ARNTとは？わかりやすく解説

ARNT
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	4PKY, 1X0O, 2A24, 2B02, 2HV1, 2K7S, 3F1N, 3F1O, 3F1P, 3H7W, 3H82, 4EQ1, 4GHI, 4GS9, 4H6J, 4LPZ, 4XT2
識別子
記号	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2, aryl hydrocarbon receptor nuclear translocator, Aryl hydrocarbon receptor nuclear translocator
外部ID	OMIM: 126110 MGI: 88071 HomoloGene: 1261 GeneCards: ARNT
遺伝子の位置 (ヒト)
染色体	1番染色体 (ヒト)
終点	150,876,708 bp
遺伝子の位置 (マウス)
染色体	3番染色体 (マウス)
終点	95,404,551 bp
RNA発現パターン
	; ; ; ;
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• sequence-specific DNA binding; • DNA結合; • protein dimerization activity; • DNA-binding transcription factor activity; • transcription coactivator activity; • aryl hydrocarbon receptor binding; • 転写因子結合; • 血漿タンパク結合; • protein heterodimerization activity; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • DNA-binding transcription factor activity, RNA polymerase II-specific; • protein homodimerization activity; • sequence-specific double-stranded DNA binding; • nuclear receptor activity;
細胞の構成要素	• 細胞質; • transcription regulator complex; • 核質; • RNA polymerase II transcription regulator complex; • 細胞核; • 核内構造体;
生物学的プロセス	• positive regulation of vascular endothelial growth factor receptor signaling pathway; • 細胞分化; • response to hypoxia; • regulation of transcription, DNA-templated; • positive regulation of endothelial cell proliferation; • regulation of transcription from RNA polymerase II promoter in response to oxidative stress; • positive regulation of erythrocyte differentiation; • embryonic placenta development; • mRNA transcription by RNA polymerase II; • positive regulation of protein sumoylation; • transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • intracellular receptor signaling pathway; • regulation of transcription from RNA polymerase II promoter in response to hypoxia; • positive regulation of vascular endothelial growth factor production; • positive regulation of glycolytic process; • positive regulation of transcription by RNA polymerase II; • positive regulation of hormone biosynthetic process; • 生体異物の代謝プロセス;
	出典:Amigo / QuickGO
オルソログ
	405
	11863
	ENSG00000143437
	ENSMUSG00000015522
	P27540
	P53762
NM_001197325; NM_001286035; NM_001286036; NM_001668; NM_178426;
	NM_178427; NM_001350224; NM_001350225; NM_001350226
	NM_001037737; NM_009709
NP_001184254; NP_001272964; NP_001272965; NP_001659; NP_848514;
	NP_001337153; NP_001337154; NP_001337155
	NP_001032826; NP_033839
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

芳香族炭化水素受容体核内輸送体（ARNT: aryl hydrocarbon receptor nuclear translocator）は、リガンド結合型芳香族炭化水素受容体（AhR）と複合体を形成するタンパク質であり、AhRが受容体として機能するために必要である。また、低酸素誘導因子1（HIF1）のベータサブユニットとしても知られている。TEL-ARNT融合タンパク質の発現をもたらす遺伝子座のt(1; 12)(q21; p13)転座は、急性骨髄芽球性白血病と関連している。この遺伝子について、異なるアイソフォームをコードする3つのスプライスバリアントが報告されている。

AhRは、生体異物代謝に関与するいくつかの酵素の誘導に関与している。リガンドを含まない、細胞質ゾル型のAhRは、熱ショックタンパク質90（Hsp90）と複合体を形成する。ダイオキシンと多環芳香族炭化水素を含むリガンドの結合は、リガンド結合サブユニットの核への転座をもたらす^[5]。生体異物代謝に関与する酵素の誘導は、これら酵素の遺伝子のプロモーター内の生体異物応答エレメントへのリガンド結合型AhRの結合を介して発生する。

相互作用分子

ARNTは、以下の生体分子と相互作用する。

芳香族炭化水素受容体相互作用タンパク質（AIP）^[6]^[7]
芳香族炭化水素受容体（AHR）^[8]^[9]^[10]^[11]
内皮PASドメイン含有タンパク質（EPAS1）^[12]
低酸素誘導因子1A（HIF1A）^[12]^[13]
核内受容体コアクチベーター2（NCOA2）^[14]
SIM1^[13]^[15]
SIM2^[13]^[15]^[16]^[17]

脚注

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143437 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015522 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ Duncan Hughes, Joseph B. Guttenplan, Craig B. Marcus, Kotha Subbaramaiah and Andrew J. Dannenberg (5 November 2008). “Heat Shock Protein 90 Inhibitors Suppress Aryl Hydrocarbon Receptor-Mediated Activation of CYP1A1 and CYP1B1 Transcription and DNA Adduct Formation”. Cancer Prevention Research 1 (6): 485–493. doi:10.1158/1940-6207.CAPR-08-0149. PMC 2680610. PMID 19138996.
^ Lucy A. Carver, Christopher A. Bradfield (25 April 1997). “Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo”. Journal of Biological Chemistry 272 (17): 11452–6. doi:10.1074/jbc.272.17.11452. PMID 9111057.
^ Arunas Kazlauskas, Sara Sundström, Lorenz Poellinger, and Ingemar Pongratz (April 2001). “The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor”. Molecular and Cellular Biology 21 (7): 2594–607. doi:10.1128/MCB.21.7.2594-2607.2001. PMC 86890. PMID 11259606.
^ M.C. Lindebro, L. Poellinger, M.L. Whitelaw (01 July 1995). “Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex”. EMBO Journal 14 (14): 3528–39. doi:10.1002/j.1460-2075.1995.tb07359.x. PMC 394421. PMID 7628454.
^ M Whitelaw, I Pongratz, A Wilhelmsson, J A Gustafsson, L Poellinger (April 1993). “Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor”. Molecular and Cellular Biology 13 (4): 2504–14. doi:10.1128/MCB.13.4.2504. PMC 359572. PMID 8384309.
^ Yumi Yamaguchi, M. Tien Kuo (12 October 1995). “Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast two-hybrid system”. Biochemical Pharmacology 50 (8): 1295–302. doi:10.1016/0006-2952(95)02016-6. PMID 7488247.
^ Junsei Mimura, Masatsugu Ema, Kazuhiro Sogawa, and Yoshiaki Fujii-Kuriyama (01 January 1999). “Identification of a novel mechanism of regulation of Ah (dioxin) receptor function”. Genes & Development 13 (1): 20–5. doi:10.1101/gad.13.1.20. PMC 316371. PMID 9887096.
^ ^a ^b John B. Hogenesch, William K. Chan, Victoria H. Jackiw, R. Clark Brown, Yi-Zhong Gu, Marilyn Pray-Grant, Gary H. Perdew, Christopher A. Bradfield (28 March 1997). “Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway”. Journal of Biological Chemistry 272 (13): 8581–93. doi:10.1074/jbc.272.13.8581. PMID 9079689.
^ ^a ^b ^c Susan L. Woods, Murray L. Whitelaw (22 March 2002). “Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors”. Journal of Biological Chemistry 277 (12): 10236–43. doi:10.1074/jbc.M110752200. PMID 11782478.
^ Timothy V Beischlag, Song Wang, David W Rose, Joseph Torchia, Suzanne Reisz-Porszasz, Khurshid Muhammad, Walter E Nelson, Markus R Probst, Michael G Rosenfeld, Oliver Hankinson (15 June 2002). “Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex”. Molecular and Cellular Biology 22 (12): 4319–33. doi:10.1128/mcb.22.12.4319-4333.2002. PMC 133867. PMID 12024042.
^ ^a ^b Markus R. Probst, Chen-Ming Fan, Marc Tessier-Lavigne, Oliver Hankinson (14 February 1997). “Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein”. Journal of Biological Chemistry 272 (7): 4451–7. doi:10.1074/jbc.272.7.4451. PMID 9020169.
^ Norihisa Ooe, Koichi Saito, Nobuyoshi Mikami, Iwao Nakatuka, Hideo Kaneko (15 January 2004). “Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression”. Molecular and Cellular Biology 24 (2): 608–16. doi:10.1128/mcb.24.2.608-616.2004. PMC 343817. PMID 14701734.
^ P Moffett, M Reece, J Pelletier (September 1997). “The murine Sim-2 gene product inhibits transcription by active repression and functional interference”. Molecular and Cellular Biology 17 (9): 4933–47. doi:10.1128/mcb.17.9.4933. PMC 232345. PMID 9271372.

参考文献

Volker H. Haase (01 August 2006). “Hypoxia-inducible factors in the kidney”. American Journal of Physiology-Renal Physiology 291 (2): F271–81. doi:10.1152/ajprenal.00071.2006. PMC 4232221. PMID 16554418.
Herminio Reyes, Suzanne Reisz-Porszasz and Oliver Hankinson (22 May 1992). “Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.”. Science 256 (5060): 1193–5. Bibcode: 1992Sci...256.1193R. doi:10.1126/science.256.5060.1193. PMID 1317062.
E C Hoffman, H Reyes, F F Chu, F Sander, L H Conley, B A Brooks, O Hankinson (17 May 1991). “Cloning of a factor required for activity of the Ah (dioxin) receptor.”. Science 252 (5008): 954–8. Bibcode: 1991Sci...252..954H. doi:10.1126/science.1852076. PMID 1852076.
Yumi Yamaguchi, M. TienKuo (12 October 1995). “Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast two-hybrid system.”. Biochemical Pharmacology 50 (8): 1295–302. doi:10.1016/0006-2952(95)02016-6. PMID 7488247.
G L Wang, B H Jiang, E A Rue, and G L Semenza (6 June 1995). “Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.”. PNAS 92 (12): 5510–4. Bibcode: 1995PNAS...92.5510W. doi:10.1073/pnas.92.12.5510. PMC 41725. PMID 7539918.
M. C. Lindebro, L. Poellinger, M. L. Whitelaw (17 July 1995). “Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex.”. EMBO Journal 14 (14): 3528–39. doi:10.1002/j.1460-2075.1995.tb07359.x. PMC 394421. PMID 7628454.
B. D. Abbott, M. R. Probst, G. H. Perdew (November 1994). “Immunohistochemical double-staining for Ah receptor and ARNT in human embryonic palatal shelves.”. Teratology 50 (5): 361–6. doi:10.1002/tera.1420500507. PMID 7716743.
Suzanne Porszasz-Reisz, Markus Probst, B.N. Fukunaga, Oliver Hankinson (1994). “Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT).”. Molecular and Cellular Biology 14 (9): 6075–86. doi:10.1128/mcb.14.9.6075. PMC 359134. PMID 8065341.
Kazuo Maruyama, Sumio Sugano (28 January 1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.”. Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
B. Johnson, B. A. Brooks, C. Heinzmann, A. Diep, T. Mohandas, R. S. Sparkes, H. Reyes, E. Hoffman, E. Lange, A. Gatti, Y-R. Xia, A. J. Lusis, O. Hankinson (September 1993). “The Ah receptor nuclear translocator gene (ARNT) is located on q21 of human chromosome 1 and on mouse chromosome 3 near Cf-3.”. Genomics 17 (3): 592–8. doi:10.1006/geno.1993.1377. PMID 8244375.
M Whitelaw, I Pongratz, A Wilhelmsson, J A Gustafsson, L Poellinger (1993). “Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor.”. Molecular and Cellular Biology 13 (4): 2504–14. doi:10.1128/MCB.13.4.2504. PMC 359572. PMID 8384309.
Bing-Hua Jiang, Elizabeth Rue, Guang L. Wang, Rick Roe, Gregg L. Semenza (26 July 1996). “Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1.”. Journal of Biological Chemistry 271 (30): 17771–8. doi:10.1074/jbc.271.30.17771. PMID 8663540.
J C Rowlands, I J McEwan, J A Gustafsson (01 September 1996). “Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: direct interactions with basal transcription factors.”. Molecular Pharmacology 50 (3): 538–48. PMID 8794892.
M Ema, M Morita, S Ikawa, M Tanaka, Y Matsuda, O Gotoh, Y Saijoh, H Fujii, H Hamada, Y Kikuchi, Y Fujii-Kuriyama (October 1996). “Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis.”. Molecular and Cellular Biology 16 (10): 5865–75. doi:10.1128/MCB.16.10.5865. PMC 231588. PMID 8927054.
Hollie I. Swanson, Yang Jun-hua (6 December 1997). “Mapping the protein/DNA contact sites of the Ah receptor and Ah receptor nuclear translocator.”. Journal of Biological Chemistry 271 (49): 31657–65. doi:10.1074/jbc.271.49.31657. PMID 8940186.
Markus R. Probst, Chen-Ming Fan, Marc Tessier-Lavigne, Oliver Hankinson (1997). “Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein.”. Journal of Biological Chemistry 272 (7): 4451–7. doi:10.1074/jbc.272.7.4451. PMID 9020169.
John B. Hogenesch, William K. Chan, Victoria H. Jackiw, R. Clark Brown, Yi-Zhong Gu, Marilyn Pray-Grant, Gary H. Perdew, Christopher A. Bradfield (28 March 1997). “Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway.”. Journal of Biological Chemistry 272 (13): 8581–93. doi:10.1074/jbc.272.13.8581. PMID 9079689.
Lucy A. Carver, Christopher A. Bradfield (25 April 1997). “Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo.”. Journal of Biological Chemistry 272 (17): 11452–6. doi:10.1074/jbc.272.17.11452. PMID 9111057.
Masatsugu Ema, Shinichiro Taya, Noboru Yokotani, Kazuhiro Sogawa, Youichi Matsuda, and Yoshiaki Fujii-Kuriyama (19 April 1997). “A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development.”. PNAS 94 (9): 4273–8. doi:10.1073/pnas.94.9.4273. PMC 20712. PMID 9113979.
P Moffett, M Reece, and J Pelletier (September 1997). “The murine Sim-2 gene product inhibits transcription by active repression and functional interference.”. Molecular and Cellular Biology 17 (9): 4933–47. doi:10.1128/mcb.17.9.4933. PMC 232345. PMID 9271372.

外部リンク

Aryl Hydrocarbon Receptor Nuclear Translocator - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス（英語）

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143437 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015522 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[HSP90-2009-5] Duncan Hughes, Joseph B. Guttenplan, Craig B. Marcus, Kotha Subbaramaiah and Andrew J. Dannenberg (5 November 2008). “Heat Shock Protein 90 Inhibitors Suppress Aryl Hydrocarbon Receptor-Mediated Activation of CYP1A1 and CYP1B1 Transcription and DNA Adduct Formation”. Cancer Prevention Research 1 (6): 485–493. doi:10.1158/1940-6207.CAPR-08-0149. PMC 2680610. PMID 19138996.

[pmid9111057-6] Lucy A. Carver, Christopher A. Bradfield (25 April 1997). “Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo”. Journal of Biological Chemistry 272 (17): 11452–6. doi:10.1074/jbc.272.17.11452. PMID 9111057.

[pmid11259606-7] Arunas Kazlauskas, Sara Sundström, Lorenz Poellinger, and Ingemar Pongratz (April 2001). “The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor”. Molecular and Cellular Biology 21 (7): 2594–607. doi:10.1128/MCB.21.7.2594-2607.2001. PMC 86890. PMID 11259606.

[pmid7628454-8] M.C. Lindebro, L. Poellinger, M.L. Whitelaw (01 July 1995). “Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex”. EMBO Journal 14 (14): 3528–39. doi:10.1002/j.1460-2075.1995.tb07359.x. PMC 394421. PMID 7628454.

[pmid8384309-9] M Whitelaw, I Pongratz, A Wilhelmsson, J A Gustafsson, L Poellinger (April 1993). “Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor”. Molecular and Cellular Biology 13 (4): 2504–14. doi:10.1128/MCB.13.4.2504. PMC 359572. PMID 8384309.

[pmid7488247-10] Yumi Yamaguchi, M. Tien Kuo (12 October 1995). “Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast two-hybrid system”. Biochemical Pharmacology 50 (8): 1295–302. doi:10.1016/0006-2952(95)02016-6. PMID 7488247.

[pmid9887096-11] Junsei Mimura, Masatsugu Ema, Kazuhiro Sogawa, and Yoshiaki Fujii-Kuriyama (01 January 1999). “Identification of a novel mechanism of regulation of Ah (dioxin) receptor function”. Genes & Development 13 (1): 20–5. doi:10.1101/gad.13.1.20. PMC 316371. PMID 9887096.

[pmid9079689-12] John B. Hogenesch, William K. Chan, Victoria H. Jackiw, R. Clark Brown, Yi-Zhong Gu, Marilyn Pray-Grant, Gary H. Perdew, Christopher A. Bradfield (28 March 1997). “Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway”. Journal of Biological Chemistry 272 (13): 8581–93. doi:10.1074/jbc.272.13.8581. PMID 9079689.

[pmid11782478-13] Susan L. Woods, Murray L. Whitelaw (22 March 2002). “Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors”. Journal of Biological Chemistry 277 (12): 10236–43. doi:10.1074/jbc.M110752200. PMID 11782478.

[pmid12024042-14] Timothy V Beischlag, Song Wang, David W Rose, Joseph Torchia, Suzanne Reisz-Porszasz, Khurshid Muhammad, Walter E Nelson, Markus R Probst, Michael G Rosenfeld, Oliver Hankinson (15 June 2002). “Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex”. Molecular and Cellular Biology 22 (12): 4319–33. doi:10.1128/mcb.22.12.4319-4333.2002. PMC 133867. PMID 12024042.

[pmid9020169-15] Markus R. Probst, Chen-Ming Fan, Marc Tessier-Lavigne, Oliver Hankinson (14 February 1997). “Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein”. Journal of Biological Chemistry 272 (7): 4451–7. doi:10.1074/jbc.272.7.4451. PMID 9020169.

[pmid14701734-16] Norihisa Ooe, Koichi Saito, Nobuyoshi Mikami, Iwao Nakatuka, Hideo Kaneko (15 January 2004). “Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression”. Molecular and Cellular Biology 24 (2): 608–16. doi:10.1128/mcb.24.2.608-616.2004. PMC 343817. PMID 14701734.

[pmid9271372-17] P Moffett, M Reece, J Pelletier (September 1997). “The murine Sim-2 gene product inhibits transcription by active repression and functional interference”. Molecular and Cellular Biology 17 (9): 4933–47. doi:10.1128/mcb.17.9.4933. PMC 232345. PMID 9271372.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

ARNTとは？わかりやすく解説

Arnt

芳香族炭化水素受容体核内輸送体

相互作用分子

脚注

参考文献

外部リンク

英和和英テキスト翻訳

「ARNT」の関連用語


	Copyright (C) 1994- Nichigai Associates, Inc., All rights reserved.
	All text is available under the terms of the GNU Free Documentation License. この記事は、ウィキペディアの芳香族炭化水素受容体核内輸送体 (改訂履歴)の記事を複製、再配布したものにあたり、GNU Free Documentation Licenseというライセンスの下で提供されています。 Weblio辞書に掲載されているウィキペディアの記事も、全てGNU Free Documentation Licenseの元に提供されております。

ARNTとは？ わかりやすく解説

Arnt

芳香族炭化水素受容体核内輸送体

相互作用分子

脚注

参考文献

外部リンク

英和和英テキスト翻訳

「ARNT」の関連用語

ARNTとは？わかりやすく解説