Phosphatidylserineとは? わかりやすく解説

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ホスファチジルセリン


ホスファチジルセリン

(Phosphatidylserine から転送)

出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2023/11/18 05:21 UTC 版)

ホスファチジルセリン(Phosphatidylserine、略称: Ptd-L-SerあるいはPS)は、リン脂質の成分であり、通常はフリッパーゼと呼ばれる酵素によって細胞膜の内葉(細胞質側)に留められている。細胞にアポトーシスが起こる時、ホスファチジルセリンは細胞膜の細胞質側にもはや制限されず、細胞の表面に露出するようになる[1]。後述される効用のためアメリカでは広くサプリメントとして普及している。


  1. ^ Verhoven, B; Schlegel, RA, Williamson, P (1995). “Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes”. The Journal of experimental medicine 182 (5): 1597–601. doi:10.1084/jem.182.5.1597. PMC 2192221. PMID 7595231. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192221/. 
  2. ^ Phosphatidylserine and related lipids
  3. ^ Phosphatidylcholine, structure, occurrence, biochemistry and analysis”. Lipidlibrary.aocs.org (2012年4月30日). 2012年8月6日閲覧。
  4. ^ Can phosphatidylserine improve memory and cognitive function in people with Alzheimer's disease?”. mayoclinic.com. 2013年3月17日閲覧。
  5. ^ Phosphatidylserine and Cognitive Dysfunction and Dementia (Qualified Health Claim: Final Decision Letter)”. Fda.gov. 2013年3月17日閲覧。
  6. ^ Blokland A, Honig W, Brouns F, Jolles J (October 1999). “Cognition-enhancing properties of subchronic phosphatidylserine (PS) treatment in middle-aged rats: comparison of bovine cortex PS with egg PS and soybean PS”. Nutrition 15 (10): 778–83. doi:10.1016/S0899-9007(99)00157-4. PMID 10501292. http://linkinghub.elsevier.com/retrieve/pii/S0899900799001574. 
  7. ^ Crook, T. H.; R. M. Klatz (ed) (1998). Treatment of Age-Related Cognitive Decline: Effects of Phosphatidylserine in Anti-Aging Medical Therapeutics. 2. Chicago: Health Quest Publications. pp. 20–29 
  8. ^ Phosphatidylserine and Cognitive Dysfunction and Dementia (Qualified Health Claim: Final Decision Letter)”. Fda.gov. 2012年8月6日閲覧。
  9. ^ a b Parker AG, Gordon J, Thornton A, Byars A, Lubker J, Bartlett M, Byrd M, Oliver J, Simbo S, Rasmussen C, Greenwood M, Kreider RB (October 2011). “The effects of IQPLUS Focus on cognitive function, mood and endocrine response before and following acute exercise”. International Society of Sports Nutrition 8 (1). http://www.jissn.com/content/8/1/16. 
  10. ^ Kingsley M, Wadsworth D, Kilduff LP, McEneny J, Benton D (August 2005). “Effects of phosphatidylserine on oxidative stress following intermittent running”. Med Sci Sports Exerc 37 (8): 1300–1306. PMID 16118575. 
  11. ^ Kingsley MI, Miller M, Kilduff LP, McEneny J, Benton D (January 2006). “Effects of phosphatidylserine on exercise capacity during cycling in active males”. Med Sci Sports Exerc 38 (1): 64–71. PMID 16394955. 
  12. ^ a b Jäger R, Purpura M, Geiss K-R, Weiß M, Baumeister J, Amatulli F, Schröder L, Herwegen H (December 2007). “The effect of phosphatidylserine on golf performance”. International Society of Sports Nutrition 4 (1). http://www.jissn.com/content/4/1/23. 
  13. ^ a b c Starks MA, Starks SL, Kingsley M, Purpura M, Jäger R (July 2008). “The effects of phosphatidylserine on endocrine response to moderate intensity exercise”. J Int Soc Sports Nutr 5. PMC 2503954. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503954/. 
  14. ^ a b Monteleone P, Maj M, Beinat L, Natale M, Kemali D (1992). “Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men”. Eur J Clin Pharmacol 42 (4): 385–388. PMID 1325348. 
  15. ^ Fernholz KM, Seifert JG, Bacharach DW, Burke ER, Gazal O (2000). “The Effects of Phosphatidyl Serine on Markers of Muscular Stress in Endurance Runners [abstract]”. Med Sci Sports Exerc 32 (4): S321. 
  16. ^ Fahey TD, Pearl MS (1998). “The Hormonal and Perceptive Effects of Phosphatidylserine Administration During Two Weeks of Weight Training-Induced Over-Training”. Biol Sport 15 (2). 
  17. ^ Benton D, Donohoe RT, Sillance B, Nabb S (2001). “The Influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor”. Nutr Neurosci 4 (3): 169–178. PMID 11842886. 
  18. ^ Hirayama S, Masuda Y, Rabeler R (September/October 2006). “Effect of phosphatidylserine administration on symptoms of attention-deficit/hyperactivity disorder in children”. Agro Food 17 (5): 32–36. http://www.lipamin-ps.com/upd/file/agro_16_20.pdf. 
  19. ^ Vaisman N, Kaysar N, Zaruk-Adasha Y, Pelled D, Brichon G, Zwingelstein G, Bodennec J (2008). “Correlation between changes in blood fatty acid composition and visual sustained attention performance in children with inattention: effect of dietary n-3 fatty acids containing phospholipids”. The American Journal of Clinical Nutrition 87 (5): 1170–1180. PMID 18469236. http://www.ajcn.org/cgi/content/abstract/87/5/1170. 
  20. ^ Hirayama S., Terasawa K., Rabeler R., Hirayama T., Inoue T., Tatsumi Y., Purpura M. & Jäger R. (2013). “The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial”. Human Nutrition and Dietetics. doi:10.1111/jhn.12090. PMID 23495677. 
  21. ^ Jorissen BL, Brouns F, Van Boxtel MP, Riedel WJ (October 2002). “Safety of soy-derived phosphatidylserine in elderly people”. Nutr Neurosci 5 (5): 337–343. doi:10.1080/1028415021000033802. PMID 12385596. 
  22. ^ Hoffmann PR, Kench JA, Vondracek A, et al. (February 2005). “Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo”. J. Immunol. 174 (3): 1393–404. PMID 15661897. http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=15661897. 
  23. ^ Carr DJ, Guarcello V, Blalock JE (September 1992). “Phosphatidylserine suppresses antigen-specific IgM production by mice orally administered sheep red blood cells”. Proc. Soc. Exp. Biol. Med. 200 (4): 548–54. PMID 1508948. 
  24. ^ Souci SW, Fachmann E, Kraut H (2008). Food Composition and Nutrition Tables. Medpharm Scientific Publishers Stuttgart 
  25. ^ C.R. Scholfield (October 1981). “Composition of Soybean Lecithin”. Journal of the American Oil Chemists' Society 58 (10): 890. http://fodmapliving.com/wp-content/uploads/2013/02/Composition-of-Soybean-Lecithin.pdf. 


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