ノビレチン
ノビレチン
(Nobiletin から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2020/06/18 01:18 UTC 版)
ノビレチン (Nobiletin) は、柑橘類の果皮等に多く含まれる有機化合物で、フラボンを骨格に持つポリメトキシフラボノイド（O-メチル化フラボノイド）の一種である。
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- ^ Minagawa A, Otani Y, Kubota T, Wada N, Furukawa T, Kumai K, Kameyama K, Okada Y, Fujii M, Yano M, Sato T, Ito A, Kitajima M (2001). “The citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID mice”. Jpn J Cancer Res 92 (12): 1322-1328. PMID 11749698.
- ^ Sato T, Koike L, Miyata Y, Hirata M, Mimaki Y, Sashida Y, Yano M, Ito A. (2002). “Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells”. Cancer Res 62 (4): 1025-1029. PMID 11861377.
- ^ Yoshimizu N, Otani Y, Saikawa Y, Kubota T, Yoshida M, Furukawa T, Kumai K, Kameyama K, Fujii M, Yano M, Sato T, Ito A, Kitajima M (2004). “Anti-tumour effects of nobiletin, a citrus flavonoid, on gastric cancer include: antiproliferative effects, induction of apoptosis and cell cycle deregulation”. Aliment Pharmacol Ther 1: 95-101. doi:10.1111/j.1365-2036.2004.02082.x. PMID 15298613.
- ^ Tanaka S, Sato T, Akimoto N, Yano M, Ito A (2004). “Prevention of UVB-induced photoinflammation and photoaging by a polymethoxy flavonoid, nobiletin, in human keratinocytes in vivo and in vitro”. Biochem Pharmacol 68: 433-439. doi:10.1016/j.bcp.2004.04.006. PMID 15242810.
- ^ Akachi T, Shiina Y, Ohishi Y, Kawaguchi T, Kawagishi H, Morita T, Mori M, Sugiyama K (2010). “Hepatoprotective effects of flavonoids from shekwasha (Citrus depressa) against D-galactosamine-induced liver injury in rats”. J Nutr Sci Vitaminol 56 (1): 60-67. doi:10.3177/jnsv.56.60. PMID 20354348.
- ^ Henrotin, Y.; C. Lambert; D. Couchourel; C. Ripoll; E. Chiotelli (January 2011). “Nutraceuticals: do they represent a new era in the management of osteoarthritis? – a narrative review from the lessons taken with five products”. Osteoarthritis and Cartilage 19 (1): 1–21. doi:10.1016/j.joca.2010.10.017. PMID 21035558 2011年12月27日閲覧。.
- ^ Matsuzaki K, Miyazaki K, Sakai S, Yawo H, Nakata N, Moriguchi S, Fukunaga K, Yokosuka A, Sashida Y, Mimaki Y, Yamakuni T, Ohizumi Y (2008). “Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus”. Eur J Pharmacol 578 (2-3): 194-200. doi:10.1016/j.ejphar.2007.09.028. PMID 17976577.
[続きの解説]
「ノビレチン」の続きの解説一覧
- 1 ノビレチンとは
- 2 ノビレチンの概要
- Nobiletinのページへのリンク
