ビダラビン
| 分子式： | C10H13N5O4 |
| その他の名称： | ビダラビン、CI-673、Vidarabine、9-β-D-Arabinofuranosyl-9H-purin-6-amine、アデニンアラビノシド、アラビノシルアデニン、β-D-アラビノシルアデニン、9-アラビノシルアデニン、Arabinosyladenine、Ara-A、Adenine arabinoside、NSC-404241、9-Arabinosyladenine、β-D-Arabinosyladenine、9-(β-D-Arabinofuranosyl)-6-amino-9H-purine、アラビノフラノシルアデニン、β-D-アラビノフラノシドアデニン、9-β-D-アラビノフラノシルアデニン、9-β-D-Arabinofuranosyladenine、9-β-D-アラビノアデノシン、スポンゴアデノシン、アラアデノシン、β-Ara-A、9-β-D-Arabinoadenosine、Spongoadenosine、Araadenosine、β-D-Arabinofuranoside adenine、Vidarabin、Arabinofuranosyladenine、アデニン9-β-D-アラビノフラノシド、Adenine 9-β-D-arabinofuranoside、アラセナA、Aracena A、アラA、2'β-Hydroxy-2'-deoxyadenosine、9-β-D-Arabinofuranosyl-6-amino-9H-purine、6-Amino-9-β-D-arabinofuranosyl-9H-purine、6-Amino-9-β-(D-arabinofuranosyl)-9H-purine、9-(β-D-Arabinofuranosyl)-9H-purin-6-amine、アラエビン、Araebin、アラーゼ、Alase、アラセナ-A、Arasena-A、カサール、Casal、シオスナール、Siosnal、シルベラン、Silberan、ビフビン、Bifubine、ホスラビン、Hosrabine |
| 体系名： | 9-β-D-アラビノフラノシル-6-アミノ-9H-プリン、6-アミノ-9-β-D-アラビノフラノシル-9H-プリン、6-アミノ-9-(β-D-アラビノフラノシル)-9H-プリン、9-(β-D-アラビノフラノシル)-9H-プリン-6-アミン、9-(β-D-アラビノフラノシル)-6-アミノ-9H-プリン、9-β-D-アラビノフラノシル-9H-プリン-6-アミン、2'β-ヒドロキシ-2'-デオキシアデノシン |
ビダラビン
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/06/23 02:50 UTC 版)
ビダラビンまたは9-β-D-アラビノフラノシルアデニン (ara-A) とは、単純ヘルペスウイルスおよび水痘・帯状疱疹ウイルスに対して有効な抗ウイルス薬で、経口・静注・局所外用薬として使用される。
- ^ Kijjoa, A.; Sawangwong, P. Drugs and Cosmetics from the Sea. Mar. Drugs. 2004, 2, 73-82.
- ^ a b Sneader, Walter (2005). Drug discovery: a history. New York: Wiley. p. 258. ISBN 0-471-89979-8
- ^ a b Field, H. J.; De Clercq, E. Antiviral Drugs – a short history of their discovery and development. Microbiology Today. 2004, 31, 58-61.
- ^ White, O. D.; Fenner, F. J. Medicinal Virology. 3rd Ed.
- ^ Waterson, A. P. Recent Advances in Clinical Virology (2).
- ^ メルクマニュアル第17版。第154章 p.1127-1128.
- ^ a b c d McGuigan, C. Antiviral Chemotherapy – Cardiff University, 3rd Year Pharmacy Notes Lecture Notes.
- ^ Whitley, R. J.; Tucker, B. C.; Kinkel, A. W.; Barton, N. H.; Pass, R. F.; Whelchel, J. D.; Cobbs, C. G.; Diethelm, A. G.; Buchanan, R. A. Pharmacology, Tolerance, and Antiviral Activity of Vidarabine Monophosphate In Humans.
- ^ a b c Burgers Medicinal Chemistry and Drug Discovery. 6th Ed.
- ^ Lee, W. W.; Benitez, A. Goodman, L.; Baker, B. R. Potential Anticancer Agents. XL. Synthesis of the β-Anomer of 9-(D-Arabinofuranosyl)adenine, J. Am. Chem. Soc. 1960, 82, 2648–2649.
- ^ Pizer, L. I.; Cohen, S. S. Abstr. 136th Meeting, Am. Chem. Soc., 1959, p. 9-C.
- ^ Duschinsky, R.; Pleven, E.; Malvica, J. Heidelberger, C. Abstr. 132nd Meeting, Am. Chem. Soc., 1957, p. 19-C.
- ^ Glaudemans, C. P. J.; Fletcher, Jr., H. G. Syntheses with Partially Benzylated Sugars. II. A Simple Pathway to a "Cisnucleoside," 9-β-D-Arabinofuranosyladenine (Spongoadenosine), J. Org. Chem., 1963, 28, 3004–3006; Reist, E. J.; Goodman, L. Synthesis of 9-β-D-Arabinofuranosylguanine, Biochemistry, 1964, 3, 15–18; Ikehara, M.; Ogiso, Y. Studies of Nucleosides and Nucleotides. LIV. Purine Cyclonucleosides - 19. Further Investigation on the Cleavage of the 8,2'-O-Anhydro Linkage. A New Synthesis of 9-β-D-Arabinofuranosyl-adenine, Tetrahedron, 1972, 28, 3695–3704; Ranganathan, R. A Novel Purine Nucleoside Synthesis of 9-β-D-arabinofuranosyl-adenine, Tetrahedron Lett., 1975, 1185 - 1188; Sowa, T.; Tsunoda, K. Novel Synthesis of Anhydronucleosides via 2',3'-O-Sulfinate of Purine Nucleosides as Intermediates, Bull. Chem. Soc. Jpn., 1975, 48, 3243–3245; Chattopadhyaya. J.; Reese, C. B. Reaction of 8,2'-O-Cycloadenosine with Hydrazine and Amines. Convenient Preparation of 9-β-D-Arabinofuranosyladenine, J. Chem. Soc., Chem. Commun., 1977, 414–415; Ishido, Y.; Sakairi, N.; Okazaki, K.; Nakazaki, N. Partial Protection of Carbohydrate Derivatives. Part 4. Regioselective 2'-O-Deacylation of Fully Acylated Purine and Pyrimidine Ribonucleosides with Hydroxyaminium Acetate, J. Chem. Soc., Perk. Trans. 1, 1980, 563–573.
- ^ No inventor data available, Fermentation of 9-(β-D-Arabinofuranosyl)adenine, Brit. (1969) GB 1159290 1969–0723.
- ^ De Rudder, J.; Privat de Garlhe, M. Inhibitory Effect of Some Nucleosides on the Growth of Various Human Viruses in Tissue Culture, Antimicrobial Agents and Chemotherapy, 1965, 5, 578 - 584; Miller, F. A.; Dixon, G. J.; Ehrlich, J.; Sloan, B. J. McLean, Jr., I. W. Antiviral Activity of 9-β-D-Arabinofuranosyladenine. I. Cell Culture Studies, ibid., 1968, 8, 136–147.
- ^ Komura, H.; Yoshino, T.; Ishido, Y. An Easy Method of Preparing Cyclic Carbonates of Polyhydroxy Compounds by Transesterification with Ethylene Carbonate, Bull. Chem. Soc. Jpn., 1973, 46, 550–553.
- ^ Utagawa, T.; Morisawa, H.; Miyoshi, T.; Yoshinaga, F.; Yamazaki, A.; Mitsusgi, K. A Novel and Simple Method for the Preparation of Adenine Arabinoside by Bacterial Transglycosylation Reactions, FEBS Lett., 1980, 109, 261 - 263; Yokozeki, K.; Yamanaka, F.; Utagawa, T.; Takinami, K.; Hirose, Y.,; Tanaka, A.; Sonomoto, K.; Fukui, S. Production of Adenine Arabinoside by Gel-Entrapped Cells of Enterobacter aerogenes in Water-Organic Cosolvent System, Eur. J. Microbiol. Biotechnol. 1982, 14, 225 - 231; Utagawa, T.; Morisawa, H.; Yamanaka, F.; Yamazaki, A.; Mitsugi, K.; Hirose, Y. Enzymatic Synthesis of Nucleoside Antibiotics. Part 1. Microbial Synthesis of Adenine Arabinoside, Agric. Biol. Chem., 1985, 49, 1053–1058,
- ^ Roshevskaia, L. A.; Barai, V. N.; Zinchenko, A. I.; Kvasiuk, E. I.; Mikhailopulo, L. A. Preparative Synthesis of the Antiviral Nucleoside 9-β-D-Arabinofuranosyladenine by Using Bacterial Cells, Antibiot. Med. Biotekhnol., 1986, 31, 174–178.
- ^ Caprioli, G; Colombo, P.; Farina, P.; Petricciani, L A process for the preparation of fludarabine phosphate from 2-fluroroadenine, EP1464708 A1, Oct. 6, 2004.
- ^ Drug Information Online - https://www.drugs.com/MMX/Vidarabine.html
- ^ ビダラビン点滴静注用300mg「F」 添付文書
- ^ 口唇ヘルペス 市販再発治療薬「アラセナS」
- ^ ビダラビン配合のスイッチOTC薬、口唇ヘルペス再発治療薬「アラセナS」を発売 佐藤製薬｜薬事日報ウェブサイト
[続きの解説]
「ビダラビン」の続きの解説一覧
- 1 ビダラビンとは
- 2 ビダラビンの概要
- 3 発見
- 4 作用機序
- 5 選択性
固有名詞の分類
- ビダラビンのページへのリンク
