ｄＡＭＰ
| 分子式： | C10H14N5O6P |
| その他の名称： | 2'-デオキシアデニル酸、2'-デオキシ-AMP、2'-デオキシ-5'-AMP、デオキシ-5'-アデニル酸、デオキシ-AMP、デオキシアデノシン5'-一りん酸、デオキシアデノシン一りん酸、デオキシアデノシン5'-りん酸、2'-デオキシアデノシン一りん酸、Deoxyadenylic acid、PdA、2'-dAMP、dAMP、2'-Deoxy-AMP、2'-Deoxy-5'-AMP、Deoxy-5'-adenylic acid、Deoxy-AMP、Deoxyadenosine 5'-monophosphate、Deoxyadenosine monophosphate、Deoxyadenosine 5'-phosphate、2'-Deoxyadenosine monophosphate、2'-Deoxyadenylic acid、デオキシアデニル酸、2'-Deoxyadenosine 5'-phosphoric acid、2'-Deoxy-5'-adenylic acid、2'-Deoxyadenosine-5'-phosphoric acid、2'-Deoxyadenosine 5'-phosphate |
| 体系名： | 2'-デオキシアデノシン5'-りん酸、2'-デオキシ-5'-アデニル酸、2'-デオキシアデノシン-5'-りん酸 |
ダメージ関連分子パターン
(damp から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/04/08 07:26 UTC 版)
ダメージ関連分子パターン（英: damage-associated molecular patterns、DAMP）は[1]、危険関連分子パターン、危険信号、およびアラーミンとも呼ばれ、非感染性の炎症反応を開始し、永続化できる宿主生体分子である。例えば、これらは損傷した細胞または死滅した細胞から放出され、パターン認識受容体（PRR）と相互作用することにより自然免疫系を活性化する[2]。対照的に、病原体関連分子パターン（PAMP）は、感染性病原体誘導性炎症反応を開始し、永続化させる[3]。多くのDAMPは、細胞内機能が定義された核内または細胞質タンパク質であり、組織損傷後に細胞外に放出されると、還元性環境から酸化性環境へと移行し、機能変性をもたらす[4]。これらのDAMPの他にも、ECM（細胞外マトリックス）、ミトコンドリア、顆粒、ER（小胞体）、形質膜など、さまざまな供給源に由来する他のDAMPが存在する。
- ^ a b Seong SY, Matzinger P (June 2004). “Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses”. Nature Reviews. Immunology 4 (6): 469–78. doi:10.1038/nri1372. PMID 15173835.
- ^ a b c d e Roh JS, Sohn DH (August 2018). “Damage-Associated Molecular Patterns in Inflammatory Diseases” (English). Immune Network 18 (4): e27. doi:10.4110/in.2018.18.e27. PMC 6117512. PMID 30181915.
- ^ Janeway C (September 1989). “Immunogenicity signals 1,2,3 ... and 0”. Immunology Today 10 (9): 283–6. doi:10.1016/0167-5699(89)90081-9. PMID 2590379.
- ^ Rubartelli A, Lotze MT (October 2007). “Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox”. Trends in Immunology 28 (10): 429–36. doi:10.1016/j.it.2007.08.004. PMID 17845865.
- ^ a b Farkas AM, Kilgore TM, Lotze MT (December 2007). “Detecting DNA: getting and begetting cancer”. Current Opinion in Investigational Drugs 8 (12): 981–6. PMID 18058568.
- ^ Land W, Schneeberger H, Schleibner S, Illner WD, Abendroth D, Rutili G, Arfors KE, Messmer K (January 1994). “The beneficial effect of human recombinant superoxide dismutase on acute and chronic rejection events in recipients of cadaveric renal transplants”. Transplantation 57 (2): 211–7. doi:10.1097/00007890-199401001-00010. PMID 8310510.
- ^ Matzinger P (1994). “Tolerance, danger, and the extended family”. Annual Review of Immunology 12: 991–1045. doi:10.1146/annurev.iy.12.040194.005015. PMID 8011301.
- ^ Panayi GS, Corrigall VM, Henderson B (August 2004). “Stress cytokines: pivotal proteins in immune regulatory networks; Opinion”. Current Opinion in Immunology 16 (4): 531–4. doi:10.1016/j.coi.2004.05.017. PMID 15245751.
- ^ a b Scaffidi P, Misteli T, Bianchi ME (July 2002). “Release of chromatin protein HMGB1 by necrotic cells triggers inflammation”. Nature 418 (6894): 191–5. doi:10.1038/nature00858. PMID 12110890.
- ^ Scheibner KA, Lutz MA, Boodoo S, Fenton MJ, Powell JD, Horton MR (July 2006). “Hyaluronan fragments act as an endogenous danger signal by engaging TLR2”. Journal of Immunology 177 (2): 1272–81. doi:10.4049/jimmunol.177.2.1272. PMID 16818787.
- ^ Boeynaems JM, Communi D (May 2006). “Modulation of inflammation by extracellular nucleotides”. The Journal of Investigative Dermatology 126 (5): 943–4. doi:10.1038/sj.jid.5700233. PMID 16619009.
- ^ Bours MJ, Swennen EL, Di Virgilio F, Cronstein BN, Dagnelie PC (November 2006). “Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation”. Pharmacology & Therapeutics 112 (2): 358–404. doi:10.1016/j.pharmthera.2005.04.013. PMID 16784779.
- ^ Shi Y, Evans JE, Rock KL (October 2003). “Molecular identification of a danger signal that alerts the immune system to dying cells”. Nature 425 (6957): 516–21. Bibcode: 2003Natur.425..516S. doi:10.1038/nature01991. PMID 14520412.
- ^ Gardella S, Andrei C, Ferrera D, Lotti LV, Torrisi MR, Bianchi ME, Rubartelli A (October 2002). “The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway”. EMBO Reports 3 (10): 995–1001. doi:10.1093/embo-reports/kvf198. PMC 1307617. PMID 12231511.
- ^ Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, Frazier A, Yang H, Ivanova S, Borovikova L, Manogue KR, Faist E, Abraham E, Andersson J, Andersson U, Molina PE, Abumrad NN, Sama A, Tracey KJ (July 1999). “HMG-1 as a late mediator of endotoxin lethality in mice”. Science 285 (5425): 248–51. doi:10.1126/science.285.5425.248. PMID 10398600.
- ^ a b Ibrahim ZA, Armour CL, Phipps S, Sukkar MB (December 2013). “RAGE and TLRs: relatives, friends or neighbours?”. Molecular Immunology 56 (4): 739–44. doi:10.1016/j.molimm.2013.07.008. PMID 23954397.
- ^ Galbiati V, Papale A, Galli CL, Marinovich M, Corsini E (November 2014). “Role of ROS and HMGB1 in contact allergen-induced IL-18 production in human keratinocytes”. The Journal of Investigative Dermatology 134 (11): 2719–2727. doi:10.1038/jid.2014.203. PMID 24780928.
- ^ Bernard JJ, Cowing-Zitron C, Nakatsuji T, Muehleisen B, Muto J, Borkowski AW, Martinez L, Greidinger EL, Yu BD, Gallo RL (August 2012). “Ultraviolet radiation damages self noncoding RNA and is detected by TLR3”. Nature Medicine 18 (8): 1286–90. doi:10.1038/nm.2861. PMC 3812946. PMID 22772463.
- ^ Diederichs S, Bulk E, Steffen B, Ji P, Tickenbrock L, Lang K, Zänker KS, Metzger R, Schneider PM, Gerke V, Thomas M, Berdel WE, Serve H, Müller-Tidow C (August 2004). “S100 family members and trypsinogens are predictors of distant metastasis and survival in early-stage non-small cell lung cancer”. Cancer Research 64 (16): 5564–9. doi:10.1158/0008-5472.CAN-04-2004. PMID 15313892.
- ^ Emberley ED, Murphy LC, Watson PH (2004). “S100A7 and the progression of breast cancer”. Breast Cancer Research 6 (4): 153–9. doi:10.1186/bcr816. PMC 468668. PMID 15217486.
- ^ Emberley ED, Murphy LC, Watson PH (August 2004). “S100 proteins and their influence on pro-survival pathways in cancer”. Biochemistry and Cell Biology 82 (4): 508–15. doi:10.1139/o04-052. PMID 15284904.
- ^ Lin J, Yang Q, Yan Z, Markowitz J, Wilder PT, Carrier F, Weber DJ (August 2004). “Inhibiting S100B restores p53 levels in primary malignant melanoma cancer cells”. The Journal of Biological Chemistry 279 (32): 34071–7. doi:10.1074/jbc.M405419200. PMID 15178678.
- ^ Marenholz I, Heizmann CW, Fritz G (October 2004). “S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature)”. Biochemical and Biophysical Research Communications 322 (4): 1111–22. doi:10.1016/j.bbrc.2004.07.096. PMID 15336958.
- ^ a b Maverakis E, Kim K, Shimoda M, Gershwin ME, Patel F, Wilken R, Raychaudhuri S, Ruhaak LR, Lebrilla CB (February 2015). “Glycans in the immune system and The Altered Glycan Theory of Autoimmunity: a critical review”. Journal of Autoimmunity 57: 1–13. doi:10.1016/j.jaut.2014.12.002. PMC 4340844. PMID 25578468.
- ^ a b Russo MV, McGavern DB (October 2015). “Immune Surveillance of the CNS following Infection and Injury”. Trends in Immunology 36 (10): 637–50. doi:10.1016/j.it.2015.08.002. PMC 4592776. PMID 26431941.
- ^ Zeh HJ, Lotze MT (2005). “Addicted to death: invasive cancer and the immune response to unscheduled cell death”. Journal of Immunotherapy 28 (1): 1–9. doi:10.1097/00002371-200501000-00001. PMID 15614039.
- ^ Kurashima Y, Kiyono H (March 2014). “New era for mucosal mast cells: their roles in inflammation, allergic immune responses and adjuvant development”. Experimental & Molecular Medicine 46 (3): e83. doi:10.1038/emm.2014.7. PMC 3972796. PMID 24626169.
- ^ Kurashima Y, Amiya T, Nochi T, Fujisawa K, Haraguchi T, Iba H, Tsutsui H, Sato S, Nakajima S, Iijima H, Kubo M, Kunisawa J, Kiyono H (2012). “Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors”. Nature Communications 3: 1034. Bibcode: 2012NatCo...3.1034K. doi:10.1038/ncomms2023. PMC 3658010. PMID 22948816.
- ^ Choi, Hyong Woo; Klessig, Daniel F. (December 2016). “DAMPs, MAMPs, and NAMPs in plant innate immunity” (英語). BMC Plant Biology 16 (1): 232. doi:10.1186/s12870-016-0921-2. ISSN 1471-2229. PMC 5080799. PMID 27782807.
- ^ Anders HJ, Schaefer L (July 2014). “Beyond tissue injury-damage-associated molecular patterns, toll-like receptors, and inflammasomes also drive regeneration and fibrosis”. Journal of the American Society of Nephrology 25 (7): 1387–400. doi:10.1681/ASN.2014010117. PMC 4073442. PMID 24762401.
[続きの解説]
「ダメージ関連分子パターン」の続きの解説一覧
- 1 ダメージ関連分子パターンとは
- 2 ダメージ関連分子パターンの概要
- 3 さまざまな疾患の臨床標的
- 4 関連項目
- dampのページへのリンク
