ホスホエノールピルビン酸カルボキシキナーゼ
同義/類義語：ホスホエノールピルベートカルボキシキナーゼ
英訳・(英)同義/類義語：carboxykinase, PEPCK , phosphoenolpyruvate carboxykinase, phosphoenolpyruvate carboxykinase
GTPの加水分解エネルギーを利用し、オキサロ酢酸を脱炭酸してホスホエノールピルビン酸を合成する酵素で、解糖の逆反応を行い糖新生に関与する。
英訳・(英)同義/類義語：carboxykinase, PEPCK , phosphoenolpyruvate carboxykinase, phosphoenolpyruvate carboxykinase
GTPの加水分解エネルギーを利用し、オキサロ酢酸を脱炭酸してホスホエノールピルビン酸を合成する酵素で、解糖の逆反応を行い糖新生に関与する。
ホスホエノールピルビン酸カルボキシキナーゼ
(Pepck から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/04/21 17:56 UTC 版)
ホスホエノールピルビン酸カルボキシキナーゼ（英: phosphoenolpyruvate carboxykinase、略称: PEPCK）はリアーゼファミリーに属する酵素で、糖新生の代謝経路に利用される。PEPCKはオキサロ酢酸をホスホエノールピルビン酸と二酸化炭素に変換する[1][2][3]。
- ^ a b “Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient availability”. J. Biol. Chem. 289 (32): 22090–102. (August 2014). doi:10.1074/jbc.M114.566927. PMC 4139223. PMID 24973213.
- ^ a b “PEPCK-M expression in mouse liver potentiates, not replaces, PEPCK-C mediated gluconeogenesis”. J. Hepatol. 59 (1): 105–13. (July 2013). doi:10.1016/j.jhep.2013.02.020. PMC 3910155. PMID 23466304.
- ^ a b “Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-C”. Critical Reviews in Biochemistry and Molecular Biology 40 (3): 129–54. (2005). doi:10.1080/10409230590935479. PMID 15917397.
- ^ a b c “Structural insights into the mechanism of PEPCK catalysis”. Biochemistry 45 (27): 8254–63. (July 2006). doi:10.1021/bi060269g. PMID 16819824.
- ^ a b “The phosphoenolpyruvate carboxykinase also catalyzes C3 carboxylation at the interface of glycolysis and the TCA cycle of Bacillus subtilis”. Metabolic Engineering 6 (4): 277–84. (October 2004). doi:10.1016/j.ymben.2004.03.001. PMID 15491857.
- ^ a b “Structure/function studies of phosphoryl transfer by phosphoenolpyruvate carboxykinase”. Biochimica et Biophysica Acta 1697 (1–2): 271–8. (March 2004). doi:10.1016/j.bbapap.2003.11.030. PMID 15023367.
- ^ “Crystal structure of the dimeric phosphoenolpyruvate carboxykinase (PEPCK) from Trypanosoma cruzi at 2 A resolution”. Journal of Molecular Biology 313 (5): 1059–72. (November 2001). doi:10.1006/jmbi.2001.5093. PMID 11700062.
- ^ Valera, A.; Pujol, A.; Pelegrin, M.; Bosch, F. (1994-09-13). “Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus”. Proceedings of the National Academy of Sciences of the United States of America 91 (19): 9151–9154. doi:10.1073/pnas.91.19.9151. ISSN 0027-8424. PMC PMC44765. PMID 8090784.
- ^ a b “Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver”. Cell Metabolism 5 (4): 313–20. (April 2007). doi:10.1016/j.cmet.2007.03.004. PMC 2680089. PMID 17403375.
- ^ Nash JT; Szabo DT; Carey GB (2012). “Polybrominated diphenyl ethers alter hepatic phosphoenolpyruvate carboxykinase enzyme kinetics in male Wistar rats: implications for lipid and glucose metabolism.”. Journal of Toxicological and Environmental Health Part A 76 (2): 142–56. doi:10.1080/15287394.2012.738457. PMID 23294302.
- ^ Hanson, Richard W.; Hakimi, Parvin (2008-06). “Born to run; the story of the PEPCK-Cmus mouse”. Biochimie 90 (6): 838–842. doi:10.1016/j.biochi.2008.03.009. ISSN 0300-9084. PMC 2491496. PMID 18394430.
- ^ Kanai R, Edwards, GE (1999). “3. The Biochemistry of C4 Photosynthesis”. C4 Plant Biology. pp. 43–87. ISBN 978-0-12-614440-6
- ^ “Patterns of carbon partitioning in leaves of Crassulacean acid metabolism species during deacidification”. Plant Physiol. 112 (1): 393–399. (1996). doi:10.1104/pp.112.1.393. PMC 157961. PMID 12226397.
- ^ Voznesenskaya E.V.; Franceschi V.R.; Chuong S.D.; Edwards G.E. (2006). “Functional characterization of phosphoenolpyruvate carboxykinase-type C4 leaf anatomy: immuno-cytochemical and ultrastructural analyses”. Annals of Botany 98 (1): 77–91. doi:10.1093/aob/mcl096. PMC 2803547. PMID 16704997.
- ^ a b c “Phosphoenolpyruvate carboxykinase in cucumber plants is increased both by ammonium and by acidification, and is present in the phloem”. Planta 219 (1): 48–58. (May 2004). doi:10.1007/s00425-004-1220-y. PMID 14991407.
- ^ a b “Expression, purification, and characterization of a bacterial GTP-dependent PEP carboxykinase”. Protein Expression and Purification 31 (2): 298–304. (October 2003). doi:10.1016/S1046-5928(03)00189-X. PMID 14550651.
- ^ “The phosphoenolpyruvate carboxykinase of Mycobacterium tuberculosis induces strong cell-mediated immune responses in mice”. Molecular and Cellular Biochemistry 288 (1–2): 65–71. (August 2006). doi:10.1007/s11010-006-9119-5. PMID 16691317.
- ^ “PCK2 activation mediates an adaptive response to glucose depletion in lung cancer”. Oncogene 34 (8): 1044–1050. (March 2014). doi:10.1038/onc.2014.47. PMID 24632615.
- ^ a b “Identification of a sequence in the PEPCK-C gene that mediates a negative effect of insulin on transcription”. Science 249 (4968): 533–7. (August 1990). doi:10.1126/science.2166335. PMID 2166335.
- ^ “The role of glycolysis and gluconeogenesis in the cytoprotection of neuroblastoma cells against 1-methyl 4-phenylpyridinium ion toxicity”. Neurotoxicology 24 (1): 137–47. (January 2003). doi:10.1016/S0161-813X(02)00110-9. PMID 12564389.
- ^ Walter F. Boron (2005). Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. ISBN 978-1-4160-2328-9 Page 858
[続きの解説]
「ホスホエノールピルビン酸カルボキシキナーゼ」の続きの解説一覧
- 1 ホスホエノールピルビン酸カルボキシキナーゼとは
- 2 ホスホエノールピルビン酸カルボキシキナーゼの概要
- 3 機能
- 4 臨床的意義
- 5 外部リンク
- Pepckのページへのリンク
