コレセプター
Coreceptor
【概要】 共同受容体。HIVが細胞に感染する時、細胞膜のCD4だけでは接着するだけで感染が成立しない。同時にCCR5やCXCR4というケモカイン受容体が必要である。これらを感染のためのコレセプターと呼んでいる。
【詳しく】 CCR5には遺伝的な多型がある。いくつかの欠損がある場合はHIVが侵入できないか、病気の進行が遅く、「生まれつきHIVに感染しにくい人がいる」ことがはっきりした。アジア人ではこの変異は少ないそうである。
共同受容体
コレセプター
(Co-receptor から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2024/05/11 03:00 UTC 版)
コレセプター（英: co-receptor）は、リガンド認識の促進や病原体の宿主細胞への進入などの生物学的過程の開始のため、主要な受容体（primary receptor、プライマリーレセプター）に加えてシグナル伝達分子が結合する細胞表面受容体である。共受容体、共同受容体、補助受容体などの語があてられる。
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[続きの解説]
「コレセプター」の続きの解説一覧
- 1 コレセプターとは
- 2 コレセプターの概要
- 3 臨床的意義
- 4 現在の研究領域
- 5 関連項目
- Co-receptorのページへのリンク
