パイオン【pion】
Pion
γ-セクレターゼ活性化タンパク質
(pion から転送)
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2023/03/05 06:56 UTC 版)
γ-セクレターゼ活性化タンパク質(英: gamma-secretase activating protein、GSAP)もしくはPION(pigeon homolog)は、ヒトではGSAP遺伝子にコードされるタンパク質である[5]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000186088 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039934 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “GSAP gamma-secretase activating protein [Homo sapiens (human) - Gene - NCBI]”. www.ncbi.nlm.nih.gov. 2023年2月26日閲覧。
- ^ “Human hg38 chr7:77,310,751-77,416,349 UCSC Genome Browser v444”. genome.ucsc.edu. 2023年3月5日閲覧。
- ^ HomoloGene: 45504
- ^ UniProt: A4D1B5
- ^ a b c d e “Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease”. Nature 467 (7311): 95–8. (September 2010). Bibcode: 2010Natur.467...95H. doi:10.1038/nature09325. PMC 2936959. PMID 20811458 .
- Gina Kolata (2010年9月1日). “Finding Suggests New Aim for Alzheimer's Drugs”. The New York Times
- ^ “Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux”. The Journal of Pharmacology and Experimental Therapeutics 304 (3): 1085–92. (March 2003). doi:10.1124/jpet.102.045260. PMID 12604685.
- ^ “Alzheimer's disease: Selectively tuning gamma-secretase”. Nature 467 (7311): 36–7. (September 2010). Bibcode: 2010Natur.467...36S. doi:10.1038/467036a. PMID 20811445.
- ^ “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proceedings of the National Academy of Sciences of the United States of America 99 (26): 16899–903. (December 2002). Bibcode: 2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932 .
- ^ “Gleevec inhibits beta-amyloid production but not Notch cleavage”. Proceedings of the National Academy of Sciences of the United States of America 100 (21): 12444–9. (October 2003). Bibcode: 2003PNAS..10012444N. doi:10.1073/pnas.1534745100. PMC 218777. PMID 14523244 .
- 1 γ-セクレターゼ活性化タンパク質とは
- 2 γ-セクレターゼ活性化タンパク質の概要
- 3 機能
- 4 関連文献
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