フーリン (タンパク質)
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2024/03/21 15:16 UTC 版)
相互作用
フーリンはPACS1とタンパク質間相互作用を示す[20]。
参考文献
- Nakayama K (1998), “Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins.”, Biochem. J. 327 ( Pt 3): 625–35, PMC 1218878, PMID 9599222
- Bassi DE, Mahloogi H, Klein-Szanto AJ (2000), “The proprotein convertases furin and PACE4 play a significant role in tumor progression.”, Mol. Carcinog. 28 (2): 63–9, doi:10.1002/1098-2744(200006)28:2<63::AID-MC1>3.0.CO;2-C, PMID 10900462
- Hallenberger S, Bosch V, Angliker H, et al. (1992), “Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160.”, Nature 360 (6402): 358–61, doi:10.1038/360358a0, PMID 1360148
- Rehemtulla A, Kaufman RJ (1992), “Preferred sequence requirements for cleavage of pro-von Willebrand factor by propeptide-processing enzymes.”, Blood 79 (9): 2349–55, PMID 1571548
- Leduc R, Molloy SS, Thorne BA, Thomas G (1992), “Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage.”, J. Biol. Chem. 267 (20): 14304–8, PMID 1629222
- Barr PJ, Mason OB, Landsberg KE, et al. (1991), “cDNA and gene structure for a human subtilisin-like protease with cleavage specificity for paired basic amino acid residues.”, DNA Cell Biol. 10 (5): 319–28, doi:10.1089/dna.1991.10.319, PMID 1713771
- Herz J, Kowal RC, Goldstein JL, Brown MS (1990), “Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment.”, EMBO J. 9 (6): 1769–76, PMC 551881, PMID 2112085
- van den Ouweland AM, van Duijnhoven HL, Keizer GD, et al. (1990), “Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2.”, Nucleic Acids Res. 18 (3): 664, doi:10.1093/nar/18.3.664, PMC 333486, PMID 2408021
- Van den Ouweland AM, Van Groningen JJ, Roebroek AJ, et al. (1989), “Nucleotide sequence analysis of the human fur gene.”, Nucleic Acids Res. 17 (17): 7101–2, doi:10.1093/nar/17.17.7101, PMC 318436, PMID 2674906
- Roebroek AJ, Schalken JA, Leunissen JA, et al. (1986), “Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein.”, EMBO J. 5 (9): 2197–202, PMC 1167100, PMID 3023061
- Molloy SS, Thomas L, VanSlyke JK, et al. (1994), “Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface.”, EMBO J. 13 (1): 18–33, PMC 394775, PMID 7508380
- Brakch N, Dettin M, Scarinci C, et al. (1995), “Structural investigation and kinetic characterization of potential cleavage sites of HIV GP160 by human furin and PC1.”, Biochem. Biophys. Res. Commun. 213 (1): 356–61, doi:10.1006/bbrc.1995.2137, PMID 7639757
- Takahashi S, Kasai K, Hatsuzawa K, et al. (1993), “A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells.”, Biochem. Biophys. Res. Commun. 195 (2): 1019–26, doi:10.1006/bbrc.1993.2146, PMID 7690548
- Hendy GN, Bennett HP, Gibbs BF, et al. (1995), “Proparathyroid hormone is preferentially cleaved to parathyroid hormone by the prohormone convertase furin. A mass spectrometric study.”, J. Biol. Chem. 270 (16): 9517–25, doi:10.1074/jbc.270.16.9517, PMID 7721880
- Dubois CM, Laprise MH, Blanchette F, et al. (1995), “Processing of transforming growth factor beta 1 precursor by human furin convertase.”, J. Biol. Chem. 270 (18): 10618–24, doi:10.1074/jbc.270.18.10618, PMID 7737999
- Gu M, Rappaport J, Leppla SH (1995), “Furin is important but not essential for the proteolytic maturation of gp160 of HIV-1.”, FEBS Lett. 365 (1): 95–7, doi:10.1016/0014-5793(95)00447-H, PMID 7774724
- Schäfer W, Stroh A, Berghöfer S, et al. (1995), “Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin.”, EMBO J. 14 (11): 2424–35, PMC 398356, PMID 7781597
- Mbikay M, Seidah NG, Chrétien M, Simpson EM (1995), “Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human.”, Genomics 26 (1): 123–9, doi:10.1016/0888-7543(95)80090-9, PMID 7782070
- ^ a b c GRCh38: Ensembl release 89: ENSG00000140564 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030530 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ Wise RJ, Barr PJ, Wong PA, Kiefer MC, Brake AJ, Kaufman RJ (Jan 1991), “Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site”, Proc Natl Acad Sci U S A 87 (23): 9378–82, doi:10.1073/pnas.87.23.9378, PMC 55168, PMID 2251280
- ^ Kiefer MC, Tucker JE, Joh R, Landsberg KE, Saltman D, Barr PJ (Jan 1992), “Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15”, DNA Cell Biol 10 (10): 757–69, doi:10.1089/dna.1991.10.757, PMID 1741956
- ^ a b Entrez Gene: FURIN furin (paired basic amino acid cleaving enzyme)
- ^ Roebroek AJ, Schalken JA, Leunissen JA, Onnekink C, Bloemers HP, Van de Ven WJ (September 1986), “Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein”, EMBO J. 5 (9): 2197–202, PMC 1167100, PMID 3023061
- ^ Lin L, Nemeth E, Goodnough JB, Thapa DR, Gabayan V, Ganz T (2008), “Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site”, Blood Cells Mol. Dis. 40 (1): 122–31, doi:10.1016/j.bcmd.2007.06.023, PMC 2211380, PMID 17869549
- ^ Kuninger D, Kuns-Hashimoto R, Nili M, Rotwein P (2008), “Pro-protein convertases control the maturation and processing of the iron-regulatory protein, RGMc/hemojuvelin”, BMC Biochem. 9: 9, doi:10.1186/1471-2091-9-9, PMC 2323002, PMID 18384687
- ^ Thomas G (October 2002), “Furin at the cutting edge: from protein traffic to embryogenesis and disease”, Nat. Rev. Mol. Cell Biol. 3 (10): 753–66, doi:10.1038/nrm934, PMC 1964754, PMID 12360192
- ^ Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R, Fugere M, Day R, Sabet M, Pellecchia M, Liddington RC, Smith JW, Mustelin T, Guiney DG, Lebl M, Strongin AY (July 2007), “Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens”, J. Biol. Chem. 282 (29): 20847–53, doi:10.1074/jbc.M703847200, PMID 17537721
- ^ Pesu M, Watford WT, Wei L, Xu L, Fuss I, Strober W, Andersson J, Shevach EM, Quezado M, Bouladoux N, Roebroek A, Belkaid Y, Creemers J, O'Shea JJ (August 2008), “T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance”, Nature 455 (7210): 246, doi:10.1038/nature07210, PMC 2758057, PMID 18701887
- ^ “新型コロナウイルスの感染を増強する抗体を発見 -COVID-19の重症化に関与する可能性-”. 大阪大学微生物病研究所 (2021年5月21日). 2021年8月16日閲覧。
- ^ “新型コロナウイルス抗原について”. 京都大学 ウイルス・再生医科学研究所 (2020年11月5日). 2021年8月16日閲覧。
- ^ 竹田 誠 (国立感染症研究所) (2021年8月16日). “新型コロナウイルスSARS-CoV-2の宿主プロテアーゼによる開裂活性化”. 日本病態プロテアーゼ学会. 2021年8月16日閲覧。
- ^ Markus Hoffmann,Hannah Kleine-Weber and Stefan Pohlmann (2020-05-21). “A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells”. Molecular Cell,78 (Elsevier Inc.). doi:10.1016/j.molcel.2020.04.022 2021年8月16日閲覧。.
- ^ Menachery et al. (2021年1月25日). “Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis”. Nature Research. 2021年8月20日閲覧。
- ^ McCaul et al. (2021年8月1日). “THE ORIGIN OF COVID-19: An Investigation of the Wuhan Institute of Virology”. United States House Foreign Affairs Committee Minority Staff. 2021年8月2日閲覧。
- ^ Wan, L; Molloy S S, Thomas L, Liu G, Xiang Y, Rybak S L, Thomas G (Jul. 1998), “PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization”, Cell (UNITED STATES) 94 (2): 205–16, doi:10.1016/S0092-8674(00)81420-8, ISSN 0092-8674, PMID 9695949
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