サイクリンC
(cyclin C から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/12/04 02:24 UTC 版)
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サイクリンC（英: cyclin C）は、ヒトではCCNC遺伝子にコードされるタンパク質である[5][6]。
CCNC遺伝子にコードされるサイクリンCは、サイクリンファミリーに属するタンパク質である。サイクリンCはサイクリン依存性キナーゼ8と相互作用し、RNAポリメラーゼIIの大サブユニットのC末端ドメインのリン酸化を誘導する。この遺伝子のmRNAレベルは細胞周期のG1期にピークに達する。この遺伝子には異なるアイソフォームをコードする2つの転写バリアントが見つかっている[6]。
相互作用
サイクリンCはエストロゲン受容体α[7]、サイクリン依存性キナーゼ8と相互作用することが示されている[7][8][9][10][11]。
出典
- ^ a b c GRCh38: Ensembl release 89: ENSG00000112237 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028252 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast”. Cell 66 (6): 1197–206. (Oct 1991). doi:10.1016/0092-8674(91)90042-W. PMID 1833066.
- ^ a b “Entrez Gene: CCNC cyclin C”. 2021年11月22日閲覧。
- ^ a b Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). “The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the TRAP220 subunit and directly enhances estrogen receptor function in vitro”. Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2642–7. Bibcode: 2002PNAS...99.2642K. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769.
- ^ Zhang, Y; Iratni R; Erdjument-Bromage H; Tempst P; Reinberg D (May 1997). “Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex”. Cell 89 (3): 357–64. doi:10.1016/S0092-8674(00)80216-0. ISSN 0092-8674. PMID 9150135.
- ^ Cho, H; Orphanides G; Sun X; Yang X J; Ogryzko V; Lees E; Nakatani Y; Reinberg D (Sep 1998). “A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure”. Mol. Cell. Biol. 18 (9): 5355–63. doi:10.1128/MCB.18.9.5355. ISSN 0270-7306. PMC 109120. PMID 9710619.
- ^ Wang, G; Cantin G T; Stevens J L; Berk A J (Jul 2001). “Characterization of Mediator Complexes from HeLa Cell Nuclear Extract”. Mol. Cell. Biol. 21 (14): 4604–13. doi:10.1128/MCB.21.14.4604-4613.2001. ISSN 0270-7306. PMC 87123. PMID 11416138.
- ^ Tassan, J P; Jaquenoud M; Léopold P; Schultz S J; Nigg E A (Sep 1995). “Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C”. Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8871–5. Bibcode: 1995PNAS...92.8871T. doi:10.1073/pnas.92.19.8871. ISSN 0027-8424. PMC 41069. PMID 7568034.
関連文献
- “Magnetic circular dichroism on the reversible oxygenation of dimethylmesoporphyrin-IX-atopyridinecobalt (II)”. Bioinorganic Chemistry 5 (3): 267–73. (1976). doi:10.1016/S0006-3061(00)82025-6. PMID 1260071.
- “Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C”. Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8871–5. (1995). Bibcode: 1995PNAS...92.8871T. doi:10.1073/pnas.92.19.8871. PMC 41069. PMID 7568034.
- “Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)”. Cytogenet. Cell Genet. 69 (3–4): 190–2. (1995). doi:10.1159/000133960. PMID 7698009.
- “Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts”. J. Clin. Invest. 95 (5): 2275–80. (1995). doi:10.1172/JCI117918. PMC 295840. PMID 7738192.
- “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene 138 (1–2): 171–4. (1994). doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- “Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II”. Oncogene 12 (12): 2631–40. (1996). PMID 8700522.
- “Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors”. Genomics 32 (2): 253–9. (1997). doi:10.1006/geno.1996.0112. PMID 8833152.
- “The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme”. Mol. Cell. Biol. 17 (4): 1817–23. (1997). doi:10.1128/MCB.17.4.1817. PMC 232028. PMID 9121429.
- “Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene 200 (1–2): 149–56. (1997). doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- “Factors associated with the mammalian RNA polymerase II holoenzyme”. Nucleic Acids Res. 26 (3): 847–53. (1998). doi:10.1093/nar/26.3.847. PMC 147327. PMID 9443979.
- “A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure”. Mol. Cell. Biol. 18 (9): 5355–63. (1998). doi:10.1128/MCB.18.9.5355. PMC 109120. PMID 9710619.
- “NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription”. Mol. Cell 2 (2): 213–22. (1998). doi:10.1016/S1097-2765(00)80131-8. PMID 9734358.
- “A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation”. Mol. Cell 3 (1): 97–108. (1999). doi:10.1016/S1097-2765(00)80178-1. PMID 10024883.
- “Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators”. Mol. Cell 3 (3): 361–70. (1999). doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
- “Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex”. Nature 398 (6730): 824–8. (1999). Bibcode: 1999Natur.398..824R. doi:10.1038/19783. PMID 10235266.
- “Characterization of Mediator Complexes from HeLa Cell Nuclear Extract”. Mol. Cell. Biol. 21 (14): 4604–13. (2001). doi:10.1128/MCB.21.14.4604-4613.2001. PMC 87123. PMID 11416138.
- “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. (2003). Bibcode: 2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- “Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3”. J. Biol. Chem. 278 (17): 15123–7. (2003). doi:10.1074/jbc.C300054200. PMID 12584197.
- “Cyclin C expression is involved in the pathogenesis of Alzheimer's disease”. Neurobiol. Aging 24 (3): 427–35. (2003). doi:10.1016/S0197-4580(02)00132-X. PMID 12600719.
外部リンク
- Human CCNC genome location and CCNC gene details page in the UCSC Genome Browser.
- サイクリンCのページへのリンク
