nature 410 (6824): 116–20. (March 2001). doi:10.1038/35065132. PMID 11242053.
- ^ “Affinity, stoichiometry and cooperativity of heterochromatin protein 1 (HP1) binding to nucleosomal arrays”. Journal of Physics. Condensed Matter 27 (6): 064110. (February 2015). arXiv:1408.6184. Bibcode: 2015JPCM...27f4110T. doi:10.1088/0953-8984/27/6/064110. PMID 25563825.
- ^ “Dynamics of inherently bounded histone modification domains”. Proceedings of the National Academy of Sciences of the United States of America 109 (33): 13296–301. (August 2012). Bibcode: 2012PNAS..10913296H. doi:10.1073/pnas.1211172109. PMC 3421184. PMID 22847427.
- ^ “Dynamics and memory of heterochromatin in living cells”. Cell 149 (7): 1447–60. (June 2012). doi:10.1016/j.cell.2012.03.052. PMC 3422694. PMID 22704655.
- ^ a b c “HP1 is involved in regulating the global impact of DNA methylation on alternative splicing”. Cell Reports 10 (7): 1122–34. (February 2015). doi:10.1016/j.celrep.2015.01.038. PMID 25704815.
- ^ a b “Regulation of fibronectin EDA exon alternative splicing: possible role of RNA secondary structure for enhancer display”. Molecular and Cellular Biology 19 (4): 2657–71. (April 1999). doi:10.1128/MCB.19.4.2657. PMC 84059. PMID 10082532.
- ^ “The emerging role of HP1 in the DNA damage response”. Molecular and Cellular Biology 29 (24): 6335–40. (December 2009). doi:10.1128/MCB.01048-09. PMC 2786877. PMID 19805510.
- ^ a b “Function of heterochromatin protein 1 during DNA repair”. Protoplasma 254 (3): 1233–1240. (May 2017). doi:10.1007/s00709-017-1090-3. PMID 28236007.
- ^ “Heterochromatin protein 1 is recruited to various types of DNA damage”. The Journal of Cell Biology 185 (4): 577–86. (May 2009). doi:10.1083/jcb.200810035. PMC 2711568. PMID 19451271.
[続きの解説]
「HP1」の続きの解説一覧
- 1 HP1とは
- 2 HP1の概要
- 3 DNA修復における役割
- HP1のページへのリンク
