毛細血管漏出症候群
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/06/24 15:09 UTC 版)
毛細血管漏出症候群（Capillary leak syndrome）は、毛細血管の壁を通って血液循環系から周囲の組織、筋肉区画、臓器、体腔に血漿が漏出することを特徴とする。敗血症、自己免疫疾患、分化症候群、生着症候群、血球貪食性リンパ組織球症、卵巣過剰刺激症候群、ウイルス性出血熱、蛇毒・リシン中毒などでよく見られる現象である[1]。また、化学療法薬のゲムシタビンやタグラクソフスプ、特定のインターロイキンやモノクローナル抗体などの医薬品も、毛細血管のリークを引き起こす可能性がある[1]。これらの症状や要因は、二次性毛細血管漏出症候群の原因となりうる。
- ^ a b Siddall, Eric; Khatri, Minesh; Radhakrishnan, Jai (16 March 2017). “Capillary leak syndrome: etiologies, pathophysiology, and management.”. Kidney International 92 (1): 37-46. doi:10.1016/j.kint.2016.11.029. PMID 28318633.
- ^ a b c d e f g h i j k l m n o Druey, Kirk M.; Greipp, Philip R. (2010). “Narrative Review: Clarkson Disease-Systemic Capillary Leak Syndrome”. Annals of Internal Medicine 153 (2): 90-98. doi:10.7326/0003-4819-153-2-201007200-00005. PMC 3017349. PMID 20643990.
- ^ a b c d e f g h i j k l m n o p q r Druey, Kirk; Parikh, Samir M. (22 December 2016). “Idiopathic systemic capillary leak syndrome (Clarkson disease)”. Journal of Allergy and Clinical Immunology 140 (3): 663-670. doi:10.1016/j.jaci.2016.10.042. PMC 5481509. PMID 28012935.
- ^ a b c d e f g h Pineton Chambrun, Marc (2017). “The Clinical Picture of Severe Systemic Capillary-Leak Syndrome Episodes Requiring ICU Admission”. Critical Care Medicine 45 (7): 1216-1223. doi:10.1097/CCM.0000000000002496. PMID 28622216.
- ^ a b c d Xie, Zhihui; Ghosh, Chandra C.; Patel, Roshni; Iwaki, Shoko; Gaskins, Donna; Nelson, Celeste; Jones, Nina; Greipp, Philip R. et al. (2012-05-03). “Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome)” (英語). Blood 119 (18): 4321-4332. doi:10.1182/blood-2011-08-375816. ISSN 0006-4971. PMC 3359743. PMID 22411873.
- ^ Xie, Zhihui; Ghosh, Chandra C.; Parikh, Samir M.; Druey, Kirk M. (2014). “Mechanistic Classification of the Systemic Capillary Leak Syndrome: Clarkson Disease”. American Journal of Respiratory and Critical Care Medicine 189 (9): 1145-1147. doi:10.1164/rccm.201310-1746LE. PMC 4098109. PMID 24787070.
- ^ a b c Droder, Robert M.; Kyle, Robert A.; Greipp, Philip R. (1992). “Control of systemic capillary leak syndrome with aminophylline and terbutaline”. The American Journal of Medicine 92 (5): 523-526. doi:10.1016/0002-9343(92)90749-2. PMID 1580299.
- ^ Kapoor, Prashant; Greipp, Patricia T.; Schaefer, Eric W.; Mandrekar, Sumithra J.; Kamal, Arif H.; Gonzalez-Paz, Natalia C.; Kumar, Shaji; Greipp, Philip R. (2010). “Idiopathic Systemic Capillary Leak Syndrome (Clarkson's Disease): The Mayo Clinic Experience”. Mayo Clinic Proceedings 85 (10): 905-912. doi:10.4065/mcp.2010.0159. PMC 2947962. PMID 20634497.
- ^ a b c d Xie, Zhihui; Chan, Eunice C.; Long, Lauren M.; Nelson, Celeste; Druey, Kirk M. (2015-01). “High-dose Intravenous Immunoglobulin Therapy for Systemic Capillary Leak Syndrome (Clarkson Disease)” (英語). The American Journal of Medicine 128 (1): 91-95. doi:10.1016/j.amjmed.2014.08.015. PMC 4282822. PMID 25193271.
- ^ a b c d e f Pineton de Chambrun, Marc (June 8, 2017). “Intravenous immunoglobulins improve survival in monoclonal gammopathy-associated systemic capillary-leak syndrome”. The American Journal of Medicine 130 (10): 1219.e19-1219.e27. doi:10.1016/j.amjmed.2017.05.023. PMID 28602874.
- ^ a b Lambert, Marc; Launay, David; Hachulla, Eric; Morell-Dubois, Sandrine; Soland, Vincent; Queyrel, Viviane; Fourrier, François; Hatron, Pierre-Yves (2008). “High-dose intravenous immunoglobulins dramatically reverse systemic capillary leak syndrome”. Critical Care Medicine 36 (7): 2184-2187. doi:10.1097/CCM.0b013e31817d7c71. PMID 18552679.
- ^ Clarkson, Bayard; Thompson, David; Horwith, Melvin; Luckey, E.Hugh (1960). “Cyclical edema and shock due to increased capillary permeability”. The American Journal of Medicine 29 (2): 193-216. doi:10.1016/0002-9343(60)90018-8. PMID 13693909.
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- 2 毛細血管漏出症候群の概要
- 3 治療
- 4 予後
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