エズリン
エズリン
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2020/03/31 16:59 UTC 版)
エズリン(Ezrin)は、ヒトではEZR遺伝子によりコードされるタンパク質である[5]。モエシン、ラディキシンとともにERMファミリーを構成する。シトビリン(cytovillin)やビリン2(Villin-2)とも呼ばれる。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000092820 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052397 - Ensembl, May 2017
- ^ "Human PubMed Reference:".
- ^ "Mouse PubMed Reference:".
- ^ “cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1”. EMBO J. 8 (13): 4133-42. (December 1989). PMC: 401598. PMID 2591371.
- ^ “Entrez Gene: VIL2 villin 2 (ezrin)”. 2020年3月31日閲覧。
- ^ “Activation of nanoscale allosteric protein domain motion revealed by neutron spin echo spectroscopy”. Biophysical Journal 99 (10): 3473-82. (2010). doi:10.1016/j.bpj.2010.09.058. PMC: 2980739. PMID 21081097.
- ^ “Open conformation of ezrin bound to phosphatidylinositol 4,5-bisphosphate and to F-actin revealed by neutron scattering”. J. Biol. Chem. 287 (44): 37119-33. (2012). doi:10.1074/jbc.M112.380972. PMC: 3481312. PMID 22927432.
- ^ “Mode of Ezrin-Membrane Interaction as a Function of PIP2 Binding and Pseudophosphorylation”. Biophys. J. 110 (12): 2710-2719. (2016). doi:10.1016/j.bpj.2016.05.009. PMC: 4919509. PMID 27332129.
- ^ “Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes”. Immunology 112 (2): 165-176. (2004). doi:10.1111/j.1365-2567.2004.01882.x. PMC: 1782489. PMID 15147559.
- ^ “CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts”. Blood 91 (12): 4632-44. (June 1998). PMID 9616160.
- ^ a b “Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy”. J. Biol. Chem. 280 (12): 11641-7. (March 2005). doi:10.1074/jbc.M411781200. PMID 15659383.
- ^ “CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway”. EMBO J. 19 (19): 5123-34. (October 2000). doi:10.1093/emboj/19.19.5123. PMC: 302100. PMID 11013215.
- ^ a b c “Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate”. J. Biol. Chem. 273 (34): 21893-900. (August 1998). doi:10.1074/jbc.273.34.21893. PMID 9705328.
- ^ “A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting”. J. Biol. Chem. 277 (12): 10400-9. (March 2002). doi:10.1074/jbc.M110694200. PMID 11784723.
- ^ “Homotypic and heterotypic interaction of the neurofibromatosis 2 tumor suppressor protein merlin and the ERM protein ezrin”. J. Cell Sci. 112 (6): 895-904. (March 1999). PMID 10036239.
- ^ “Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site”. Mol. Biol. Cell 6 (8): 1061-75. (August 1995). doi:10.1091/mbc.6.8.1061. PMC: 301263. PMID 7579708.
- ^ “Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins”. Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10846-50. (November 1993). doi:10.1073/pnas.90.22.10846. PMC: 47875. PMID 8248180.
- ^ “Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway”. Proc. Natl. Acad. Sci. U.S.A. 96 (13): 7300-5. (June 1999). doi:10.1073/pnas.96.13.7300. PMC: 22080. PMID 10377409.
- ^ “Characterization of human palladin, a microfilament-associated protein”. Mol. Biol. Cell 12 (10): 3060-73. (October 2001). doi:10.1091/mbc.12.10.3060. PMC: 60155. PMID 11598191.
- ^ “Ca2+-dependent binding and activation of dormant ezrin by dimeric S100P”. Mol. Biol. Cell 14 (6): 2372-84. (June 2003). doi:10.1091/mbc.E02-09-0553. PMC: 194886. PMID 12808036.
- ^ “Ezrin links syndecan-2 to the cytoskeleton”. J. Cell Sci. 113 (7): 1267-76. (April 2000). PMID 10704377.
- ^ “Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton”. FEBS Lett. 507 (2): 133-6. (October 2001). doi:10.1016/s0014-5793(01)02955-6. PMID 11684085.
- ^ “Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family”. J. Cell Biol. 139 (1): 169-79. (October 1997). doi:10.1083/jcb.139.1.169. PMC: 2139813. PMID 9314537.
- ^ “NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrin”. J. Biol. Chem. 273 (40): 25856-63. (October 1998). doi:10.1074/jbc.273.40.25856. PMID 9748260.
- ^ “The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation”. J. Biol. Chem. 277 (36): 33188-95. (September 2002). doi:10.1074/jbc.M202522200. PMID 12080047.
- ^ “Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes”. J. Cell Biol. 157 (7): 1233-45. (June 2002). doi:10.1083/jcb.200112126. PMC: 2173557. PMID 12082081.
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