ミオシン軽鎖ホスファターゼ
(ミオシンL鎖ホスファターゼ から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/01/29 15:30 UTC 版)
ミオシン軽鎖ホスファターゼ（ミオシンけいさホスファターゼ、英: myosin light-chain phosphatase、EC 3.1.3.53、系統名: [myosin-light-chain]-phosphate phosphohydrolase）またはミオシンホスファターゼ（myosin phosphatase）は、ミオシンIIの軽鎖を脱リン酸化する酵素（セリン/スレオニン特異的プロテインホスファターゼ）であり、以下の反応を触媒する。
- ^ a b c d e Terrak, Mohammed; Kerff, Frederic; Langsetmo, Knut; Tao, Terence; Dominguez, Roberto (2004-06-17). “Structural basis of protein phosphatase 1 regulation”. Nature 429 (6993): 780–784. doi:10.1038/nature02582. ISSN 1476-4687. PMID 15164081.
- ^ a b c Hartshorne, DJ; Ito, M (May 1998). “Myosin Light Chain Phosphatase: Subunit Composition, Interactions and Regulation”. J Muscle Res Cell Motil. 19 (4): 325–41. doi:10.1023/A:1005385302064. PMID 9635276.
- ^ Page 174 in: The vascular smooth muscle cell: molecular and biological responses to the extracellular matrix. Authors: Stephen M. Schwartz, Robert P. Mecham. Editors: Stephen M. Schwartz, Robert P. Mecham. Contributors: Stephen M. Schwartz, Robert P. Mecham. Publisher: Academic Press, 1995. ISBN 0-12-632310-0, ISBN 978-0-12-632310-8
- ^ a b Webb, R. Clinton (November 2003). “Smooth Muscle Contraction and Relaxation”. Advances in Physiology Education 27 (4): 201–6. doi:10.1152/advan.00025.2003. PMID 14627615.
- ^ Hurley, Thomas D.; Yang, Jie; Zhang, Lili; Goodwin, Kristie D.; Zou, Qin; Cortese, Marc; Dunker, A. Keith; DePaoli-Roach, Anna A. (2007-09-28). “Structural basis for regulation of protein phosphatase 1 by inhibitor-2”. The Journal of Biological Chemistry 282 (39): 28874–28883. doi:10.1074/jbc.M703472200. ISSN 0021-9258. PMID 17636256.
- ^ Cohen, Patricia T. W. (January 15, 2002). “Protein Phosphatase 1-Targeted in Many Directions”. J Cell Sci 115 (2): 780–4. doi:10.1242/jcs.115.2.241. PMID 11839776.
- ^ Fujioka, M; Takahashi, N (April 1, 1998). “A New Isoform of Human Myosin Phosphatase Targeting/Regulatory Subunit (MYPT2): cDNA Cloning, Tissue Expression, and Chromosomal Mapping”. Genomics 49 (1): 325–41. doi:10.1006/geno.1998.5222. PMID 9570949.
- ^ Gomperts, Bastein D. (August 19, 2009). Signal Transduction: 2nd Edition. London: Academic Press. ISBN 978-0123694416
- ^ Shi, Yigong (October 30, 2009). “Serine/Threonine Phosphatases: Mechanism through Structure”. Cell 139 (3): 468–84. doi:10.1016/j.cell.2009.10.006. PMID 19879837.
- ^ Lee, E. Y.; Zhang, L.; Zhao, S.; Wei, Q.; Zhang, J.; Qi, Z. Q.; Belmonte, E. R. (1999-03-15). “Phosphorylase phosphatase: new horizons for an old enzyme”. Frontiers in Bioscience: A Journal and Virtual Library 4: D270–285. doi:10.2741/lee. ISSN 1093-9946. PMID 10077543.
- ^ Wang, Yuepeng; Zheng, Xiaoyu Rayne; Riddick, Nadeene; Bryden, Meredith; Baur, Wendy; Zhang, Xin; Surks, Howard K. (2009-02-27). “ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells”. Circulation Research 104 (4): 531–540. doi:10.1161/CIRCRESAHA.108.188524. ISSN 1524-4571. PMC 2649695. PMID 19131646.
- ^ a b Khromov, Alexander S.; Momotani, Ko; Jin, Li; Artamonov, Mykhaylo V.; Shannon, John; Eto, Masumi; Somlyo, Avril V. (2012-06-15). “Molecular mechanism of telokin-mediated disinhibition of myosin light chain phosphatase and cAMP/cGMP-induced relaxation of gastrointestinal smooth muscle”. The Journal of Biological Chemistry 287 (25): 20975–20985. doi:10.1074/jbc.M112.341479. ISSN 1083-351X. PMC 3375521. PMID 22544752.
- ^ Somlyo, Andrew P.; Somlyo, Avril V. (November 10, 1999). “Signal Transduction by G-Proteins, Rho-Kinase and Protein Phosphatase to Smooth Muscle and Non-Muscle Myosin II”. Journal of Physiology 522 (2): 177–85. doi:10.1111/j.1469-7793.2000.t01-2-00177.x. PMC 2269761. PMID 10639096.
- ^ a b Gong, M. C.; Fuglsang, A.; Alessi, D.; Kobayashi, S.; Cohen, P.; Somlyo, A. V.; Somlyo, A. P. (1992-10-25). “Arachidonic acid inhibits myosin light chain phosphatase and sensitizes smooth muscle to calcium”. The Journal of Biological Chemistry 267 (30): 21492–21498. ISSN 0021-9258. PMID 1328235.
- ^ Feng, J.; Ito, M.; Kureishi, Y.; Ichikawa, K.; Amano, M.; Isaka, N.; Okawa, K.; Iwamatsu, A. et al. (1999-02-05). “Rho-associated kinase of chicken gizzard smooth muscle”. The Journal of Biological Chemistry 274 (6): 3744–3752. doi:10.1074/jbc.274.6.3744. ISSN 0021-9258. PMID 9920927.
- ^ Aguilar, Hector; Mitchell, B.F. (May 7, 2010). “Physiological Pathways and Molecular Mechanisms Regulating Uterine Contractility”. Human Reproduction Update 16 (6): 725–44. doi:10.1093/humupd/dmq016. PMID 20551073.
[続きの解説]
「ミオシン軽鎖ホスファターゼ」の続きの解説一覧
- 1 ミオシン軽鎖ホスファターゼとは
- 2 ミオシン軽鎖ホスファターゼの概要
- 3 機構
- 4 関連文献
- 5 関連項目
- ミオシン軽鎖ホスファターゼのページへのリンク
