児玉龍彦

ウィキペディア

索引トップ用語の索引ランキングカテゴリー

出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/12/20 03:58 UTC 版)

略歴

1953年（昭和28年）：東京都生まれ。
- 東京教育大学附属駒場中学校・高等学校を卒業して、東京大学医学部に入学。
1977年（昭和52年）：東京大学医学部卒業
- 同年6月：東京大学医学部附属病院医師
1984年（昭和59年）4月：医学博士（東京大学）
1985年（昭和60年）5月：マサチューセッツ工科大学研究員
1989年（平成元年）4月：東京大学医学部第三内科助手
1996年（平成8年）4月：東京大学先端科学技術研究センター教授
2002年（平成14年）4月：東京大学先端科学技術研究センター特任教授
2004年（平成16年）5月：東京大学先端科学技術研究センター基金教授（～2018年3月）^[9]
2011年（平成23年）4月：東京大学アイソトープ総合センター長(〜2017年3月）^[26]
2018年（平成30年）6月：東京大学名誉教授^[9]、東京大学先端科学技術研究センター　がん・代謝プロジェクトリーダー^[3]

著書・論文

著書

児玉龍彦、高橋潔、渋谷正史『血管生物学』講談社（原著1997年5月23日）。ISBN 978-4-06-153652-4。
児玉龍彦、浜窪隆雄『考える血管』講談社〈ブルーバックス〉（原著1997年6月20日）。ISBN 978-4062571760。
金子勝、児玉龍彦『逆システム学 -市場と生命のしくみを解き明かす』岩波書店〈岩波新書〉（原著2004年1月20日）。ISBN 978-4004308751。
児玉龍彦、仁科博道『システム生物医学入門』羊土社（原著2005年6月1日）。ISBN 978-4897064826。
金子勝、児玉龍彦『新興衰退国ニッポン』講談社〈現代プレミアブック〉（原著2010年6月12日）。ISBN 978-4062950589。
児玉龍彦『内部被曝の真実』幻冬舎〈幻冬舎新書〉（原著2011年9月8日）。ISBN 978-4344982291。
児玉龍彦、金子勝『放射能から子どもの未来を守る』ディスカヴァー・トゥエンティワン〈ディスカヴァー携書〉（原著2012年1月21日）。ISBN 978-4799310854。
児玉龍彦『放射能は取り除ける - 本当に役立つ除染の科学』幻冬舎〈幻冬舎新書〉（原著2013年7月28日）。ISBN 978-4344983106。
金子勝、児玉龍彦『日本病 -長期衰退のダイナミクス』岩波書店〈岩波新書〉（原著2016年1月21日）。ISBN 978-4004315834。
金子勝、児玉龍彦『現代カタストロフ論: 経済と生命の周期を解き明かす』岩波書店〈岩波新書〉（原著2022年12月22日）。ISBN 978-4004319535。

論文

筆頭著者、共著、最終責任著者含めて英文原著250報以上

Siwi levels reversibly regulate secondary piRISC biogenesis by affecting Ago3 body morphology in Bombyx mori. Nishida KM, Sakakibara K, Sumiyoshi T, Yamazaki H, Mannen T, Kawamura T, Kodama T, Siomi MC. EMBO J. 2020 Sep 11:e105130. https://doi.org/10.15252/embj.2020105130
Cupid and Psyche system for the diagnosis and treatment of advanced cancer. Sugiyama A, Kawamura T, Tanaka T, Doi H, Yamashita T, Shinoda K, Fujitani H, Yamatsugu K, Shimizu Y, Tatsumi T, Takahashi K, Kanai M, Mizohata E, Kawato T, Doi T, Inoue T, Kodama T. Proc Jpn Acad Ser B Phys Biol Sci. 2019;95(10):602-611. https://doi.org/10.2183/pjab.95.041
Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2. Osawa T, Shimamura T, Saito K, Hasegawa Y, Ishii N, Nishida M, Ando R, Kondo A, Anwar M, Tsuchida R, Hino S, Sakamoto A, Igarashi K, Saitoh K, Kato K, Endo K, Yamano S, Kanki Y, Matsumura Y, Minami T, Tanaka T, Anai M, Wada Y, Wanibuchi H, Hayashi M, Hamada A, Yoshida M, Yachida S, Nakao M, Sakai J, Aburatani H, Shibuya M, Hanada K, Miyano S, Soga T, Kodama T. Cell Rep. 2019 Oct 1;29(1):89-103. https://doi.org/10.1016/j.celrep.2019.08.087
Hierarchical roles of mitochondrial Papi and Zucchini in Bombyx germline piRNA biogenesis. Nishida KM, Sakakibara K, Iwasaki YW, Yamada H, Murakami R, Murota Y, Kawamura T, Kodama T, Siomi H, Siomi MC. Nature. 2018 Mar 8;555(7695):260-264. https://doi.org/10.1038/nature25788
MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1. Shichita T, Ito M, Morita R, Komai K, Noguchi Y, Ooboshi H, Koshida R, Takahashi S, Kodama T, Yoshimura A. Nat Med. 2017 Jun;23(6):723-732. doi: 10.1038/nm.4312. Epub 2017 Apr 10.
Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression. Kondo A, Yamamoto S, Nakaki R, Shimamura T, Hamakubo T, Sakai J, Kodama T, Yoshida T, Aburatani H, Osawa T. Cell Rep. 2017 Feb 28;18(9):2228-2242. doi: 10.1016/j.celrep.2017.02.006.
Effects of K-877, a novel selective PPARα modulator (SPPARMα), in dyslipidaemic patients: A randomized, double blind, active- and placebo-controlled, phase 2 trial. Ishibashi S, Yamashita S, Arai H, Araki E, Yokote K, Suganami H, Fruchart JC, Kodama T; K-877-04 Study Group. Atherosclerosis. 2016 Jun;249:36-43.
H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation. Matsumura Y, Nakaki R, Inagaki T, Yoshida A, Kano Y, Kimura H, Tanaka T, Tsutsumi S, Nakao M, Doi T, Fukami K, Osborne TF, Kodama T, Aburatani H, Sakai J. Mol Cell. 2015 Nov 19;60(4):584-96.
Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance. Takaba H, Morishita Y, Tomofuji Y, Danks L, Nitta T, Komatsu N, Kodama T, Takayanagi H. Cell. 2015 Nov 5;163(4):975-87.
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis. Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J. Nat Commun. 2015 May 7;6:7052.

Nishiyama A, Yamaguchi L, Sharif J, Johmura Y, Kawamura T, Nakanishi K, Shimamura S, Arita K, Kodama T, Ishikawa F, Koseki H, Nakanishi M. Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication. Nature. 2013 Oct 10;502(7470):249-53.
Hayashi M, Nakashima T, Taniguchi M, Kodama T, Kumanogoh A, Takayanagi H. Osteoprotection by semaphorin 3A. Nature. 2012 May 3;485(7396):69-74.
Osawa T, Muramatsu M, Wang F, Tsuchida R, Kodama T, Minami T, Shibuya M. Increased expression of histone demethylase JHDM1D under nutrient starvation suppresses tumor growth via down-regulating angiogenesis. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20725-9.
Fujita K, Iwasaki M, Ochi H, Fukuda T, Ma C, Miyamoto T, Takitani K, Negishi-Koga T, Sunamura S, Kodama T, Takayanagi H, Tamai H, Kato S, Arai H, Shinomiya K, Itoh H, Okawa A, Takeda S. Vitamin E decreases bone mass by stimulating osteoclast fusion. Nat Med. 2012 Mar 4;18(4):589-94.
Negishi-Koga T, Shinohara M, Komatsu N, Bito H, Kodama T, Friedel RH, Takayanagi H. Suppression of bone formation by osteoclastic expression of semaphorin 4D. Nat Med. 2011 Oct 23;17(11):1473-80.
Nakashima T, Hayashi M, Fukunaga T, Kurata K, Oh-Hora M, Feng JQ, Bonewald LF, Kodama T, Wutz A, Wagner EF, Penninger JM, Takayanagi H. Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med. 2011 Sep 11;17(10):1231-4.
Nishikawa K, Nakashima T, Hayashi M, Fukunaga T, Kato S, Kodama T, Takahashi S, Calame K, Takayanagi H. Blimp1-mediated repression of negative regulators is required for osteoclast differentiation. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3117-22.
Yanai H, Ban T, Wang Z, Choi MK, Kawamura T, Negishi H, Nakasato M, Lu Y, Hangai S, Koshiba R, Savitsky D, Ronfani L, Akira S, Bianchi ME, Honda K, Tamura T, Kodama T, Taniguchi T. HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. Nature. 2009 Nov 5;462(7269):99-103.
Wada Y, Ohta Y, Xu M, Tsutsumi S, Minami T, Inoue K, Komura D, Kitakami J, Oshida N, Papantonis A, Izumi A, Kobayashi M, Meguro H, Kanki Y, Mimura I, Yamamoto K, Mataki C, Hamakubo T, Shirahige K, Aburatani H, Kimura H, Kodama T, Cook PR, Ihara S. A wave of nascent transcription on activated human genes. Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18357-61.
Okamura M, Kudo H, Wakabayashi K, Tanaka T, Nonaka A, Uchida A, Tsutsumi S, Sakakibara I, Naito M, Osborne TF, Hamakubo T, Ito S, Aburatani H, Yanagisawa M, Kodama T, Sakai J. COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5819-24.
Fukuhara S, Sako K, Minami T, Noda K, Kim HZ, Kodama T, Shibuya M, Takakura N, Koh GY, Mochizuki N. Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. Nat Cell Biol. 2008 May;10(5):513-26.
Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, Ban T, Lu Y, Miyagishi M, Kodama T, Honda K, Ohba Y, Taniguchi T. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature. 2007 Jul 26;448(7152):501-5. Epub 2007 Jul 8.
Ochi S, Shinohara M, Sato K, Gober HJ, Koga T, Kodama T, Takai T, Miyasaka N, Takayanagi H. Pathological role of osteoclast costimulation in arthritis-induced bone loss. Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11394-9. Epub 2007 Jun 25.
Sato K, Suematsu A, Nakashima T, Takemoto-Kimura S, Aoki K, Morishita Y, Asahara H, Ohya K, Yamaguchi A, Takai T, Kodama T, Chatila TA, Bito H, Takayanagi H. Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Med. 2006 Dec;12(12):1410-6. Epub 2006 Nov 26.
Horiuchi K, Umetani M, Minami T, Okayama H, Takada S, Yamamoto M, Aburatani H, Reid PC, Housman DE, Hamakubo T, Kodama T. Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17278-83. Epub 2006 Nov 6.
Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature. 2006 Jan 26;439(7075):484-9. Epub 2006 Jan 8.
You LR, Takamoto N, Yu CT, Tanaka T, Kodama T, Demayo FJ, Tsai SY, Tsai MJ. Mouse lacking COUP-TFII as an animal model of Bochdalek-type congenital diaphragmatic hernia. Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16351-6. Epub 2005 Oct 26.
Koga T, Matsui Y, Asagiri M, Kodama T, de Crombrugghe B, Nakashima K, Takayanagi H. "NFAT and Osterix cooperatively regulate bone formation" Nat Med. 2005 Jul 24; [Epub ahead of print]
Koga T, Inui M, Inoue K, Kin S, Suematsu A, Kobayashi E, Iwata T, Ohnishi H, Matozaki T, Kodama T, Tniguchi T, Takayanagi H, Takai T. "ITAM-mediated costimulatory signals cooperate with RANKL for bone homeostasis" Nature 2004 428(6984):758-63.
Tanaka T, Yamamoto J, Iwasaki S, Asaba H, Hamura H, Ikeda Y, Watanabe M, Magoori K, Ioka RX, Tachibana K, Watanabe Y, Uchiyama Y, Sumi K, Iguchi H, Ito S, Doi T, Hamakubo T, Naito M, Auwerx J, Yanagisawa M, Kodama T, Sakai J. "Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome" Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26): 15924-9.
Terauchi Y, Kodamam T, et al. "Increased insulin sensitivity and hypoglycemia in mice lacking the p85a subunit of phophoinositide 3 kinase" Nature Genetics, 1999, 21. 230-235
Cynshi O, Kawabe Y, Suzuki T, Takashima Y, Kaise H, Nakamura M, Ohba Y, Kato Y, Tamura K, Hayasaka A, Higashida A, Sakaguchi H, Takeya M, Takahashi K, Inoue K, Noguchi N, Niki E and Kodama T. "Antiatherogenic effects of the antioxidant BO-653 in three different animal model" Proc. Natl. Acad. Sci USA 1998, 95, 10123-10128
Suzuki H, Kurihara Y, Takeya M, Kamada N, Kataoka M, Jishage K, Ueda O, Sakaguchi H, Higashi T, Suzuki T, Takashima Y, Kawabe Y, Cynshi O, Wada Y, Honda M, Kurihara H, Aburatani H, Doi T, Matsumoto A, Azuma S, Noda T, Toyoda Y, Itakura H, Yazaki Y, Horiuchi S, Takahashi K, Kruijt J-K, van Berkel T-J-C, Steinbrecher U-P, Ishibashi S, maeda N, Gordon S & Kodama T. "Resistance to atherosclerosis and susceptibility to infection in scavenger receptor knockout mice" Nature, 1997, 386, 292-6
Kurihara, Y., Kurihara, H., Suzuki, H., Kodama, T., Maemura, K., Nagai, R., Oda, H., Kuwaki, T., Cao, W-H., Kamata, N., Jishage, K., Ouchi, Y., Azuma, S., Toyoda, Y., Ishikawa, T., Kumada, M.,& Yazaki, Y. (1994). "Disruption of mouse endothelin-1 gene results in lethality and craniofacial anomaly in homozygotes and elevated blood pressure in heterozygotes" Nature, 368, 703-710
Matsumoto, A., Naito, M., Itakura, H., Ikemoto, S., Asaoka, H., Hayakawa, I., Kanamori, H., Aburatani, H., Takaku, F., Suzuki, H. Kobari, Y., Miyai, T., Takahashi, K., Cohen, E.H., Wydro, R., Housman, D.E., & Kodama, T.(1990). "Human macrophage scavenger receptors: Primary structure, expression, and localization in atherosclerotic lesions" Proc Natl Acad Sci U S A, 87(23), 9133-9137.
Kodama, T., Freeman, M., Rohrer, L., Zabrecky, J., Matsudaira, P., & Krieger, M. (1990). "Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils" Nature, 343(6258), 531-535.
Rohrer, L., Freeman, M., Kodama, T., Penman, M., & Krieger, M. (1990). "Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II" Nature, 343(6258), 570-572.
Kodama, T., Reddy, P., Kishimoto, C., & Krieger, M. (1988). "Purification and characterization of a bovine acetyl low density lipoprotein receptor" Proc Natl Acad Sci U S A, 85(23), 9238-9242.
Okazaki, M., Hara, I., Tanaka, A., Kodama, T., & Yokoyama, S.(1981). "Decreased serum HDL, cholesterol levels in cirrhosis of the liver" N Engl J Med, 304, 1608.