ノイラミニダーゼ1
(Sialidase-1 から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/12/03 05:38 UTC 版)
NEU1としても知られるシアリダーゼ1（リソソームシアリダーゼ）ノイラミニダーゼ1 (ノイラミニダーゼワン、Neuraminidase 1、EC3.2.1.18）は、シアル酸残基と他の分子とのグリコシド結合を加水分解するエキソグリコシダーゼである。哺乳類細胞のリソソーム内にカテプシンAと複合体を形成して存在する。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000227129、ENSG00000184494、ENSG00000223957、ENSG00000234846、ENSG00000204386、ENSG00000234343、ENSG00000227315、ENSG00000228691 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007038 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Entrez Gene: NEU1 sialidase 1 (lysosomal sialidase)”. 2017年9月5日閲覧。
- ^ “Cloning, expression and chromosomal mapping of human lysosomal sialidase and characterization of mutations in sialidosis”. Nat. Genet. 15 (3): 316–20. (March 1997). doi:10.1038/ng0397-316. PMID 9054950.
- ^ Tsukimoto, Jun; Takeuchi, Yoshie; Horii, Yuto; Iniwa, Toshiki; Fukushi, Yuri; Nishioka, So-Ichiro; Itoh, Kohji (2022-01-17). “In Cellulo Crystallization of Human Neuraminidase 1 and Biological Roles of N-Glycans”. ACS applied bio materials 5 (1): 205–213. doi:10.1021/acsabm.1c01043. ISSN 2576-6422. PMID 35014832.
- ^ Koiwai, Kotaro; Tsukimoto, Jun; Higashi, Tetsuya; Mafuné, Fumitaka; Miyajima, Ken; Nakane, Takanori; Matsugaki, Naohiro; Kato, Ryuichi et al. (2019-11-18). “Improvement of Production and Isolation of Human Neuraminidase-1 in Cellulo Crystals”. ACS applied bio materials 2 (11): 4941–4952. doi:10.1021/acsabm.9b00686. ISSN 2576-6422. PMID 35021494.
- ^ Oheda, Yukako; Kotani, Masaharu; Murata, Mai; Sakuraba, Hitoshi; Kadota, Yoshito; Tatano, Yutaka; Kuwahara, Jun; Itoh, Kohji (2006-04). “Elimination of abnormal sialylglycoproteins in fibroblasts with sialidosis and galactosialidosis by normal gene transfer and enzyme replacement”. Glycobiology 16 (4): 271–280. doi:10.1093/glycob/cwj069. ISSN 0959-6658. PMID 16361247.
- ^ Naganawa, Y.; Itoh, K.; Shimmoto, M.; Takiguchi, K.; Doi, H.; Nishizawa, Y.; Kobayashi, T.; Kamei, S. et al. (2000). “Molecular and structural studies of Japanese patients with sialidosis type 1”. Journal of Human Genetics 45 (4): 241–249. doi:10.1007/s100380070034. ISSN 1434-5161. PMID 10944856.
- ^ Itoh, K.; Miharu, N.; Ohama, K.; Mizoguchi, N.; Sakura, N.; Sakuraba, H. (1997-10-31). “Fetal diagnosis of galactosialidosis (protective protein/cathepsin A deficiency)”. Clinica Chimica Acta; International Journal of Clinical Chemistry 266 (2): 75–82. doi:10.1016/s0009-8981(97)00141-1. ISSN 0009-8981. PMID 9437536.
- ^ Nakajima, Hideki; Ueno, Miki; Adachi, Kaori; Nanba, Eiji; Narita, Aya; Tsukimoto, Jun; Itoh, Kohji; Kawakami, Atushi (2019). “A new heterozygous compound mutation in the CTSA gene in galactosialidosis”. Human Genome Variation 6: 22. doi:10.1038/s41439-019-0054-x. ISSN 2054-345X. PMC 6486599. PMID 31044084.
- ^ Horii, Yuto; Iniwa, Toshiki; Onitsuka, Masayoshi; Tsukimoto, Jun; Tanaka, Yuki; Ike, Hironobu; Fukushi, Yuri; Ando, Haruna et al. (2022-06-09). “Reversal of neuroinflammation in novel GS model mice by single i.c.v. administration of CHO-derived rhCTSA precursor protein”. Molecular Therapy. Methods & Clinical Development 25: 297–310. doi:10.1016/j.omtm.2022.04.001. ISSN 2329-0501. PMC 9062439. PMID 35573044.
- ^ Bonten, Erik J.; Campos, Yvan; Zaitsev, Viateslav; Nourse, Amanda; Waddell, Brett; Lewis, William; Taylor, Garry; d'Azzo, Alessandra (2009-10-09). “Heterodimerization of the sialidase NEU1 with the chaperone protective protein/cathepsin A prevents its premature oligomerization”. The Journal of Biological Chemistry 284 (41): 28430–28441. doi:10.1074/jbc.M109.031419. ISSN 1083-351X. PMC 2788892. PMID 19666471.
[続きの解説]
「ノイラミニダーゼ1」の続きの解説一覧
- 1 ノイラミニダーゼ1とは
- 2 ノイラミニダーゼ1の概要
- 3 概要
- 4 参考文献
- ノイラミニダーゼ1のページへのリンク
