シスタチンC
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/12/09 13:42 UTC 版)
シスタチンC（英: cystatin C）は血清タンパク質のひとつであり、シスタチンスーパーファミリーの2型に属するアミノ酸120残基のポリペプチドである。ヒトではCST3遺伝子にコードされる。全身の有核細胞で産生され、システインプロテアーゼインヒビターとして、生体内で働いている。血中のシスタチンCは腎糸球体で濾過され、近位尿細管で再吸収される。クレアチニンが筋肉量の影響を受け、男女差がみられるのに対し、シスタチンCはそのような性質はなく、糸球体濾過量（GFR） のマーカーとして優れている。こうした腎臓機能のバイオマーカーとしての役割の他に、心血管疾患の予測における役割の研究も近年では行われている。また、アルツハイマー病など、アミロイドが関係する脳疾患にも関与しているようである。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000101439 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027447 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
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