グリピカン
(Glypican から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/09/27 10:11 UTC 版)
グリピカン（英: glypican）は、ヘパラン硫酸プロテオグリカンの主要な2つのファミリーのうちの1つを構成する。もう1つのファミリーはシンデカンである。哺乳類では6種類のグリピカンが同定されており、グリピカン1（GPC1）からグリピカン6（GPC6）と呼ばれている[1][2]。ショウジョウバエDrosophilaでは2種類（Dally、Dally-like）、Caenorhabditis elegansでは1種類のグリピカンが同定されている[3]。グリピカンは発生時の形態形成に重要な役割を果たしているようであり、Wnt[4][5][6]やHedgehogシグナル伝達経路の調節因子であることが示唆されている。また、FGFやBMPシグナル伝達の調節因子としても示唆されている[2]。
- ^ a b c d e “Glypican-3: a new target for cancer immunotherapy”. European Journal of Cancer 47 (3): 333–8. (February 2011). doi:10.1016/j.ejca.2010.10.024. PMC 3031711. PMID 21112773.
- ^ a b c d e f g h “Glypicans”. Genome Biology 9 (5): 224. (2008). doi:10.1186/gb-2008-9-5-224. PMC 2441458. PMID 18505598.
- ^ a b c d e f g “Developmental roles of the glypicans”. Seminars in Cell & Developmental Biology 12 (2): 117–25. (April 2001). doi:10.1006/scdb.2000.0240. PMID 11292377.
- ^ Gao, Wei; Ho, Mitchell (2011). “The role of glypican-3 in regulating Wnt in hepatocellular carcinomas”. Cancer Reports 1 (1): 14–19. PMC 3343874. PMID 22563565.
- ^ a b Gao, Wei; Xu, Yongmei; Liu, Jian; Ho, Mitchell (May 17, 2016). “Epitope mapping by a Wnt-blocking antibody: evidence of the Wnt binding domain in heparan sulfate”. Scientific Reports 6: 26245. Bibcode: 2016NatSR...626245G. doi:10.1038/srep26245. ISSN 2045-2322. PMC 4869111. PMID 27185050.
- ^ a b Li, Na; Wei, Liwen; Liu, Xiaoyu; Bai, Hongjun; Ye, Yvonne; Li, Dan; Li, Nan; Baxa, Ulrich et al. (October 2019). “A Frizzled-Like Cysteine-Rich Domain in Glypican-3 Mediates Wnt Binding and Regulates Hepatocellular Carcinoma Tumor Growth in Mice”. Hepatology 70 (4): 1231–1245. doi:10.1002/hep.30646. ISSN 1527-3350. PMC 6783318. PMID 30963603.
- ^ a b c “Glypicans: proteoglycans with a surprise”. The Journal of Clinical Investigation 108 (4): 497–501. (August 2001). doi:10.1172/JCI13712. PMC 209407. PMID 11518720.
- ^ a b c d “Glypicans in growth control and cancer”. Glycobiology 11 (3): 19R–23R. (March 2001). doi:10.1093/glycob/11.3.19r. PMID 11320054.
- ^ “Hox control of morphogen mobility and organ development through regulation of glypican expression”. Development 134 (2): 327–34. (January 2007). doi:10.1242/dev.02737. PMID 17166918.
- ^ “Cellular trafficking of the glypican Dally-like is required for full-strength Hedgehog signaling and wingless transcytosis”. Developmental Cell 14 (5): 712–25. (May 2008). doi:10.1016/j.devcel.2008.03.001. PMID 18477454.
- ^ a b “Glypican-1 is overexpressed in human breast cancer and modulates the mitogenic effects of multiple heparin-binding growth factors in breast cancer cells”. Cancer Research 61 (14): 5562–9. (July 2001). PMID 11454708.
- ^ “Glypican-1 is frequently overexpressed in human gliomas and enhances FGF-2 signaling in glioma cells”. The American Journal of Pathology 168 (6): 2014–26. (June 2006). doi:10.2353/ajpath.2006.050800. PMC 1606624. PMID 16723715.
- ^ “Biology of hepatocellular carcinoma”. Annals of Surgical Oncology 15 (4): 962–71. (April 2008). doi:10.1245/s10434-007-9730-z. PMID 18236113.
- ^ a b c d e “Therapeutically targeting glypican-2 via single-domain antibody-based chimeric antigen receptors and immunotoxins in neuroblastoma”. Proceedings of the National Academy of Sciences of the United States of America 114 (32): E6623–E6631. (August 2017). doi:10.1073/pnas.1706055114. PMC 5559039. PMID 28739923.
- ^ “Evidence from human and zebrafish that GPC1 is a biliary atresia susceptibility gene”. Gastroenterology 144 (5): 1107–1115.e3. (May 2013). doi:10.1053/j.gastro.2013.01.022. PMC 3736559. PMID 23336978.
- ^ Pan, Jiajia; Ho, Mitchell (2021-11-01). “Role of glypican-1 in regulating multiple cellular signaling pathways”. American Journal of Physiology. Cell Physiology 321 (5): C846–C858. doi:10.1152/ajpcell.00290.2021. ISSN 1522-1563. PMC 8616591. PMID 34550795.
- ^ Pan, Jiajia; Li, Nan; Renn, Alex; Zhu, Hu; Chen, Lu; Shen, Min; Hall, Matthew D.; Qian, Min et al. (2022-06-01). “GPC1-Targeted Immunotoxins Inhibit Pancreatic Tumor Growth in Mice via Depletion of Short-lived GPC1 and Downregulation of Wnt Signaling”. Molecular Cancer Therapeutics 21 (6): 960–973. doi:10.1158/1535-7163.MCT-21-0778. ISSN 1538-8514. PMC 9167738. PMID 35312769.
- ^ a b c “Frequent silencing of the GPC3 gene in ovarian cancer cell lines”. Cancer Research 59 (4): 807–10. (February 1999). PMID 10029067.
- ^ a b c “Expression of GPC3, an X-linked recessive overgrowth gene, is silenced in malignant mesothelioma”. Oncogene 19 (3): 410–6. (January 2000). doi:10.1038/sj.onc.1203322. PMID 10656689.
- ^ “Glypican-1 regulates anaphase promoting complex/cyclosome substrates and cell cycle progression in endothelial cells”. Molecular Biology of the Cell 19 (7): 2789–801. (July 2008). doi:10.1091/mbc.E07-10-1025. PMC 2441674. PMID 18417614.
- ^ a b “Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma”. Cancer Cell 32 (3): 295–309.e12. (September 2017). doi:10.1016/j.ccell.2017.08.003. PMC 5600520. PMID 28898695.
[続きの解説]
「グリピカン」の続きの解説一覧
- 1 グリピカンとは
- 2 グリピカンの概要
- 3 臨床的意義
- グリピカンのページへのリンク
