ATP感受性カリウムチャネル
(atp-sensitive potassium channel から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/11/06 01:49 UTC 版)
ATP感受性カリウムチャネル（ATPかんじゅせいカリウムチャネル、英: ATP-sensitive potassium channel）またはKATPチャネルは、細胞内のヌクレオチド、ATPとADPによって開口が制御されるカリウムチャネルのタイプである。ATP感受性カリウムチャネルはKir6.x型サブユニットとスルホニルウレア受容体サブユニット、そして他の付加的な構成要素から構成される[1]。KATPチャネルは主に細胞膜に存在するが、一部は細胞の他の区画の膜にも存在する。筋鞘に存在するものはsarcKATP、ミトコンドリアの膜に存在するものはmitoKATP、核膜に存在するものはnucKATPと分類される場合もある。
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- ^ “Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells”. Endocrinology 142 (1): 129–38. (January 2001). doi:10.1210/en.142.1.129. PMID 11145575.
- ^ “Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells”. Circ. Res. 88 (12): 1267–75. (June 2001). doi:10.1161/hh1201.092094. PMID 11420303.
- ^ “Chronic mild hypoxia protects heart-derived H9c2 cells against acute hypoxia/reoxygenation by regulating expression of the SUR2A subunit of the ATP-sensitive K+ channel”. J. Biol. Chem. 278 (33): 31444–55. (August 2003). doi:10.1074/jbc.M303051200. PMC 2134977. PMID 12791696.
- ^ “Altered mRNA expression of ATP-sensitive and inward rectifier potassium channel subunits in streptozotocin-induced diabetic rat heart and aorta”. J. Pharmacol. Sci. 93 (4): 478–83. (December 2003). doi:10.1254/jphs.93.478. PMID 14737020.
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- ^ “ATP4- mediates closure of pancreatic beta-cell ATP-sensitive potassium channels by interaction with 1 of 4 identical sites”. Diabetes 49 (9): 1413–8. (September 2000). doi:10.2337/diabetes.49.9.1413. PMID 10969823.
- ^ Koster, J.; Marshall, B.A.; Ensor, N.; Corbett, J.A.; Nichols, C.G. (2000). “Targeted Overactivity of β Cell KATP Channels Induces Profound Neonatal Diabetes”. Cell 100 (6): 645–654. doi:10.1016/S0092-8674(00)80701-1. PMID 10761930.
- ^ Koster, J. C.; Knopp, A.; Flagg, T. P.; Markova, K. P.; Sha, Q.; Enkvetchakul, D.; Betsuyaku, T.; Yamada, K. A. et al. (2001). “Tolerance for ATP-Insensitive KATP Channels in Transgenic Mice”. Circulation Research 89 (11): 1022–9. doi:10.1161/hh2301.100342. PMID 11717159.
- ^ “Mitochondrial K(ATP) channel activation reduces anoxic injury by restoring mitochondrial membrane potential”. Am. J. Physiol. Heart Circ. Physiol. 281 (3): H1295–303. (September 2001). doi:10.1152/ajpheart.2001.281.3.H1295. PMID 11514300.
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- ^ “Cardioprotective effect of diazoxide is mediated by activation of sarcolemmal but not mitochondrial ATP-sensitive potassium channels in mice”. Circulation 107 (5): 682–5. (February 2003). doi:10.1161/01.CIR.0000055187.67365.81. PMID 12578868.
- ^ “A K(ATP) channel deficiency affects resting tension, not contractile force, during fatigue in skeletal muscle”. Am. J. Physiol., Cell Physiol. 279 (5): C1351–8. (November 2000). doi:10.1152/ajpcell.2000.279.5.C1351. PMID 11029282.
- ^ “Kir6.2 is required for adaptation to stress”. Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13278–83. (October 2002). doi:10.1073/pnas.212315199. PMC 130624. PMID 12271142.
- ^ “Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 K(ATP) channels”. J. Clin. Invest. 110 (2): 203–8. (July 2002). doi:10.1172/JCI15672. PMC 151064. PMID 12122112.
- ^ “ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating”. Nat. Genet. 36 (4): 382–7. (April 2004). doi:10.1038/ng1329. PMC 1995438. PMID 15034580.
[続きの解説]
「ATP感受性カリウムチャネル」の続きの解説一覧
- 1 ATP感受性カリウムチャネルとは
- 2 ATP感受性カリウムチャネルの概要
- 3 心血管のKATPと虚血性障害からの保護
- 4 関連文献
- 5 関連項目
- ATP感受性カリウムチャネルのページへのリンク
