核膜孔
(核孔 から転送)
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/09/25 03:51 UTC 版)
核膜孔（かくまくこう、英：Nuclear pore）とは、核の内外を連絡する穴である。真核生物の核膜の内膜と外膜が融合する場にあり、核と細胞質間の物質の移動はこの核膜孔を介して行われる。核膜孔には核膜孔複合体が位置し、これは8個のサブユニットが回転対称に配置された巨大なタンパク質複合体である。脊椎動物の細胞の核膜には約1000個の核膜孔複合体が存在するが、その数は細胞種や生活環の段階に依存して変動する[1]。
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- ^ Stewart, Murray (2007-3). “Molecular mechanism of the nuclear protein import cycle”. Nature Reviews. Molecular Cell Biology 8 (3): 195–208. doi:10.1038/nrm2114. ISSN 1471-0072. PMID 17287812.
- ^ Hutten, Saskia; Kehlenbach, Ralph H. (2007-4). “CRM1-mediated nuclear export: to the pore and beyond”. Trends in Cell Biology 17 (4): 193–201. doi:10.1016/j.tcb.2007.02.003. ISSN 1879-3088. PMID 17317185.
- ^ Okamura, Masumi; Inose, Haruko; Masuda, Seiji (2015-03-20). “RNA Export through the NPC in Eukaryotes”. Genes 6 (1): 124–149. doi:10.3390/genes6010124. ISSN 2073-4425. PMC PMCPMC4377836. PMID 25802992.
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- ^ “Steps of nuclear pore complex disassembly and reassembly during mitosis in early Drosophila embryos”. Journal of Cell Science 114 (Pt 20): 3607–18. (October 2001). PMID 11707513.
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- ^ Laurell, Eva; Beck, Katja; Krupina, Ksenia; Theerthagiri, Gandhi; Bodenmiller, Bernd; Horvath, Peter; Aebersold, Ruedi; Antonin, Wolfram et al. (2011-02-18). “Phosphorylation of Nup98 by multiple kinases is crucial for NPC disassembly during mitotic entry”. Cell 144 (4): 539–550. doi:10.1016/j.cell.2011.01.012. ISSN 1097-4172. PMID 21335236.
- ^ Markossian, Sarine; Suresh, Subbulakshmi; Osmani, Aysha H.; Osmani, Stephen A. (2015-02-15). “Nup2 requires a highly divergent partner, NupA, to fulfill functions at nuclear pore complexes and the mitotic chromatin region”. Molecular Biology of the Cell 26 (4): 605–621. doi:10.1091/mbc.E14-09-1359. ISSN 1059-1524. PMC 4325833. PMID 25540430.
- ^ De Souza, Colin P. C.; Osmani, Aysha H.; Hashmi, Shahr B.; Osmani, Stephen A. (2004). “Partial Nuclear Pore Complex Disassembly during Closed Mitosis in Aspergillus nidulans”. Current Biology 14 (22): 1973–1984. doi:10.1016/j.cub.2004.10.050. ISSN 0960-9822. PMID 15556859.
- ^ Souza, Colin P. C. De; Osmani, Stephen A. (2007-09-01). “Mitosis, Not Just Open or Closed”. Eukaryotic Cell 6 (9): 1521–1527. doi:10.1128/EC.00178-07. ISSN 1535-9778. PMC 2043359. PMID 17660363.
- ^ Asakawa, Haruhiko; Kojidani, Tomoko; Mori, Chie; Osakada, Hiroko; Sato, Mamiko; Ding, Da-Qiao; Hiraoka, Yasushi; Haraguchi, Tokuko (2010-11-09). “Virtual breakdown of the nuclear envelope in fission yeast meiosis”. Current biology: CB 20 (21): 1919–1925. doi:10.1016/j.cub.2010.09.070. ISSN 1879-0445. PMID 20970342.
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