チロシン N-モノオキシゲナーゼ
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2018/11/25 14:14 UTC 版)
ナビゲーションに移動 検索に移動| チロシン N-モノオキシゲナーゼ | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 識別子 | |||||||||
| EC番号 | 1.14.13.41 | ||||||||
| CAS登録番号 | 159447-19-5 | ||||||||
| データベース | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB構造 | RCSB PDB PDBj PDBe PDBsum | ||||||||
| 遺伝子オントロジー | AmiGO / EGO | ||||||||
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チロシン N-モノオキシゲナーゼ（tyrosine N-monooxygenase）は、シアノアミノ酸代謝酵素の一つで、次の化学反応を触媒する酸化還元酵素である。
- (1a) L-チロシン + O2 + NADPH + H+ N-ヒドロキシ-L-チロシン + NADP+ + H2O
- (1b) N-ヒドロキシ-L-チロシン + O2 + NADPH + H+ N,N-ジヒドロキシ-L-チロシン + NADP+ + H2O
- (1c) N,N-ジヒドロキシ-L-チロシン (Z)-[4-ヒドロキシフェニルアセトアルデヒドオキシム] + CO2 + H2O
組織名はL-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating)で、別名にtyrosine N-hydroxylase、CYP79A1がある。
参考文献
- Halkier, B.A. and Møller, B.L. The biosynthesis of cyanogenic glucosides in higher plants. Identification of three hydroxylation steps in the biosynthesis of dhurrin in Sorghum bicolor (L.) Moench and the involvement of 1-ACI-nitro-2-(p-hydroxyphenyl)ethane as an intermediate. J. Biol. Chem. 265 (1990) 21114-21121. PMID 2250015
- Sibbesen, O., Koch, B., Halkier, B.A. and Møller, B.L. Cytochrome P-450TYR is a multifunctional heme-thiolate enzyme catalyzing the conversion of L-tyrosine to p-hydroxyphenylacetaldehyde oxime in the biosynthesis of the cyanogenic glucoside dhurrin in Sorghum bicolor (L.) Moench. J. Biol. Chem. 270 (1995) 3506-3511. PMID 7876084
- Bak, S., Olsen, C.E., Halkier, B.A. and Møller, B.L. Transgenic tobacco and Arabidopsis plants expressing the two multifunctional sorghum cytochrome P450 enzymes, CYP79A1 and CYP71E1, are cyanogenic and accumulate metabolites derived from intermediates in dhurrin biosynthesis. Plant Physiol. 123 (2000) 1437-1448. PMID 10938360
- Nielsen, J.S. and Møller, B.L. Cloning and expression of cytochrome P450 enzymes catalyzing the conversion of tyrosine to p-hydroxyphenylacetaldoxime in the biosynthesis of cyanogenic glucosides in Triglochin maritima. Plant Physiol. 122 (2000) 1311-1321. PMID 10759528
- Busk, P.K. and Møller, B.L. Dhurrin synthesis in sorghum is regulated at the transcriptional level and induced by nitrogen fertilization in older plants. Plant Physiol. 129 (2002) 1222-1231. PMID 12114576
- Kristensen, C., Morant, M., Olsen, C.E., Ekstrøm, C.T., Galbraith, D.W., Møller, B.L. and Bak, S. Metabolic engineering of dhurrin in transgenic Arabidopsis plants with marginal inadvertent effects on the metabolome and transcriptome. Proc. Natl. Acad. Sci. USA 102 (2005) 1779-1784. PMID 15665094
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