Mef2
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/03/20 10:05 UTC 版)
Mef2（myocyte enhancer factor 2）は、遺伝子発現の制御を通じて細胞分化の調節因子として機能し、胚発生に重要な役割を果たす転写因子ファミリーである[1]。成体では、Mef2タンパク質は一部の組織でストレス応答を媒介する[1]。Mef2タンパク質には、MADSボックスとMef2 DNA結合ドメインが存在する。
- ^ a b c “MEF2: a central regulator of diverse developmental programs”. Development 134 (23): 4131–40. (December 2007). doi:10.1242/dev.008367. PMID 17959722.
- ^ “A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes”. Mol. Cell. Biol. 9 (11): 5022–33. (1 November 1989). doi:10.1128/MCB.9.11.5022. PMC 363654. PMID 2601707.
- ^ “Human SRF-related proteins: DNA-binding properties and potential regulatory targets”. Genes Dev. 5 (12a): 2327–41. (1991). doi:10.1101/gad.5.12a.2327. PMID 1748287.
- ^ “MEF2: a calcium-dependent regulator of cell division, differentiation and death”. Trends Biochem. Sci. 27 (1): 40–7. (2002). doi:10.1016/S0968-0004(01)02031-X. PMID 11796223.
- ^ “Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins”. Annu Rev Cell Dev Biol 14: 167–96. (1998). doi:10.1146/annurev.cellbio.14.1.167. PMID 9891782.
- ^ “Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors”. Proc Natl Acad Sci USA 93 (18): 9366–73. (1996). Bibcode: 1996PNAS...93.9366M. doi:10.1073/pnas.93.18.9366. PMC 38433. PMID 8790335.
- ^ “The nuclear localization domain of the Mef2 family of transcription factors shows member-specific features and mediates the nuclear import of histone deacetylase 4”. J Cell Sci 114 (Pt 24): 4477–83. (2001). doi:10.1242/jcs.114.24.4477. PMID 11792813.
- ^ Yu YT (1996). “Distinct domains of myocyte enhancer binding factor-2A determining nuclear localization and cell type-specific transcriptional activity”. J Biol Chem 271 (40): 24675–83. doi:10.1016/S0021-9258(18)40058-0. PMID 8798735.
- ^ “D-MEF2: a MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesis”. Proc. Natl. Acad. Sci. U.S.A. 91 (12): 5662–6. (June 1994). Bibcode: 1994PNAS...91.5662L. doi:10.1073/pnas.91.12.5662. PMC 44056. PMID 8202544.
- ^ “Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins”. Cell 83 (7): 1125–36. (December 1995). doi:10.1016/0092-8674(95)90139-6. PMID 8548800.
- ^ “The Mef2c gene is a direct transcriptional target of myogenic bHLH and MEF2 proteins during skeletal muscle development”. Development 128 (22): 4623–33. (November 2001). doi:10.1242/dev.128.22.4623. PMID 11714687.
- ^ a b “The transcription factor MEF2C is required for craniofacial development”. Dev. Cell 12 (4): 645–52. (April 2007). doi:10.1016/j.devcel.2007.03.007. PMC 1920108. PMID 17420000.
- ^ a b “mef2ca is required in cranial neural crest to effect Endothelin1 signaling in zebrafish”. Dev. Biol. 308 (1): 144–57. (August 2007). doi:10.1016/j.ydbio.2007.05.018. PMC 2148033. PMID 17574232.
- ^ “Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy”. Cell 110 (4): 479–88. (August 2002). doi:10.1016/S0092-8674(02)00861-9. PMC 4459650. PMID 12202037.
- ^ “Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers”. J. Clin. Invest. 117 (9): 2459–67. (September 2007). doi:10.1172/JCI31960. PMC 1957540. PMID 17786239.
- ^ a b “Cooperative activation of cardiac transcription through myocardin bridging of paired MEF2 sites”. Development 144 (7): 1234–1241. (2017). doi:10.1242/dev.138487. PMC 5399617. PMID 28351867.
- ^ a b Barnes, Ralston M.; Harris, Ian S.; Jaehnig, Eric J.; Sauls, Kimberly; Sinha, Tanvi; Rojas, Anabel; Schachterle, William; McCulley, David J. et al. (2016-03-01). “MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1”. Development (Cambridge, England) 143 (5): 774–779. doi:10.1242/dev.126383. ISSN 1477-9129. PMC 4813332. PMID 26811383.
- ^ “The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field”. Developmental Biology 287 (1): 134–145. (2005). doi:10.1016/j.ydbio.2005.08.041. PMID 16188249.
- ^ “MEF2 transcription factors are key regulators of sprouting angiogenesis”. Genes Dev 30 (20): 2297–2309. (2016). doi:10.1101/gad.290619.116. PMC 5110996. PMID 27898394.
- ^ Black, Brian L.; Cripps, Richard M. (2010) (英語), Myocyte Enhancer Factor 2 Transcription Factors in Heart Development and Disease, Elsevier, pp. 673–699, doi:10.1016/b978-0-12-381332-9.00030-x, ISBN 978-0-12-381332-9 2022年3月20日閲覧。
- ^ Karamboulas, Christina; Dakubo, Gabriel D.; Liu, Jun; De Repentigny, Yves; Yutzey, Katherine; Wallace, Valerie A.; Kothary, Rashmi; Skerjanc, Ilona S. (2006-10-15). “Disruption of MEF2 activity in cardiomyoblasts inhibits cardiomyogenesis”. Journal of Cell Science 119 (Pt 20): 4315–4321. doi:10.1242/jcs.03186. ISSN 0021-9533. PMID 17003108.
- ^ a b c Chen, Xiao; Gao, Bing; Ponnusamy, Murugavel; Lin, Zhijuan; Liu, Jia (2017-12-19). “MEF2 signaling and human diseases”. Oncotarget 8 (67): 112152–112165. doi:10.18632/oncotarget.22899. ISSN 1949-2553. PMC 5762387. PMID 29340119.
[続きの解説]
「Mef2」の続きの解説一覧
- 1 Mef2とは
- 2 Mef2の概要
- 3 ノックアウト研究
- 4 外部リンク
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