フーリン (タンパク質) フーリン (タンパク質)の概要

FURIN
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	4OMC, 4OMD, 4RYD, 4Z2A
識別子
記号	FURIN, FUR, PACE, PCSK3, SPC1, furin, paired basic amino acid cleaving enzyme
外部ID	OMIM: 136950 MGI: 97513 HomoloGene: 1930 GeneCards: FURIN
遺伝子の位置 (ヒト)
染色体	15番染色体 (ヒト)
終点	90,883,458 bp
遺伝子の位置 (マウス)
染色体	7番染色体 (マウス)
終点	80,055,184 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• nerve growth factor binding; • ペプチド結合; • 金属イオン結合; • protease binding; • ペプチダーゼ活性; • 血漿タンパク結合; • serine-type endopeptidase inhibitor activity; • serine-type peptidase activity; • 加水分解酵素活性; • endopeptidase activity; • serine-type endopeptidase activity;
細胞の構成要素	• integral component of membrane; • ゴルジ体; • 膜; • 細胞膜; • cell surface; • trans-Golgi network; • 小胞体; • Golgi lumen; • 脂質ラフト; • trans-Golgi network transport vesicle; • エキソソーム; • 細胞外空間; • ゴルジ膜; • 細胞外領域; • エンドソーム; • endosome membrane; • integral component of Golgi membrane;
生物学的プロセス	• negative regulation of low-density lipoprotein particle receptor catabolic process; • negative regulation of transforming growth factor beta1 production; • ウイルスのライフサイクル; • 細胞による分泌; • ペプチド生合成プロセス; • protein processing; • positive regulation of membrane protein ectodomain proteolysis; • extracellular matrix disassembly; • extracellular matrix organization; • viral protein processing; • タンパク質分解; • signal peptide processing; • peptide hormone processing; • regulation of signal transduction; • regulation of protein catabolic process; • collagen catabolic process; • negative regulation of nerve growth factor production; • nerve growth factor processing; • nerve growth factor production; • 細胞増殖; • transforming growth factor beta receptor signaling pathway; • regulation of endopeptidase activity; • negative regulation of endopeptidase activity; • cornification; • zymogen activation; • regulation of lipoprotein lipase activity; • dibasic protein processing; • zymogen inhibition; • positive regulation of transforming growth factor beta1 activation;
	出典:Amigo / QuickGO
オルソログ
	5045
	18550
	ENSG00000140564
	ENSMUSG00000030530
	P09958,A0A024RC70
	P23188
	NM_002569; NM_001289823; NM_001289824
	NM_001081454; NM_011046
NP_001276752; NP_001276753; NP_002560; NP_001369548; NP_001369549;
	NP_001369550; NP_001369551; NP_001276752.1; NP_001276753.1; NP_002560.1
	NP_001074923; NP_035176
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

脚注

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140564 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030530 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ Wise RJ, Barr PJ, Wong PA, Kiefer MC, Brake AJ, Kaufman RJ (Jan 1991), “Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site”, Proc Natl Acad Sci U S A 87 (23): 9378–82, doi:10.1073/pnas.87.23.9378, PMC 55168, PMID 2251280
^ Kiefer MC, Tucker JE, Joh R, Landsberg KE, Saltman D, Barr PJ (Jan 1992), “Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15”, DNA Cell Biol 10 (10): 757–69, doi:10.1089/dna.1991.10.757, PMID 1741956
^ ^a ^b Entrez Gene: FURIN furin (paired basic amino acid cleaving enzyme)
^ Roebroek AJ, Schalken JA, Leunissen JA, Onnekink C, Bloemers HP, Van de Ven WJ (September 1986), “Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein”, EMBO J. 5 (9): 2197–202, PMC 1167100, PMID 3023061
^ Lin L, Nemeth E, Goodnough JB, Thapa DR, Gabayan V, Ganz T (2008), “Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site”, Blood Cells Mol. Dis. 40 (1): 122–31, doi:10.1016/j.bcmd.2007.06.023, PMC 2211380, PMID 17869549
^ Kuninger D, Kuns-Hashimoto R, Nili M, Rotwein P (2008), “Pro-protein convertases control the maturation and processing of the iron-regulatory protein, RGMc/hemojuvelin”, BMC Biochem. 9: 9, doi:10.1186/1471-2091-9-9, PMC 2323002, PMID 18384687
^ Thomas G (October 2002), “Furin at the cutting edge: from protein traffic to embryogenesis and disease”, Nat. Rev. Mol. Cell Biol. 3 (10): 753–66, doi:10.1038/nrm934, PMC 1964754, PMID 12360192
^ Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R, Fugere M, Day R, Sabet M, Pellecchia M, Liddington RC, Smith JW, Mustelin T, Guiney DG, Lebl M, Strongin AY (July 2007), “Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens”, J. Biol. Chem. 282 (29): 20847–53, doi:10.1074/jbc.M703847200, PMID 17537721
^ Pesu M, Watford WT, Wei L, Xu L, Fuss I, Strober W, Andersson J, Shevach EM, Quezado M, Bouladoux N, Roebroek A, Belkaid Y, Creemers J, O'Shea JJ (August 2008), “T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance”, Nature 455 (7210): 246, doi:10.1038/nature07210, PMC 2758057, PMID 18701887
^ “新型コロナウイルスの感染を増強する抗体を発見 -COVID-19の重症化に関与する可能性-”. 大阪大学微生物病研究所 (2021年5月21日). 2021年8月16日閲覧。
^ “新型コロナウイルス抗原について”. 京都大学ウイルス・再生医科学研究所 (2020年11月5日). 2021年8月16日閲覧。
^ 竹田　誠 (国立感染症研究所) (2021年8月16日). “新型コロナウイルスSARS-CoV-2の宿主プロテアーゼによる開裂活性化”. 日本病態プロテアーゼ学会. 2021年8月16日閲覧。
^ Markus Hoffmann,Hannah Kleine-Weber and Stefan Pohlmann (2020-05-21). “A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells”. Molecular Cell,78 (Elsevier Inc.). doi:10.1016/j.molcel.2020.04.022 2021年8月16日閲覧。.
^ Menachery et al. (2021年1月25日). “Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis”. Nature Research. 2021年8月20日閲覧。
^ McCaul et al. (2021年8月1日). “THE ORIGIN OF COVID-19: An Investigation of the Wuhan Institute of Virology”. United States House Foreign Affairs Committee Minority Staff. 2021年8月2日閲覧。
^ Wan, L; Molloy S S, Thomas L, Liu G, Xiang Y, Rybak S L, Thomas G (Jul. 1998), “PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization”, Cell (UNITED STATES) 94 (2): 205–16, doi:10.1016/S0092-8674(00)81420-8, ISSN 0092-8674, PMID 9695949

[前の解説]

[続きの解説]

「フーリン (タンパク質)」の続きの解説一覧

1 フーリン (タンパク質)とは
2 フーリン (タンパク質)の概要
3 機能
4 相互作用

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140564 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030530 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[pmid2251280-5] Wise RJ, Barr PJ, Wong PA, Kiefer MC, Brake AJ, Kaufman RJ (Jan 1991), “Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site”, Proc Natl Acad Sci U S A 87 (23): 9378–82, doi:10.1073/pnas.87.23.9378, PMC 55168, PMID 2251280

[pmid1741956-6] Kiefer MC, Tucker JE, Joh R, Landsberg KE, Saltman D, Barr PJ (Jan 1992), “Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15”, DNA Cell Biol 10 (10): 757–69, doi:10.1089/dna.1991.10.757, PMID 1741956

[entrez_5045-7] Entrez Gene: FURIN furin (paired basic amino acid cleaving enzyme)

[pmid3023061-8] Roebroek AJ, Schalken JA, Leunissen JA, Onnekink C, Bloemers HP, Van de Ven WJ (September 1986), “Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein”, EMBO J. 5 (9): 2197–202, PMC 1167100, PMID 3023061

[pmid17869549-9] Lin L, Nemeth E, Goodnough JB, Thapa DR, Gabayan V, Ganz T (2008), “Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site”, Blood Cells Mol. Dis. 40 (1): 122–31, doi:10.1016/j.bcmd.2007.06.023, PMC 2211380, PMID 17869549

[pmid18384687-10] Kuninger D, Kuns-Hashimoto R, Nili M, Rotwein P (2008), “Pro-protein convertases control the maturation and processing of the iron-regulatory protein, RGMc/hemojuvelin”, BMC Biochem. 9: 9, doi:10.1186/1471-2091-9-9, PMC 2323002, PMID 18384687

[pmid12360192-11] Thomas G (October 2002), “Furin at the cutting edge: from protein traffic to embryogenesis and disease”, Nat. Rev. Mol. Cell Biol. 3 (10): 753–66, doi:10.1038/nrm934, PMC 1964754, PMID 12360192

[pmid17537721-12] Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R, Fugere M, Day R, Sabet M, Pellecchia M, Liddington RC, Smith JW, Mustelin T, Guiney DG, Lebl M, Strongin AY (July 2007), “Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens”, J. Biol. Chem. 282 (29): 20847–53, doi:10.1074/jbc.M703847200, PMID 17537721

[pmid18701887-13] Pesu M, Watford WT, Wei L, Xu L, Fuss I, Strober W, Andersson J, Shevach EM, Quezado M, Bouladoux N, Roebroek A, Belkaid Y, Creemers J, O'Shea JJ (August 2008), “T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance”, Nature 455 (7210): 246, doi:10.1038/nature07210, PMC 2758057, PMID 18701887

[Osaka-u-2021-05-21-14] “新型コロナウイルスの感染を増強する抗体を発見 -COVID-19の重症化に関与する可能性-”. 大阪大学微生物病研究所 (2021年5月21日). 2021年8月16日閲覧。

[Kyoto-u-2020-11-05-15] “新型コロナウイルス抗原について”. 京都大学ウイルス・再生医科学研究所 (2020年11月5日). 2021年8月16日閲覧。

[JSPP-2021-16] 竹田　誠 (国立感染症研究所) (2021年8月16日). “新型コロナウイルスSARS-CoV-2の宿主プロテアーゼによる開裂活性化”. 日本病態プロテアーゼ学会. 2021年8月16日閲覧。

[MolecularCell-2020-05-21-17] Markus Hoffmann,Hannah Kleine-Weber and Stefan Pohlmann (2020-05-21). “A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells”. Molecular Cell,78 (Elsevier Inc.). doi:10.1016/j.molcel.2020.04.022 2021年8月16日閲覧。.

[Nature-2021-01-25-18] Menachery et al. (2021年1月25日). “Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis”. Nature Research. 2021年8月20日閲覧。

[House-2021-08-01-19] McCaul et al. (2021年8月1日). “THE ORIGIN OF COVID-19: An Investigation of the Wuhan Institute of Virology”. United States House Foreign Affairs Committee Minority Staff. 2021年8月2日閲覧。

[pmid9695949-20] Wan, L; Molloy S S, Thomas L, Liu G, Xiang Y, Rybak S L, Thomas G (Jul. 1998), “PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization”, Cell (UNITED STATES) 94 (2): 205–16, doi:10.1016/S0092-8674(00)81420-8, ISSN 0092-8674, PMID 9695949

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フーリン (タンパク質) フーリン (タンパク質)の概要

フーリン (タンパク質)

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